Abstract
Sterols are important structural components of cell and organelle membranes of higher organisms. The primary sterol found in animal organisms is cholesterol. Analogs of cholesterol in the plant kingdom are, as a class, termed phytosterols. Plant sterols resemble cholesterol structurally in that they all have a steroid nucleus, a 3β hydroxyl group, and a double bond between carbon atoms 5 and 6. The major differences are in side chain substitution and/or unsaturation. Bean1 has described 44 sterols that are present in plants. The principal plant sterols are β sitosterol (24α ethylcholesterol) which comprises 45–95% of the total sterol present in plant oils; campesterol (24α methylcholesterol) which may total 30% of the total sterols of seed oils; and stigmasterol (∆22, 24α ethylcholesterol) which may account for as much as 25% of the total sterol of seed oils. Brassicasterol (∆7,22, 24α methylcholesterol) is also present in appreciable quantities in plant oils and a sterol found principally in yeast, ergosterol (∆22, 24α methylcholesterol) is present in significant amounts in corn, cottonseed, peanut, and linseed oils. Weihrauch and Gardner2 have summarized the sterol content of a number of foods of plant origin. Tables 1 and 2 present data on the phytosterol content of selected vegetable oils and foods.
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References
Bean, G. A. (1973). Phytosterols. Adv. Lipid Res. 11: 193–218.
Weihrauch, J. L., and Gardner, J. M. (1978). Sterol content of foods of plant origin. J. Am. Dietetic Assoc. 73: 39–47.
Shipley, R. E., Pfieffer, R. R., Marsh, M. M., and Anderson, R. C. (1958). Sitosterol feeding. Chronic animal and clinical toxicology and tissue analysis. Circ. Res. 6: 373–382.
Malini, T., and Vanithakumari, G. (1990). Rat toxicity studies with β-sitosterol. J. Ethnopharmacol. 28: 221–234.
Ellis, G. W., and Gardner, J. A. (1912). The origin and destiny of cholesterol in the organism. VIII. On the cholesterol content of the liver of rabbits under various diets and during evaluation. Proc. Roy. Soc. London B84: 461–470.
Schoenheimer, R. (1924). Uber die sterine des kaninchenkotes. Hoppe Seyler’s Z. Physiol. Chem. 180: 32–37.
Schoenheimer, R. (1929). Versuch einer bilanz am kaninchen bei verfütterung mit sitosterin. Hoppe Seyler’s Z. Physiol. Chem. 180: 24–32.
Schoenheimer, R., von Behring, H., and Hammel, R. (1930). Über die spezifität der resorption von sterinen, abhängig von ihrer konstitution. Hoppe Seyler’s Z. Physiol. Chem. 192: 117–124.
Schoenheimer, R., and von Behring, H. (1930). Ist unbestrahltes ergosterin resorbierbar. Klin. Wochenschr. 9: 1308.
Schoenheimer, R. (1931). New contributions in sterol metabolism. Science 74: 579–584.
Gould, G. R.. and Cook, R. P. (1958). The metabolism of cholesterol and other sterols in the animal organisms. In: Cook, R. P. (ed.), Cholesterol, Chemistry, Biochemistry, and Pathology. New York, Academic Press, pp. 237–307.
Kritchevsky, D., and Defendi, V. (1962). Deposition of tritium-labeled sterols (cholesterol, sitosterol, lanosterol) in brain and other organs of the growing chicken. J. Neurochem. 9: 421–425.
Gould, R. G. (1955). Absorbability of β-sitosterol. Trans. NY Acad. Sci. 18: 129–134.
Sylven, C., and Borgstrom, B. (1964). Absorption and lymphatic transport of cholesterol and sitosterol in the rat. J. Lipid Res. 10: 179–182.
Swell, L., Trout, E. C., Jr., Field, H., Jr., and Treadwell, C. R. (1959). Absorption of H-3-β-sitosterol in the lymph fistula rat. Proc. Exp. Biol. Med. 100: 140–142.
Hernandez, H. H., Peterson, D. W., Chaikoff, I. L., and Dauben, W. G. (1953). Absorption of cholesterol-4C14 in rats fed mixed soybean sterols and b sitosterol. Proc. Soc. Exp. Biol. Med. 83: 498–499.
Vahouny, G. V., Connor, W. E., Subramaniam, S., Lin, D. S., and Gallo, L. L. (1983). Comparative lymphatic absorption of sitosterol, stigmasterol, and fucosterol and differential inhibition of cholesterol absorption. Am. J. Clin. Nutr. 37: 805–809.
Ivy, A. C., Lin, T. M., and Karvinen, E. (1955). Absorption of dehydrocholesterol and soya sterol by the rat’s intentine. Am. J. Physiol. 183: 79–85.
Harahan, D. J., and Wakil, S. J. (1953). Studies on absorption and metabolism of ergosterol-C14. Arch. Biochem. Biophys. 44: 150–158.
Subbiah, M. T. R., Kottke, B. A., and Carlo, I. A. (1971). Uptake of campesterol in pigeon intestine. Biochim. Biophys. Acta 249: 643–6646.
Heinemann, T., Axtmann, G., and von Bergmann, K. (1993). Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest. 23: 827–831.
Pollak, O. J., and Kritchevsky, D. (1981). Sitosterol. Basel, S. Karger.
