Abstract
Concern about late effects of chemotherapy is a novel problem for the oncologist. As late as the 1960s, survival from childhood cancer was less than 20% overall, with many subsets of patients demonstrating even worse outcome [1]. However, in the last three decades, treatment for malignancy in children has become far more effective. By the late 1980s, 60% to 70% of children with cancer (figure 1) were surviving their illness [2]. Although outcomes were less favorable for certain types of malignancy (figure 2), it is estimated that by the year 2000, one in 900 young adults will be a survivor of childhood cancer [3]. This has created a new area of concern for pediatricians, oncologists, and internists. Dealing with the late effects of therapy, an unheard- of luxury in the 1960s, has now become a dilemma for patients, practitioners, and families of patients and must take a prominent position in the practice of pediatric oncology.
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Boring CO, Squires TS, Tong T, Montgomery S. 1994. Cancer statistics, 1994. Cancer 44:7–26.
Li FP, Fine W, Jaffe N, Holmes GE, Holmes FF. 1979. Offspring of patients treated for cancer in childhood. J Natl Cancer Inst 62:1193–1197.
Meadows AT, Baum E, Fossati-Beltani F, et al 1985. Second malignant neoplasms in children: an update from the Late Effects Study Group. J Clin Oncol 3:532–538.
Garre ML, Gandus S, Cesana B, et al. 1994. Health status of long-term survivors after cancer in childhood. Results of an uniinstitutional study in Italy. Am J Pediatr Hemat Oncol 16:143–152.
DeLaat CA, Lampkin BC. 1992. Long-term survivors of childhood cancer: evaluation and identification of sequelae of treatment (review) [see comments]. Cancer 42:263–282.
Neglia JP. 1994. Childhood cancer survivors. Past, present, and future (editorial). Cancer 73:2883–2885.
Green DM, Zevon MA, Reese PA, Lowrie GS, Michalek AM. 1994. Factors that influence the further survival of patients who survive for five years after the diagnosis of cancer in childhood or adolescence [see comments]; published erratum appears in Med Pediatr Oncol 1996 Jan;26(1):72]. Med Pediatr Oncol 22:91–96.
Robertson CM, Hawkins MM, Kingston JE. 1994. Late deaths and survival after childhood cancer: implications for cure. Br Med J 309:162–166.
Beer WH, Fan A, Halsted CH. 1985. Clinical and nutritional implications of radiation enteritis. Am J Clin Nutr 41:85–91.
Nicholson HS, Fears TR, Byrne J. 1994. Death during adulthood in survivors of childhood and adolescent cancer. Cancer 73:3094–3102.
Hawkins MM, Draper GJ, Winter DL. 1995. Cancer in the offspring of survivors of childhood leukaemia and non-Hodgkin lymphomas (see comments]. Br J Cancer 71:1335–1339.
Strong LC. 1993. Genetic implications for long-term survivors of childhood cancer. Cancer 71:3435–3440.
Green DM, Zevon MA, Lowrie G, Seigelstein N, Hall B. 1991. Congential anomalies in children of patients who received chemotherapy for cancer in childhood and adolescence [see comments]. N Engl J Medicine 325:141–146.
Potter R. 1993. Late side effects of pediatric radiotherapy (review). Recent Results Cancer Res 130:237–249.
Neuhauser EB, Willenborg MH, Berman CZ, Cohen J. 1952. Irradiation effects of roentgen therapy on the growing spine. Radiology 59:637–650.
Rate WR, Butler MS, Robertson WW Jr, D’Angio GJ. 1991. Late orthopedic effects in children with Wilms’ tumor treated with abdominal irradiation (see comments). Med Pediatr Oncol 19:265–268.
Kateman H, Waugh T, Berdon W. 1969. Skeletal changes following irradiation of childhood tumors. J Bone Joint Surg 51A:825–849.
Marcus RB, McGrath B, O’Conner K, Scarborough M. 1994. Long term effects on the musculoskeletal and integurmentary systems and the breast. In Schwartz CL, Hobbie WL, Constance LS, Ruccione KS (eds.). Survivors of Childhood Cancer. Assessment and Management. Mosby-Year Book.
