Abstract
This chapter briefly discusses the salient features of models of breast carcinogenesis. It is intended not to be an extensive encyclopedia of all models in the literature but to emphasize key features of the main models. The information presented here is very much the authors’ interpretations of selected data in the literature, which, hopefully, will stimulate spirited discussion and new ideas.
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Abbreviations
- LDH:
-
loss of heterozygosity
- DCIS:
-
ductal carcinoma in situ
References
D. Medina (2000). Mouse models for mammary cancer. Chapter 1, this volume.
H. J. Thompson (2000). Methods for the induction of mammary carcinognesis in the rat using either 7,12dimethylbenzanthracene or 1-methyl- 1-nitrosourea. Chapter 2, this volume.
M. Tokunaga, C. E. Land, S. Tokuoka, I. Nishimori, M. Soda, and S. Akiba (1994). Incidence of female breast cancer among atomic bomb survivors, 1950–1985. Radiation Res. 138: 209–223.
R. D. Cardiff and S. R. Wellings (1999). The comparative pathology of human and mouse mammary glands. J. Mam. Gland Biol. Neoplasia 4: 105–122.
S. Nandi, R. C. Guzman, and J. Yang (1995). Hormones and mammary carcinogenesis in mice, rats and humans: a unifying hypothesis. Proc. Natl. Acad. Sci. USA 92: 3650–3657.
W. Kim (1970). Metastasizing mammary carcinomas in rats: induction and study of their immunogenicity. Science 167: 72–74.
J. D. Haag, G. M. Brasic, L. A. Shepel, M. A. Newton, C. J. Grubbs, R. A. Lubet, G. J. Kelloff, and M. N. Gould (1999). A comparative analysis of allelic imbalance events in chemically induced rat mammary, colon and bladder tumors. Mol. Carcinogenesis 24: 47–56.
P. O’Connell, V. Pekkel, S. A. W. Fuqua, C. K. Osborne, and D. C. Allred (1998). Analysis of loss of heterozygosity in 399 premalignant breast lesions at 15 genetic loci. J. Natl. Cancer Inst. 90: 697–703.
Y. Dong, H. L. Asch, D. Medina, C. Ip, M. M. Ip, R. Guzman, and B. B. Asch (1999). Concurrent deregulation of gelsolin and cyclin D1 in the majority of human and rodent breast cancers. Int. J. Cancer 81: 930–938.
C. A. MacArthur, D. B. Shankar, and G. M. Shackleford (1995). Fgf-8, activated by proviral insertion, cooperates with the wnt-I transgene in murine mammary tumorigenesis. J. Viral. 69: 2501–2507.
E. L. Huguet, J. A. McMahon, A. P. McMahon, R. Bicknell, and A. L. Harris (1994). Differential expression of human Wnt genes 2, 3, 4 and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 54: 2615–2621.
R. B. Dickson and M. E. Lippman (1995). Growth factors in breast cancer. Endocrine Rev. 16: 559–589.
P. E. Goss and S. Sierra (1998). Current perspectives on radiation-induced breast cancer. J Clin. Oncol. 16: 338–347.
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Medina, D., Thompson, H.J. (2000). A Comparison of the Salient Features of Mouse, Rat, and Human Mammary Tumorigenesis. In: Ip, M.M., Asch, B.B. (eds) Methods in Mammary Gland Biology and Breast Cancer Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4295-7_3
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DOI: https://doi.org/10.1007/978-1-4615-4295-7_3
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