Abstract
Originating in the work of DeDuve’s group (1), the concept of drug targeting is intended to improve the selectivity of transfer of a drug to target cells (2). The drug targeting consists of the association of a therapeutic effect and of a tissular specificity resting on the molecular association of a drug and a vector in a complex. The drug distribution in the body, being in principle governed by the vector, can be modified as a function of the chosen vector.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
DeDuve C., Debarsy T., Poole B., Trouet A., Tulkens P., Van Hoof F., Biochem. Pharmacol., 23: 2495–531 (1974)
Trouet A., Eur. J. Cancer, 14: 105–11 (1978)
Alving C.R., Steck E.A., Trends Biochem. Sci. 4: N175–7 (1979)
Mathe G., Tran B.L., Bernard J., C.R. Acad. Sci. 246: 1626 (1958)
Blythman H.E., Casellas P., Gros O., Gros P., Jansen F.K., Paolucci F., Pau B., Vidal H., Nature 290: 145–6 (1981)
Olsnes S., Pihl A., Pharmacol. Ther. 15: 355–81 (1981)
Holcenberg J.S., Ann. Rev. Biochem. 51: 795–812 (1982)
Desnick R.J., Thorpe S.R., Fiddler M.B., Physiol. Rev. 56: 57–99 (1976)
Cawley D.B., Herschman H.R., Gilliland D.G., Collier R.J., Cell, 22: 563–70 (1980)
Harper C.G., Gonatas J.O., Stieber A., Gonatas N.K., Brain Res., 188: 465–72 (1980)
Fiume L., Busi C., Mattioli A., Balboni P.G., Barbanti-Brodano G., FEBS Lett., 129: 261–4 (1981)
Uchida T., Miyake Y., Yamaizumi M., Mekada E., Okada Y., Biophys. Biochem. Res. Comm. 87: 371–9 (1979)
Bizzini B., Grob P., Glicksman M.A., Akert K., Brain Res., 193: 221–7 (1980)
Remy M.H., Poznansky M.J., Lancet 8 Juillet: 68–70 (1978)
Marshall J.J., Trends Biochem. Sei. 3: 79–83 (1978)
Neufeld E.F., Ashwell G. in “Biochemistry of Glycoproteins & Proteoglycans” pp. 241–66 (ed. Lennarz) Plenum Press London (1980)
Weiinder K.G., Eur. J. Biochem. 96: 483–502 (1979)
Avrameas S., Ternynck T., Immunochem. 8: 1175–9 (1971)
Wilson M.B., Nakane P.K. in “Immunofluorescence and related staining techniques” pp. 215–24 (eds.Knapp, Holubar and Wick) Elsevier, Amsterdam (1978)
Schwartz B.A., Gray G.R., Arch. Biochem. Biophys. 181: 542–9 (1977)
Uliberg S., Acta Radiol. Suppl. 118: 1–110 (1954)
Graham R.C. Jr., Karnovsky M.J., J. Histochem. Cytochem. 14:291–302 (1966)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Plenum Press, New York
About this chapter
Cite this chapter
Marincol, P., Remy, MH., Domurado, D. (1983). Preparation of Enzyme Polymers for Therapeutical Use: Preliminary “In Vivo” Study. In: Chiellini, E., Giusti, P. (eds) Polymers in Medicine. Polymer Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7643-3_8
Download citation
DOI: https://doi.org/10.1007/978-1-4615-7643-3_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-7645-7
Online ISBN: 978-1-4615-7643-3
eBook Packages: Springer Book Archive