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Identification and Characterization of an Enhancer Sequence in the Promoter Region of Human 15-Lipoxygenase (15-LO) Gene

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 469))

Abstract

Lipoxygenases are lipid-peroxidating enzymes that are implicated in the pathogenesis of a variety of inflammatory disorders 1-3, membrane remodeling 4-6 and atheroma formation 7-9. Formation of 15-(S)-hydroxyeicosatetraenoic acid [15-(S)-HETE] and lipoxin (LX) A4 in human leukocytes, mediated by 15-LO dependent catalysis of arachidonic acid, likely represents a component of endogenous pro- and anti-inflammatory influences that ultimately regulate the extent and severity of inflammatory reactions 1-4, 10.

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References

  1. B. Samuelsson, SE. Dahin, J.A. Lindgren, C.A. Rouzer, and C.N. Serhan, Science 7:1171 (1987)

    Article  Google Scholar 

  2. A. Ford-Hutchinson, Eicosanoids 4: 65–74 (1991)

    PubMed  CAS  Google Scholar 

  3. K.F. Badr, Kidney Int. 442: S101–S108 (1992)

    Google Scholar 

  4. S. M. Rapoport and T. Schewe, Biochim. Biophys. Acta. 864, 471–495 (1986)

    Article  PubMed  CAS  Google Scholar 

  5. H. Kuhn, J. Belkner, R. Wiesner and A.R. Brash, J. Biol Chem. 265: 18351–18361 (1990)

    PubMed  CAS  Google Scholar 

  6. J.J. Murray and A.R. Brash, Arch. Biochem. Biophys. 265: 514–523 (1988)

    Article  PubMed  CAS  Google Scholar 

  7. C.P. Sparrow, S. Parthasarathy and D.J. Steinberg, Lipid Res. 29: 745–753 (1988)

    CAS  Google Scholar 

  8. S. Yla-Herttuala, M.E. Rosenfeld, S. Parthasarathy, C.K. Glass, E. U.S.A. 87: 6959–6963 (1991)

    Article  Google Scholar 

  9. S. Yla-Herttuala, M.E. Rosenfeld, S. Parthasarathy, E. Sigal, T. Sarkioja, J.L. Witztum and D.J. Steinberg, J. Clin. Invest.87: 1146–1152 (1991)

    Article  PubMed  CAS  Google Scholar 

  10. C.N. Serhan, Biochim. Biophy. Acta. 12: 1–25 (1994)

    Google Scholar 

  11. M.E. Brezinski and C.N. Serhan, ProcAcad. Natl. Sci.U.S.A. 87: 6248–6252 (1990)

    Article  CAS  Google Scholar 

  12. D.B. Fischer, J.W. Christman and K.F. Badr, Kidney Int. 41: 1155–1160 (1992)

    Article  PubMed  CAS  Google Scholar 

  13. A.B. Legrand, J.A. Lawson, B.O. Meyrick, I.A. Blair and J.A. Oates, J. Biol. Chem. 266: 7570–7577 (1991)

    PubMed  CAS  Google Scholar 

  14. S. Fiore, J.F. Maddox, H. Daniel Perez and C.N. Serhan, J. Exp. Med. 180: 253–260 (1994)

    Article  PubMed  CAS  Google Scholar 

  15. T.R. Mosmann and R.L. Coffman, Annu. Rev. Immunol. 7: 145–173 (1989)

    Article  PubMed  CAS  Google Scholar 

  16. F. Powrie and R.L. Coffman, Immunol. Today. 14: 270–274 (1993)

    Article  PubMed  CAS  Google Scholar 

  17. A. Minty, P. Chalon, J-M. Derocq, X. Dumont, J-C. Guillemot, M. Kaghad, C. Labit, P. Leplatois, P. Liauzun, B. Miloux, C. Minty, P. Casellas, G. Loison, J. Lupker, S. Shire, P. Ferrara and D. Caput, Nature 362: 248–250 (1993)

    Article  PubMed  CAS  Google Scholar 

  18. A.N.J. McKenzie, J.A. Culpepper, R. De Waal Malefyt, F. Briere, J. Punnonen, G. Aversa, A. Sato, W. Dang, B.G. Cocks, S. Menon, J.E. De Vries, J. Banchereau and G. Zurawski, Proc. Natl Acad. Sci. U.S.A.90: 3735–3739 (1993)

    Article  PubMed  CAS  Google Scholar 

  19. R. De Waal Malefyt, C.G. Figdor, R. Huijbens, S. Mohan-Paterson, B. Bennett, J. Culpepper, W. Dang, G. Zurawski and J.E. De Vries, J. Immunol.151: 6370–6381 (1993)