Steinherz LJ, Sleinherz PG, Tan CT, Heller G, Murphy ML. 1991. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 266:1672.
Lipshultz SE, Colan SD, Gelber RD, Perez-Atayde AR, Sallan SE, Sanders SP. 1991. Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood [see comments]. N Engl J Med 324:808–815X.
Stewart JR, Fajardo LF. 1984. Radiation-induced heart disease: an update (review). Prog Cardiovasc Dis 27:173–194.
Trueschell S, Schwartz CL, Clark E, Constance LS. 1994. Cardiovascular effects of cancer therapy. In Schwartz CL, Hobbie WL, Constance LS, Ruccione KS (eds.), Survivors of Childhood Cancer. Assessment and Management. Mosby-Year Book.
Breslow NE, Takashima JR, Whitton JA, Moksness J, D’Angio GJ, Green DM. 1995. Second malignant neoplasms following treatment for Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 13:1851–1859.
Scaradavou A, Heller G, Sklar CA, Ren L, Ghavimi F. 1995. Second malignant neoplasms in long-term survivors of childhood rhabdomyosarcoma. Cancer 76:1860–1867.
Jakacki RI, Schramm CM, Donahue LR, Haas F, Allen JC. 1995. Restrictive lung disease following treatment for malignant brain tumors: a potential late effect of craniospinal irradiation. J Clin Oncol 13:1478–1485.
Meadows AT, Hobbie WL. 1986. The medical consequences of cure. Cancer 58:524–528.
Hancock SL, Donaldson SS, Hoppe RT. 1993. Cardiac disease following treatment of Hodgkin’s disease in children and adolescents [see comments]. J Clin Oncol 11:1208–1215.
Mulhern RK, Wasserman AL, Friedman AG, Fairclough D, 1989. Social competence and behavioral adjustment of children who are long-term survivors of cancer. Pediatrics 83:18–25.
Nicholson HS, Byrne J. 1993. Fertility and pregnancy after treatment for cancer during childhood or adolescence (review). Cancer 71:3392.
Packer RJ, Meadows AT, Rorke LB, Coldwein JL, D’Angio G. 1987. Long-term sequelae of cancer treatment on the central nervous system in childhood (review). Med Pediatr Oncol 15:241–253.
Duffner PK, Cohen ME, Thomas PR, Lansky SB. 1985. The long-term effects of cranial irradiation on the central nervous system. Cancer 56:1841–1846.
Glauser TA, Packer RJ. 1991. Cognitive deficits in long-term survivors of childhood brain tumors (review). Childs Nerv Sys 7:2–12.
Hays DM, Landsverk J, Sallan SE, et al. 1992. Educational, occupational, and insurance status of childhood cancer survivors in their fourth and fifth decades of life. J Clin Oncol 10:1397–1406.
Hearing on discrimination agains cancer victims and the handicapped; hearing on HR 192 and HR151 6; before the Subcommittee on Employment Opportunities of the House Commission on Education and Labor, 100th Congress 1st sessio 28:1987(statement) of Representative Morio Bragge, 31–33 and statement of Barbara Hoffman. 1987. National Coalition for Cancer Survivorship, pp. 41–53.
Koocher GP, O’Malley JE. 1982. The Damocles Syndrome: Psychological Consequences of Surviving Childhood Cancer. New York: McGraw Hill.
Moore IM, Packer RJ, Karl D, Bleyer WA. 1994. Adverse effects of cancer on the central nervous system. In Schwartz CL, Hobbie WL, Constance LS, Ruccione KS (eds.), Survivors of Childhood Cancer. Assessment and Management. Mosby-Year Book.
Cohen BH, Packer RJ. 1992. Adverse neurologic effects of chemotherapy and radiation therapy. In Berger BO (ed.). Neurologic Aspects of Pediatrics. Boston: Butterworth-Heinemann, pp. 567–594.
Nixon DW, Pirozzi D, York RM, Black M, Lawson DH. 1981. Dermatologie changes after systemic cancer therapy. Cutis 27:181–2.
Nixon DW, Pirozzi D, York RM, Black M, Lawson DH. 1981. Dermatologie changes after systemic cancer therapy. Cutis 27:186–188.
