Abstract
Oxazaphosphorines (e.g., 4-hydroperoxycyclophosphamide (4-HC), mafosfamide, ifosfamide) are commonly used to purge malignant blood cells from autologous bone marrow samples before reinfusion (Beran et al., 1987; Yeager et al., 1990; Carlo-Stella et al., 1994). Recently published studies from many laboratories including our own have unequivocally established that there is an associative as well as causative inverse relationship between cellular content of ALDH — whether of normal or malignant cell origin — and sensitivity to oxazaphosphorines (Kohn et al., 1987; Russo and Hilton, 1988; von Eitzen et al., 1994; Agarwal et al., 1995; Sreerama and Sladek, 1995; Sladek et al., 1995; Moreb et al., 1995). Until now, only class 1 (ALDH1 and ALDH2) and class 3 (ALDH3) isozymes (constitutive and inducible forms) have been implicated in the detoxification of cyclophosphamide derivatives such as 4-HC and mafosfamide (Dockham et al., 1992; Bunting and Townsend, 1996).
A part of this study will be included in the M.D. thesis of C. Dereskewitz, Medical Faculty, University of Hamburg.
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Meier-Tackmann, D., Agarwal, D.P., Krueger, W., Dereskewitz, C., Tawhid Hassan, H., Zander, A.R. (1996). Changes in Aldehyde Dehydrogenase Isozymes Expression in Long-Term Cultures of Human Hematopoietic Progenitor Cells. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_7
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DOI: https://doi.org/10.1007/978-1-4615-5871-2_7
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