Abstract
Aldose reductase has been implicated in a number of diabetic complications including background retinopathy (microaneurysms) and cataracts. The formation of microaneurysms is independently related to duration of disease and hyperglycemia, and is found in post-pubertal patients (Murphy et al., 1990). They are thought to be caused by the loss of pericytes resulting from the activity of aldose reductase. The mechanisms regulating the expression of the enzyme in specific tissues and in pathological conditions are unknown.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Bohren, K.M., Bullock, B., Wermuth, B. and Gabbay K.H. (1989), The aldo-keto reductase superfamily: cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases, J. Biol. Chem. 264, 9547–9551.
Fabre, S., Manin, M., Pailhoux, E., Veyssiere, G. and Jean, C. (1994), Identification of a functional androgen response element in the promoter of the gene for the androgen-regulated aldose reductase-like protein specific to the mouse vas deferens, J. Biol. Chem. 269, 5857–5864.
Gorman, C.M., Moffat, L.F., and Howard, B.H. (1982), Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells, Mol. Cell. Biol. 2, 1044–1051.
Graham, A., Brown, L., Hedge, P.J., Gammack, A.J. and Markham, A.F. (1991), Structure of the human aldose reductase gene, J. Biol. Chem. 266, 6872–6877.
Lau, E. T., Cao, D., Lin, C., Chung, S. K. and Chung, S. S. (1995), Tissue-specific expression of two aldose reductase-like genes in mice: abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland, Biochem. J. 312, 609–615.
Martinez, A., Pailhoux, E., Berger, M. and Jean, C. (1990), Androgen regulation of the mRNA encoding a major protein of the mouse vas deferens, Mol. Cell. Endocrinol. 72, 201–211.
Murphy, R. P., Nanda, M., Plotnick, L., Enger, C., Vitale, S. and Pratz, A. (1990), The relationship of puberty to diabetic retinopathy, Arch. Ophthalmol. 108, 215–218.
Pailhoux, E.A., Martinez, A., Veyssiere, G.M. and Jean, C.G. (1990), Androgen-dependent protein from mouse vas deferens, J. Biol. Chem. 265, 19932–19936.
Pailhoux, E., Veyssiere, G., Fabre, S., Tournaire, C. and Jean, C. (1992), the genomic organization and DNA sequence of the mouse vas deferens androgen-regulated protein gene. J. Steroid. Biochem. Molec. Biol. 42, 561–568.
Wang, K., Bohren, K.M. and Gabbay K.H. (1993), Characterization of the human aldose reductase gene promoter, J. Biol. Chem. 268, 16052–16058.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ruepp, B.U., Bohren, K.M., Gabbay, K.H. (1996). Characterization of an Element Resembling an Androgen Response Element (are) in the Human Aldose Reductase Promoter. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_58
Download citation
DOI: https://doi.org/10.1007/978-1-4615-5871-2_58
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7692-7
Online ISBN: 978-1-4615-5871-2
eBook Packages: Springer Book Archive