Rubin P. 1984. The Franz Buschke lecture: late effects of chemotherapy and radiation therapy: a new hypothesis (review). Int J Radiat Oncol Biol Phys 10:5–34.
Philips TL. 1989. Chemical modifiers of normal-tissue radiation injury (review). Front Radiat Ther Oncol 23:177–184.
Stewart FA. 1991. Keynote address: modulation of normal tissue toxicity by combined modality therapy: considerations for improving the therapeutic gain (review). Int J Radiat Oncol Biol Phys 20:319–325.
Peeters M, Poon A. 1987. Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity. Eur J Pediatr 146:416–422.
Ueland PM, Refsum H, Christensen B. 1990. Methotrexate sensitivity in Down’s syndrome: a hypothesis. Cancer Chemother Pharmacol 25:384–386.
Deschavanne PJ, Debieu D, Fertil B, Malaise EP. 1986. Re-evaluation of in vitro radiosensitivily of human fibroblasts of different genetic origins [published erratum appears in Int J Radiat Biol 1986 Dec;50(6):1129]. Int J Radiat Biol 50:279–293.
Gotoff SP, Amirmokri E, Liebner EJ. 1967. Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis. Am J Dis Child 114:617–625.
Cunlift PN, Mann JR, Cameron AH, Roberts KD, Ward HN. 1975. Radiosensitivity in ataxia-telangiectasia. Br J Radiol 48:374–376.
Malkin D, Jolly KW, Barbier N, et al. 1992. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms [see comments], N Engl J Med 326:1309–1315.
Pratt CB, Ransom JL, Evans WE. 1978. Age-related adriamycin cardioloxicity in children (review). Cancer Treat Rep 62:1381–1385.
Silber JH, Littman PS, Meadows AT. 1990. Stature loss following skeletal irradiation for childhood cancer. J Clin Oncol 8:304–312.
Anderson M, Green WT, Messner MB. 1978. The classic. Growth and predictions of growth in the lower extremities by Margaret Anderson, MS, William T, Green MD, and Marie Blail Messner AB, from the Journal of Bone and Joint Surgery, 45A:1, 1963. Clin Orthopaed Related Research 7–21.
Silber JH, Radcliffe J, Peckham V, et al. 1992. Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score (see comments]. J Clin Oncol 10:1390–1396.
Byrne J, Mutvihill JJ, Myers MH, et al. 1987. Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med 317:1315–1321.
Ash P. 1980. The influence of radiation on fertility in man (review). Br J Radiol 53:271–278.
Brauner R, Caltabiano P, Rappaport R, Leverger G, Schaison G. 1988. Leydig cell insufficiency after testicular irradiation for acute lymphoblastic leukemia. Horm Res 30:111–114.
Van Leeuwen FE, Somers R, Taal BG, et al. 1989. Increased risk of lung cancer, non-Hodgkin’s lymphoma, and leukemia following Hodgkin’s disease. J Clin Oncol 7:1046–1058.
Draper GJ, Sanders BM, Kingston JE. 1986. Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53:661–671.
Thomas PR, Griffith KD, Fineberg BB, Perez CA, Land VJ. 1983. Late effects of treatment for Wilms’ tumor. Int J Radiat Oncol Biol Phys 9:651–657.
Riseborough EJ, Grabias SL, Burton RI, Jaffe N. 1976. Skeletal alterations following irradiation for Wilms’ tumor: with particular reference to scoliosis and kyphosis. J Bone Joint Surg 58:526–536.
Simon MA, Aschliman MA, Thomas N, Mankin HJ. 1986. Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Sur 68:1331–1337.
Baumann M. 1995. Impact of endogenous and exogenous factors on radiation sequelae. In Dunst J, Daver R (eds.). Late Sequelae in Oncology. Springer-Verlag, pp. 3–12.
Packer RJ, Sposto R, Atkins TE, et al. 1987. Quality of life in children with primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Pediatr Neurosci 13:169–175.
Heyn R, Ragab A, Raney RB Jr, et al. 1986. Late effects of therapy in orbital rhabdomyosarcoma in children. A report from the Intergroup Rhabdomyosarcoma Study. Cancer 57:1738–1743X.
