Abstract
The adaptation of cardiac oxidative phosphorylation to changing cardiac work load has been investigated in many ways, but the precise regulatory mechanisms are still unknown. Our laboratory has focused on the time course of the first phase of the response of cardiac oxidative phosphorylation and high-energy phosphates in response to quick changes in cardiac workload. 1,2 To quantitate the time course of the response of oxidative phosphorylation to changed ATP hydrolysis, we determine the response time of cardiac mitochondrial oxygen consumption (tmito ), by correcting the response of coronary venous oxygen concentration for diffusion and intravascular delays and for oxygen dissociation from myoglobin.1
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Tian, X., van Beek, J.H.G.M. (1998). Response Time of Myocardial Oxygen Consumption to Cardiac Work Jumps at 28°C Varies with Exogenous Carbon Substrate. In: Hudetz, A.G., Bruley, D.F. (eds) Oxygen Transport to Tissue XX. Advances in Experimental Medicine and Biology, vol 454. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4863-8_60
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