Salen, G., Ahrens, E. H., Jr., and Grundy, S. M. (1970). Metabolism of β sitosterol in man. J. Clin. invest. 49: 952–967.
Kritchevsky, D., Davidson, L. M., Mosbach, E. H., and Cohen, B. I. (1981). Identification of acidic steroids in feces of monkeys fed β sitosterol. Lipids 16: 77–78.
Kritchevsky, D., Staple, E.. and Whitehouse, M. W. (1961). Oxidation of ergosterol by rat and mouse liver mitochondria. Proc. Soc. Exp. Biol. Med. 106: 704–708.
Peterson, D. W. (1951). Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc. Soc. Exp. Biol. Med. 78: 143–147.
Peterson, D. W., Shneour, E. A., Peek, N. F., and Gaffey, H. W. (1953). Dietary constituents affecting plasma and liver cholesterol in cholesterol-fed chicks. J. Nutr. 50: 191–201.
Peterson, D. W., Shneour, E. A., and Peek, N. F. (1954). Effects of dietary sterols and sterol esters on plasma and liver cholesterol in the chick. J. Nutr. 53: 451–459.
Mattson, F. H., Volpenhein, R. A., and Erickson, B. A. (1977). Effect of plant sterol esters on the absorption of dietary cholesterol. J. Nutr. 107: 1139–1146.
Peterson, D. W., Nichols, C. W., Jr., and Shneour, E. A. (1952). Some relationships among dietary sterols, plasma, and liver cholesterol levels and atherosclerosis in chicks. J. Nutr. 47: 57–65.
Pollak, O. J. (1953). Successful prevention of experimental hypercholesterolemia and cholesterol atherosclerosis in the rabbit. Circulation 7: 696–701.
Pollak, O. J. (1953). Reduction of blood cholesterol in man. Circulation 7: 702–706.
Best, M. M., Duncan, C. H., VanLoon, E. J., and Wathen, J. D. (1954). Lowering of serum cholesterol by administration of a plant sterol. Circulation 10: 201–206.
Farquhar, J. W., Smith, R. E., and Dempsey, M. S. (1956). The effect of beta sitosterol on the serum lipids of young men with arteriosclerotic heart disease. Circulation 14: 77–82.
Lees, A. M., Mok, H. Y. I., Lees, R. S., McCluskey, M. A., and Grundy, S. M. (1977). Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 28: 325–338.
Pelletier, X., Belbraouet, S., Mirabel, D., Mordret, F., Perrin, J. L., Pages, Y., and Debry, G. (1995). A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann. Nutr. Metab. 39: 291–295.
Sugano, M., Morioka, H., and Ikeda, H. (1977). A comparison of hypocholesterolemic activity of β sitosterol and β sitostanol in rats. J. Nutr. 107: 2011–2019.
Heinemann, T., Leiss, O., and von Bergmann, K. (1986). Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia. Atherosclerosis 61: 219–223.
Becker, M., Staab, D., and von Bergmann, K. (1993). Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J. Pediatr. 122: 293–296.
Denke, M. (1995). Lack of effect of low dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia. Am. J. Clin. Nutr. 61: 392–396.
Gylling, H., and Miettinen, T. A. (1994). Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment. Diabelologia 37: 773–780.
Vanhanen, H. T., Kajander, J., Lehtovirta, H., and Miettinen, T. A. (1994). Serum levels, absorption efficiency, faecal elimination, and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. Clin. Sci. 87: 61–67.
Miettinen, T. A., Puska, P., Gylling, H., Vanhanen, H., and Vartiainen, E. (1995). Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N. Engl. J. Med. 333: 1308–1312.
Levere, A. H., Bozian, R. C., Craft, G., Jackson, R. S., and Wilkinson, C. F., Jr. (1958). The “sitosterols”: variability of serum cholesterol levels and difficulty of evaluating decholesterolizing agents. Metabolism 7: 338–348.
Groover, M. E., Jr., Jernigan, J. A., and Martin, C. D. (1960). Variations in serum lipid concentration and clinical coronary disease. Am. J. Med. Sci. 239: 133–139.
Kritchevsky, D. (1985). Variation in serum cholesterol levels. In: Weininger, J., Briggs, G. M. (eds.), Nutrition Update. New York, Wiley 2: 91–103.
Gordon, D. J., Hyde, J., Trost, D. C., Whaley, F. S., Hannan, P. J., Jacobs, D. R., and Ekelund, L. G. (1988). Cyclic seasonal variation in plasma lipid and lipoprotein levels: the lipid research clinics coronary primary prevention trial placebo group. J. Clin. Epidemol. 41: 679–689.
Durrington, P. N. (1990). Biological variation in serum lipid concentrations. Scand. J. Clin. Lab. Invest. 50: Suppl. 198: 86–91.
Kritchevsky, D. (1992). Variation in plasma cholesterol levels. Nutr. Today Sept./Oct. 21–23.
Wilkinson, C. F., Jr., Boyle, E., Jackson, R. S., sod Benjamin, M. R. (1955). Effect of varying the intake of dietary fat and the ingestion of sitosterol on lipid and lipoprotein fractions of human serum. Metabolism 4: 302–309.
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Kritchevsky, D. (1997). Phytosterols. In: Kritchevsky, D., Bonfield, C. (eds) Dietary Fiber in Health and Disease. Advances in Experimental Medicine and Biology, vol 427. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5967-2_24
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