Osborne D, Hadden OB, Deeming LW, 1974. Orbital growth after childhood enucleation. Am J Ophthalmol 77:756–759.
Punt J, Pritchard J, Pincott JR, Till K. 1980. Neuroblastoma: a review of 21 cases presenting with spinal cord compression. Cancer 45:3095–3101.
Laros C, Westerman C. 1987. Dilatation, compensatory growth or both after pneu-monectomy during childhood and adolescence. Cardiovasc Surg 93:570.
Krivit W, Giebink GS, Leonard A. 1979. Overwhelming postplenectomy infection. Surg Clin North Am 59:223–233.
Blatt J, Bleyer A. 1989. Late effects of childhood cancer and its treatment. In Pizzo P, Poplack DG (eds.), Principles and Practice of Pediatric Oncology. Philadalphia: J.B. Lippincott, pp. 1003–1026.
Zinchke H, Segura JW. 1975. Ureterosigmoidostoray: critical review of 173 cases. J Urol 113:324–327.
Javadpour N, Moley J. 1985. Alternative to retroperitoneal lymphadenectomy with preservation of ejaculation and fertility in stage I nonseminomatous testicular cancer. A prospective study. Cancer 55:1604–1606.
Nicosia SV, Matus-Ridley M, Meadows AT. 1985. Gonadal effects of cancer therapy in girls. Cancer 55:2364–2372.
Donahue B. 1992. Short- and long-term complications of radiation therapy for pediatric brain tumors (review). Pediatr Ncurosurg 18:207–217.
Duffner PK, Cohen ME. 1991. The long-term effects of central nervous system therapy on children with brain tumors (review). Neurol Clin 9:479–495.
Chung E, Bodensteiner J, Hogg JP. 1992. Spontaneous intracerebral hemorrhage: a very late delayed effect of radiation therapy. J Child Neurol 7:259–263.
Allen JC, Miller DC, Budzilovich GN, Epstein FJ. 1991. Brain and spinal cord hemorrhage in long-term survivors of malignant pediatric brain tumors: a possible late effect of therapy. Neurology 41:148–150.
Oberfield SE, Allen JC, Pollack J, New MI, Levine LS. 1986. Long-term endocrine sequelae after treatment of medulloblastoma: prospective study of growth and thyroid function. J Pediatr 108:219–223.
Shapiro E, Kinsella TJ, Makuch RW, et al. 1985. Effects of fractionated irradiation of endocrine aspects of testicular function. J Clin Oncol 3:1232–1239.
Shalet SM, Beardwell CG, Jacobs HS, Pearson D. 1978. Testicular function following irradiation of the human prepubertal testis. Clin Endocrinol 9:483–490.
Sklar CA, Robison LL, Nesbit ME, et al. 1990. Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Children Cancer Study Group. J Clin Oncol 8:1981–1987.
Blatt J, Copeland DR, Bleyer WA. 1997. Late effects of childhood cancer and its treatment. In Pizzo P, Poplack DG (eds.), Principles and Practice of Pediatric Oncology, 2nd ed Philadelphia: J.B. Lippincott.
Makipernaa A, Heikkila JT, Merikanto J, Marttinen E, Siimes MA. 1993. Spinal deformity induced by radiotherapy for solid tumours in childhood: a long-term follow up study. Eur J Pediatr 152:197–200.
Jaffe N, Toth BB, Hoar RE, Ried HL, Sullivan MP, McNeese MD. 1984. Dental and maxillofacial abnormalities in long-term survivors of childhood cancer: effects of treatment with chemotherapy and radiation to the head and neck. Pediatrics 73:816–823.
Fromm M, Littman P, Raney RB, et al. 1986. Late effects after treatment of twenty children with soft tissue sarcomas of the head and neck. Experience at a single institution with a review of the literature. Cancer 57:2070–2076.
Merriam GR, Focht EF. 1957. A clinical study of radiation cataracts and the relationship to dose. Am J Roentgenol 77:759–785.
Hawkins MM, Wilson LM, Stovall MA, et al. 1992. Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer. Br J Med 304:951–958.
Ellis M, Ravid M, Lishner M. 1993. A comparative analysis of alkylating agent and epipodophyllotoxin-related leukemias (review). Leuk Lymphoma 11:9–13.
