Abstract
Vitamin A is vital for promotion of general growth, differentiation of epithelial tissues, visual function and reproduction. A connection between vitamin A and cancer was made 70 years ago when it was found that carcinomas of the stomach appeared in albino rats fed a vitamin A deficient diet (Fujimaki, 1926). The history of the carotenoids predates that of vitamin A. However, it was during the subsequent four years that the high vitamin A activity of carotene was demonstrated and its metabolism to vitamin A in the liver documented (for a review see Pawson, 1981). In 1930, Karrer presented a structural assignment for β-carotene and a year later, he proposed a structural formula for vitamin A alcohol (Karrer, 1938; Pawson, 1981).
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Pocker, Y., Li, H. (1996). Mechanistic Enzymology of Liver Alcohol Dehydrogenase. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_38
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