Abstract
Hypoxic cancer cells are resistant to irradiation and to some types of chemotherapy. When these methods are used to treat tumors, presence of small hypoxic regions can compromise the outcome. Therefore, it is important to understand the factors determining the partial pressure of oxygen (pO2) in tumors at the microscopic level. These factors include the oxygen supply to the tumor, which depends on the flow rate and oxygen content of blood and the arrangement of microvessels within the tissue, and the rate of oxygen consumption by the tissue (Vaupel, 1979).
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Dewhirst, M.W., Ong, E.T., Klitzman, B., Secomb, T.W., Vinuya, R.Z., Dodge, R., Brizel, D and Gross, J.F., 1992, Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber. Radiation Res. 130: 171–182.
Dewhirst, M.W., Secomb, T.W., Ong, E.T., Hsu, R. and Gross, J.F., 1994, Determination of local oxygen consumption rates in tumors. Cancer Res. 54: 3333–3336.
Dische, S., 1978, Hyperbaric oxygen: The Medical Research Council trials and their clinical significance. Br. J. Radiol. 51:888–894.
Hsu, R. and Secomb, T.W., 1989, A Green’s function method for analysis of oxygen delivery to tissue by microvascular networks. Math. Biosciences 96: 61–78.
Jirtle, R.L., 1988, Chemical modification of tumour blood flow. Int. J. Hyperthermia 4: 355–372.
Papenfuss, H.D., Gross, J.F., Intaglietta, M., and Treese, F.A., 1979, A transparent access chamber for the rat dorsal skin fold. Microvasc. Res. 18: 311–318.
Secomb, T.W., Hsu, R., Dewhirst, M.W., Klitzman, B. and Gross, J.F., 1993, Analysis of oxygen transport to tumor tissue by microvascular networks. Int. J. Rad. Onc. Biol. Phys. 25: 481–489.
Secomb, T.W., Hsu, R., Ong, E.T., Gross, J.F. and Dewhirst, M.W., 1995, Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncologica 34: 313–316.
Thews, O., Kelleher, D.K. and Vaupel, P., 1996, In vivo consumption rate of DS sarcoma cells on inhibition of DNA synthesis. Cancer Res. 56: 2009–2012.
Vaupel, P., 1979, Oxygen supply to malignant tumors. In: Peterson, H-I, ed., Tumor Blood Circulation. Boca Raton, FL: CRC Press, pp. 143–168.
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Secomb, T.W., Hsu, R., Braun, R.D., Ross, J.R., Gross, J.F., Dewhirst, M.W. (1998). Theoretical Simulation of Oxygen Transport to Tumors by Three-Dimensional Networks of Microvessels. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_74
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DOI: https://doi.org/10.1007/978-1-4615-4863-8_74
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