Schilsky RL, Sherins RJ. 1982. Gonadal dysfunction. In Devita VT Jr, Hellman S, Rosentberg SA (eds.), Cancer: Principles and Practice of Oncology. Philadelphia: J.B. Lippincott, pp. 1713–1719.
Sherins RJ, DeVita VT Jr. 1973. Effect of drug treatment for lymphoma on male reproductive capacity. Studies of men in remission after therapy. Ann Intern Med 79:216–220.
Sherins RJ, Olweny CL, Ziegler JL. 1978. Gynecomastia and gonadal dysfunction in adolescent boys treated with combination chemotherapy for Hodgkin’s disease. N Engl J Med 299:12–16.
Whitehead E, Shalet SM, Jones PH, Beardwell CG, Deakin DP. 1982. Gonadal function after combination chemotherapy for Hodgkin’s disease in childhood. Arch Dis Child 57:287–291.
Travis LB, Curtis RE, Glimelius B, et al. 1995. Bladder and kidney cancer following cyclophosphamide therapy for non-Hodgkin’s lymphoma. J Nat Cancer Inst 87:524–530.
Klein HO, Wickramanayake PD, Coerper C, Christian E, Pohl J, Brock N. 1983. High-dose ifosfamide and mesna as continuous infusion over five days — a phase I/II trial. Cancer Treat Rev 10(Suppl A): 167–173.
Stillwell TJ, Benson RC Jr, Burgert EO Jr. 1988. Cyclophosphamide-induced hemorrhagic cystitis in Ewing’s sarcoma. J Gin Oncol 6:76–82.
Jules-Elysee K, White DA. 1990. Bleomycin-induced pulmonary toxicity (review). Clin Chest Med 11:1–20.
Edwards GS, Lane M, Smith FE. 1979. Long-term treatment with cisdichlorodiam-minplatinum(II)-vinblastine-bleomycin: possible association with severe coronary artery disease (letter). Cancer Treat Rep 63:551–552.
Arsenian MA. 1991. Cardiovascular sequelae of therapeutic thoracic radiation (review). Prog Cardiovasc Dis 33:299–311.
Larsen RL, Jakacki RI, Vetter VL, Meadows AT, Silber JH, Barber G. 1992. Electrocardiographic changes and arrhythmias after cancer therapy in children and young adults. Am J Cardiol 70:73–77.
Dahl MG, Gregory MM, Scheuer PJ. 1971. Liver damage due to methotrexate in patients with psoriasis. Br Med J 1:625–630.
McIntosh S, Davidson DL, O’Brien RT, Pearson HA. 1977. Methotrexate hepatotoxicity in children with leukemia. J Pediatr 90:1019–1021.
Neumann Y, Toren A, Rechavi G, et al. 1996. Vincristine treatment triggering the expression of asymptomatic Charcot-Marie-Tooth disease. Med Pediatr Oncol 26:280–283.
Hansen SW, Helweg-Larsen S, Trojaborg W. 1989. Long-term neurotoxicity in patients treated with cisplatin, vinblastine, and bleomycin for metastatic germ cell cancer. J Clin Oncol 7:1457–1461.
Redman JR, Bajorunas DR, Wong G, et al. 1988. Bone mineralization in women following successful treatment of Hodgkin’s disease. Am J Med 85:65–72.
Sullivan KM, Agura E, Anasetti C, et al. 1991. Chronic graft-versus-host disease and other late complications of bone marrow transplantation (review). Semin Hematol 28:250–259.
Shulman HM, Sullivan KM, Weiden PL, et al. 1980. Chronic graft-versus-host syndrome in man. A long-term clinicopalhologic study of 20 Seattle patients. Am J Med 69:204–217.
Maguire A, Craft AW, Evans RG, et al. 1987. The long-term effects of treatment on the dental condition of children surviving malignant disease. Cancer 60:2570–2575.
Marcial V. 1989. The oral cavity and oropharynx. In Moss WT, Cox JD (eds.), Radiation Oncology. St. Louis: Mosby-Year Book.