    PubMed  Google Scholar 

  20. H.L. Wong, G.L. Costa, M.T. Lotze and S.M. Wahl, J. Exp. Med. 177: 775–781 (1993)

    Article  PubMed  CAS  Google Scholar 

  21. D.F. Fiorentino, A. Zlotnik, T.R. Mosmann, M.H. Howard and A. O’Garra, J. Immunol. 147:3815–3822 (1991)

    PubMed  CAS  Google Scholar 

  22. D.J. Conrad, H. Kuhn, M. Mulkins, E. Highland and E. Sigal, Proc. Acad. Sci. U.S.A. 89: 217–221 (1992)

    Article  CAS  Google Scholar 

  23. B.D. Levy, M. Romano, H.A. Chapman, J.J. Reilly, J. Drazen and C.N. Serhan, J. Clin. Invest. 92:1572–1579 (1993)

    Article  PubMed  CAS  Google Scholar 

  24. G.M. Nassar, J.M. Morrow, L.J. Roberts H, F.G. Lakkis and K.F. Badr, J. Biol. Chem. 269: 27631–27634 (1994)

    PubMed  CAS  Google Scholar 

  25. J. Fleming, B.J. Thiele, J. Chester, J. O’Prey, S. Janetzki, A. Aitken, I.A. Anton, S.M. Rapoport and P.R. Harrison, Gene 79: 181–188 (1989)

    Article  PubMed  CAS  Google Scholar 

  26. E. Sigal, C.S. Craik, E. Highland, D. Grunberger, L.L. Costello, R.A.F. Dixon and J.A. Nadel, Biochem. Bioph Res. Comm. 157: 457–464 (1989)

    Article  Google Scholar 

  27. T. Yoshimoto, T. Arakawa, T. Hada, S. Yamamoto and E. Takahashi, J. Biol. Chem. 267: 24805–24809 (1992)

    PubMed  CAS  Google Scholar 

  28. S. Hoshiko, O. Raadmark and B. Samuelsson, Proc. Natl. Acad. Sci. U.SA. 87: 9073–9077 (1990)

    Article  CAS  Google Scholar 

  29. I. Köhler and E.P. Rieber, Eur. J. Immunol. 23: 3066–3071 (1993)

    Article  PubMed  Google Scholar 

  30. J. Hou, U. Schindler, W.J. Henzel, T.C. Ho, M. Brasseur and S.L. McKnight, Science. 265: 1701–1706 (1994)

    Article  PubMed  CAS  Google Scholar 

  31. I. Köhler, P. Alliger, A. Minty, D. Caput, P. Ferrara, B.H. Neugebauer, G. Rank and E.P. Rieber, FEBS. Lett. 345:187–192 (1994)

    Article  PubMed  Google Scholar 

  32. T. Taniguchi, Science. 268: 251–255 (1995)

    Article  PubMed  CAS  Google Scholar 

  33. J. Sambrook, E.F. Fritsch and T. Maniatis, Molecular cloning: A laboratory manual, 2nd Ed., Cold Spring Harbor Laboratory Press,Plainview, New York (1989)

    Google Scholar 

  34. J.D. Dignam, R.M. Labovitz and R.G. Roeder, Nucleic Acids Res. 11: 1475–1489 (1983)

    Article  PubMed  CAS  Google Scholar 

  35. G.E. Austin, W.G. Zhao, W. Zhang, E.D Austin, H.W. Findlev and J. Murtagh, Leukemia. 9: 848–857 (1995)

    PubMed  CAS  Google Scholar 

  36. DNA sequence input and analysis software system for PC-DOS: Ver VIII C0410-604 (1991)

    Google Scholar 

  37. S. Altschul, W. Gish, M. Webb, E. Myers and D.J. Lipman, J. Mol. Biol. 215:403–410. (1990)

    PubMed  CAS  Google Scholar 

  38. U. Kelavkar, S. Wang, A. Montero, J. Murtagh, K. Shah and K. Badr, Mol. Biol.Reports, 25:1–10 (1998)

    Article  Google Scholar 

  39. S.T. Smale and D. Baltimore, Cell 57:103–113 (1989)

    Article  PubMed  CAS  Google Scholar 

  40. K.L. Luskey, Mol. Cell. Biol. 7: 1881–1899 (1987)

    Google Scholar 

  41. Y. Li, S. Camp, T.L. Rachinsky, C. Bongiorno and P. Taylor, J. Biol. Chem. 268: 3563–3572 (1993)

    PubMed  CAS  Google Scholar 

  42. C. Funk, L. Funk, G. FitzGerald and B. Samuelsson, Proc. Natl. Acad. Sci. USA. 89: 3962–3966 (1992)

    Article  PubMed  CAS  Google Scholar 

  43. T. Katoh, F. Lakkis, N. Makita and K. Badr, Kidney Int. 46: 341–349 (1994)

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Renal Division, Emory University, and Center for Glomerulonephritis, Veterans Affairs Medical Center, Atlanta, GA, 30322, USA

    Uddhav Kelavkar, Susheng Wang, Angel Montero & Kamal Badr

Authors
  1. Uddhav Kelavkar
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  2. Susheng Wang
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  3. Angel Montero
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  4. Kamal Badr
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California at San Diego, San Diego, California, USA

    Edward A. Dennis

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© 1999 Springer Science+Business Media New York

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Kelavkar, U., Wang, S., Montero, A., Badr, K. (1999). Identification and Characterization of an Enhancer Sequence in the Promoter Region of Human 15-Lipoxygenase (15-LO) Gene. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E.A. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4. Advances in Experimental Medicine and Biology, vol 469. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4793-8_11

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  • DOI: https://doi.org/10.1007/978-1-4615-4793-8_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7171-7

  • Online ISBN: 978-1-4615-4793-8

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