Abstract
The peroxidative degradation of membrane lipids is initiated by free radicals originating from oxygen or in certain cases, the metabolism of xenobiotics. It is generally agreed that the peroxidation of polyunsaturated membrane lipids is a well-controlled, ongoing event associated with normal cell turnover and the overall process of aging. Conversely, the process of uncontrolled lipid peroxidation is a biochemical event associated with hepatic injury as a result of exposure to halogenated hydrocarbons, excessive alcohol ingestion, and acute or chronic iron overload (Comporti, 1985). Consistent with the auto-catalytic nature of lipid peroxoidation, each of these chemical agents can result in the production of a radical species capable of initiating lipid peroxidation.
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Hartley, D.P., Petersen, D.R. (1996). Profiles of Hepatic Cellular Protein Adduction by Malondialdehyde and 4-Hydroxynonenal. In: Weiner, H., Lindahl, R., Crabb, D.W., Flynn, T.G. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 6. Advances in Experimental Medicine and Biology, vol 414. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5871-2_15
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DOI: https://doi.org/10.1007/978-1-4615-5871-2_15
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