Brady LW, Shields J, Augusburger J, Markoe A, Karlsson UL. 1989. Complications from radiation therapy to the eye. Front Radiat Ther Oncol 23:238–250.
Hughes BR, Cunliffe WJ, Bailey CC. 1989. Excess benign melanocytic naevi after chemotherapy for malignancy in childhood. Br Med J 299:88–91.
Green A, Smith P, McWhirter W, et al. 1993. Melanocytic naevi and melanoma in survivors of childhood cancer. Br J Cancer 67:1053–1057.
Meadows AT, Fenton JG. 1994. Follow up care of patients at risk for the development of second malignant neoplasms. In Schwartz CL, Hobbie WL, Constine LS, Ruccione KS (eds.), Survivors of Childhood Cancer: Assessment and Management. St. Louis: Mosby-Year Book, pp. 319–328.
Skinner R, Pearson AD, Price L, Coulthard MG, Craft AW. 1990. Nephrotoxicity after ifosfamide. Arch Dis Child 65:732–738.
Ragab AH, Freeh RS, Vietti TJ. 1970. Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer 25:580–585.
Rosenfield NS, Haller JO, Berdon WE. 1989. Failure of development of the growing breast after radiation therapy. Pediatr Radiol 19:124–127.
Libshitz HI, Edeiken BS. 1981. Radiotherapy changes of the pediatric hip. AJR 137:585–58X.
Dickerman JD, Newberg AH, Moreland MD. 1979. Slipped capital femoral epiphysis (SCFE) following pelvic irradiation for rhabdomyosarcoma. Cancer 44:480–482.
Laurel J, Steinhertz L, Steinhertz P. 1988. Cardiac failure more than six years post anthracylcines (abstract). Am J Cardiology 62:505.
Davis LE, Brown CE. 1988. Peripartum heart failure in a patient treated previously with doxorubicin. Obstet Gynecol 71:506–508.
Billingham ME, Mason JW, Bristow MR, Daniels JR. 1978. Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep 62:865–872.
Martin RG, Ruckdeschel JC, Chang P, Byhardt R, Bouchard RJ, Wiernik PH. 1975. Radiation-related pericarditis. Am J Cardiol 35:216–220.
McReynolds RA, Gold GL, Roberts WC. 1976. Coronary heart disease after mediastinal irradiation for Hodgkin’s disease. Am J Med 60:39–45.
Gross NJ. 1977. Pulmonary effects of radiation therapy (review). Ann Intern Med 86:81–92.
Wohl ME, Griscom NT, Traggis DG, Jaffe N. 1975. Effects of therapeutic irradiation delivered in early childhood upon subsequent lung function. Pediatrics 55:507–516.
Ali MK, Ewer MS, Gibbs HR, Swafford J, Graff KL. 1994. Late doxorubicin-associated cardiotoxicity in children. The possible role of intercurrent viral infection. Cancer 74:182–188.
Bhisitkul DM, Morgan ER, Vozar MA, Langman CB. 1991. Renal functional reserve in long-term survivors of unilateral Wilms tumor. J Pediatr 118:698–702.
Van Slyck EJ, Bermudez GA. 1968. Radiation nephritis. Yale J Biol Med 41:243–256.
Vogelzang NJ. 1991. Nephrotoxicity from chemotherapy: prevention and management (review). Oncology 5:97–102.
Kaufman JJ. 1984. Ammoniagenic coma following ureterosigmoidostomy. J Urol 131:743–745.
Hays DM. 1989. General principles of surgery. In Pizzo PA, Poplack DC (eds.), Principles and Practice of Pediatric Oncology. Philadelphia: J.B. Lippincott, pp. 207–232.
Wellwood JM, Jackson BT. 1973. The intestinal complications of radiotherapy. Br J Surg 60:814–818.
Tefft M, Mitus A, Das L, Vawter GF, Filler RM. 1970. Irradiation of the liver in children: review of experience in the acute and chronic phases, and in the intact normally resected. AJR 108:365–385.
Vernant JP. 1986. Hepatitis B and non-A-non-B hepatitis after allogeneic bone marrow transplantation in leukemia. Bone Marrow Transplant 1:183–184.
