Summary
We conclude that a global ischemic/hypoxic insult results in a heterogeneous response of mechanical and mitochondrial performance in isolated Langendorff-perfused hearts. The results warn against the use of models of stunning in which stunning is determined for only one part (e.g. left ventricle) and effects of stunning are analyzed in other parts (e.g. right ventricular muscle). The results further suggest that some parts of the myocardium under some mechanical loading conditions can withstand 15 min of interrupted oxygen supply without strong negative effects on contractile function and the response time of oxidative phosphorylation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Beek, J.H.G.M. van, Westerhof, N., 1991 Response time of cardiac mitochondrial oxygen consumption to heart rate steps, Am. J. Physiol. 260:H613–H625.
Beek, J.H.G.M. van, Loiselle, D.S., Westerhof, N., 1992 Calculation of oxygen diffusion across the surface of isolated perfused hearts, Am. J. Physiol. 263:H1003–H1010.
Dietrich, D.L., Elzinga, G., 1990 Energy demand, supply, and utilization in hypoxia, and force recovery after reoxygenation in rabbit heart muscle, Circ. Res. 67:1089–1096.
Dietrich, D.L., Van Leeuwen, G.R., Stienen, G.J.M., and Elzinga, G., 1993 Stunning does not change the relation between calcium and force in skinned rat trabeculae, J. Mol. Cell. Cardiol. 25:541–549.
Hak, J.B., van Beek J.H.G.M., van Wijhe M.H., Westerhof N., 1992 Influence of temperature on the response time of mitochondrial oxygen consumption in isolated rabbit heart, J. Physiol. 447:17–31.
Kretzschmar, K.M., Wilkie, D.R., 1972 A new method for absolute heat measurements, utilizing the Peltier effect, J. Physiol.:18p–20p.
Mast, F., Elzinga, G., 1988 Recovery heat production of isolated rabbit papillary muscle at 20 °C, Pflüg. Arch. 411:600–605.
Mast, F., Woledge, R.C., Elzinga, G., 1990 Analysis of thermopile records from contracting isolated cardiac muscle, Am. J. Physiol. 259:H1601–H1605.
Miller, W.P., McDonald, K.S., Moss, R.L., 1996, Onset of reduced Ca2+ sensitivity of tension during stunning in porcine myocardium. J. Moll. Cell. Cardiol. 28:689–697.
Mulieri, L.A., Luhr, G., Trefy, J., Alpert, N.R., 1977 Metal-film thermopiles for usage with rabbit right ventricular papillary muscles, Am. J. Physiol. 233:C146–C156.
Zuurbier, C.J., Van Beek, J.H.G.M., Mast, F., Elzinga, G., 1997a Mitochondrial function is not decreased in stunned papillary muscle at 20 °C, J. Mol. Cell. Cardiol. 29:347–355.
Zuurbier, C.J., Van Beek J.H.G.M., 1997b Mitochondrial response to heart rate steps in isolated rabbit heart is slowed after myocardial stunning, Circ. Res. 81:69–75.
Zuurbier, C.J., Van Beek, J.H.G.M., 1997c Undiminished mitochondrial function after 25 min ischemia with pacing in rabbit heart at 28°C despite stunning, Cardiov. Res. 35:113–119.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Zuurbier, C.J., van Beek, J.H.G.M. (1998). Papillary Muscle and Left Ventricle Show Different Contractile and Metabolic Responses During Myocardial Stunning. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_62
Download citation
DOI: https://doi.org/10.1007/978-1-4615-4863-8_62
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7206-6
Online ISBN: 978-1-4615-4863-8
eBook Packages: Springer Book Archive