Raney B Jr, Heyn R, Hays DM, et al. 1993. Sequelae of treatment in 109 patients followed for 5 to 15 years after diagnosis of sarcoma of the bladder and prostate. A report from the Intergroup Rhabdomyosarcoma Study Committee. Cancer 71:2387–2394.
Brown IH, Lee TJ, Eden OB, Bullimore JA, Savage DC. 1983. Growth and endocrine function after treatment for medulloblastoma. Arch Dis Child 58:722–727.
Constine LS, Woolf PD, Cann D, et al. 1993. Hypothalamie-pituitary dysfunction after radiation for brain tumors [published erratum appears in N Engl J Med 1993 Apr 22;328(16):1208; sec comments]. N Engl J Med 328:87–94.
Lushbaugh CC, Casarett GW. 1976. The effects of gonadal irradiation in clinical radiation therapy: a review. Cancer 37:3111–1125.
Holmes GE, Holmes FF. 1978. Pregnancy outcome of patients treated for Hodgkin’s disease: a controlled study. Cancer 41:1317–1322X.
Vogel F. 1979. Genetics of retinoblastoma (review). Hum Genet 52:1–54.
Li FP, Fraumeni JF Jr. 1969. Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 71:747–752.
Li FP, Fraumeni JF Fr. 1969. Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. J Natl Cancer Inst 43:1365–1373.
Li FP, Winston KR, Gimbrere K. 1984. Follow-up of children with brain tumors. Cancer 54:135–138.
Tamareff M, Saliven R, Miller DR. 1984. Compaison of neuropsychologic performance in children treated for acute lymphoblastic leukemia with 1800 rads cranial radiation plus intrathecal methotrexate or intrathecal methotrexate alone (abstract). Proc Am Soc Clin Oncol 3:198.
Sheline GE, Wara WM, Smith V. 1980. Therapeutic irradiation and brain injury (review). Int J Radiat Oncol Biol Phys 6:1215–1218.
Pizzo PA, Poplack DG, Bleyer WA. 1979. Neurotoxicities of current leukemia therapy (review). Am J Pediatr Hematol-Oncol 1:127–140.
Hawkins MM, Draper GJ, Kingston JE. 1987. Incidence of second primary tumours among childhood cancer survivors. Br J Cancer 56:339–347.
Li FP, Corkery J, Vawter G, Fine W, Sallan SE. 1983. Breast carcinoma after cancer therapy in childhood. Cancer 51:521–523.
Beaty O, Hudson MM, Greenwald C, et al. 1995. Subsequent malignancies in children and adolescents after treatment for Hodgkin’s disease [see comments]. J Clin Oncol 13:603–609.
Tucker MA, Meadows AT, Boice JD Jr, et al. 1987. Leukemia after therapy with alkylating agents for childhood cancer. J Natl Cancer Inst 78:459–464.
Pui CH, Hancock ML, Raimondi SC, et al. 1990. Myeloid neoplasma in children treated for solid tumors. Lancet 336:417–421.
Springfield DS, Pagliarulo C. 1985. Fractures of long bones previously treated for Ewing’s sarcoma. J Bone Joint Surg 67:477–418.
Heyn R, Newton WA, Ragab A. 1987. Second malignant neoplasms in patients treated on the Intergroup Rhabdomyosarcoma Study I–II (abstract). Proc Assoc Soc Clin Oncol 5:215.
Wasserman AL, Thompson EI, Wilimas JA, Fairclough DL. 1987. The psychological status of survivors of childhood/adolescent Hodgkin’s disease. Am J Dis Child 141:626–631.
Mullen F. 1984. The educational needs of the cancer survivor. Health Educ Q (Suppl) 10:88–94.
Mulhern RK, Tyc VL, Phipps S, et al. 1995. Health-related behaviors of survivors of childhood cancer. Med Pediatr Oncol 25:159–165.
Bleyer WA. 1990. The impact of childhood cancer on the United States and the world. Cancer 40:355–367.
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Morgan, E.R., Haugen, M. (1997). Late effects of cancer therapy. In: Walterhouse, D.O., Cohn, S.L. (eds) Diagnostic and Therapeutic Advances in Pediatric Oncology. Cancer Treatment and Research, vol 92. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5767-8_11
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