Abstract
The notion one has of the fluorocarbon-based approach to injectable oxygen carriers is still too often associated with the earlier Fluosol®-type emulsions. The fact that Fluosol has been approved, although only for a limited number of applications, as an adjunct during percutaneous transluminal coronary angioplasty (PTCA), means that the intravascular administration of fluorocarbon emulsions is considered safe by the FDA, and that oxygen transport capacity has been recognized for this preparation, in spite of its low concentration and other limitations.1 Very similar 20% w/v concentrated emulsions have been developed in the Soviet Union and in China under the names Ftorosan and Emulsions n° II, respectively.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
J. G. Riess, Fluorocarbon-based blood substitutes, Artif. Org. 14: 255 (1991).
J. G. Riess, Hemocompatible fluorocarbon emulsions, in: “Blood Compatible Materials and Devices” C. P. Sharma, M. Szycher, eds., Technomics Publ. C°, Lancaster, Pa USA (1990), Chap. 14, 237.
K. C. Lowe, Synthetic oxygen transport fluids based on perfluorochemicals: Applications in medicine and biology, Vox Sang, 60: 129 (1991).
J. G. Riess, Fluorocarbon-based in vivo oxygen transport and delivery systems, Vox Sang. 60, X XX.
J. G. Riess, Reassessment of criteria for the selection of perfluorochemicals for second-generation blood substitutes: Analysis of structure/property relationships, Artif. Org. 8: 44 (1984).
R., Mitten, A. R. Burgan, A. Hamblin, G. Yee, D. C. Long, D. M. Long and R. F. Mattrey, Dose related biodistribution & elimination of 100% PFOB emulsion, in: “Blood Substitutes”, T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 671.
J. G. Riess, C. Arlen, J. Greiner, M. Le Blanc, A. Manfredi, S. Pace and C. Varescon, Design, synthesis and evaluation of fluorocarbons and surfactants for in vivo applications. New perfluoroalkylated polyhydroxylated surfactants, in: “Blood Substitutes”, T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 421.
D. Long, D. M. Long, J. G. Riess, R. Follana, A. Burgan and R. Mattrey, Preparation and application of highly concentrated perfluoroctylbromide fluorocarbon emulsions, in: “Blood Substitutes”, T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 441.
J G. Riess, J. L. Dalfors, G. K. Hanna, D. H. Klein, M-P. Krafft, T. J. Pelura and E. G. Schutt, Development of highly fluid, concentrated and stable fluorocarbon emulsions for diagnosis and therapy, Proceed. Intl. Svmp. Blood Substitutes,
R. Follana, D. Klein, M.-P. Krafft, D. M. Long, C. D. Long, J. G. Riess and A. Valla, Prolonged shelf life and biocompatibility of a concentrated injectable fluorocarbon emulsion, Proceed. Intl. Svmp. Blood Substitutes., Montreal, 1991.
M.-P. Krafft, J.-P. Rolland and J. G. Riess, Detrimental effect of excess lecithin on the stability of fluorocarbon/lecithin emulsions, J. Phys. Chem. 95:xxxx (1991).
G. Riess and M. Postel, Stability and stabilization of fluorocarbon emulsions, Proceed. Intl. Svmp. Blood Substitutes. Montreal, 1991.
M.-P. Krafft, J. P. Rolland and J. G. Riess, unpublished results.
M.-P. Krafft, F. Giulieri and J. G. Riess, unpublished results.
J. L. Dalfors, Terminal sterilization of perfluorocarbon emulsions: Difficulties and possible solutions, Proceed. Intl. Svmp. Blood Substitutes, Montreal 1991.
G. K. Hanna, M. C. Ojeda and T. A. Sklenar, Application of computer-based experimental design to optimization of processing conditions for perfluorocarbon emulsion, Proceed. Intl. Symp. Blood Substitutes, Montreal, 1991.
R. Naito and K. Yokoyama, Perfluorochemical blood substitutes, FC-43 emulsion Fluosol-DA, 20% and 35%, Technical Information Ser. n°s 5 and 7 (The Green Cross Corp., Osaka, Japan ( 1978, 1981 ).
F. F. Beloyartsev, E. I. Mayevsky and B. I. Islamov, Ftorosan-oxygen carrying perfluorochemical plasma substitute, Acad. Sci. USSR, Pushchino (1983).
H.-S. Chen, Z.-H. Yang et al, Perfluorocarbon as blood substitute in clinical applications and in war casualties, in: “Blood Substitutes”. T. M. S. Chang, R. P. Geyer, eds, Marcel Dekker, New York (1989), p. 403.
H. Ohyanagi, Y. Saitoh, T. Mitsuno, M. Watanabe, K. Yamanouchi and K. Yokoyama, A new perfluorochemical emulsion: An overview, Intl. J. Artif. Org. 14: 199 (1990).
R. E. Moore, Physical properties of a new synthetic oxygen carrier, Biomat., Art. Cells. Art. Org. 16: 443 (1988).
Therox, Fluorochemical Oxygen Carriers, DuPont, presentation brochure
R. J. Kaufman, Fluorocarbon emulsions as blood substitutes, Workshop on Emulsions. Bergen, Norway, June 1991.
J. G. Riess, Fluorocarbon-based oxygen carriers: New orientations. Artif. Org. 14:xxx (1991).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Riess, J.G., Krafft, MP. (1992). Elaboration of Fluorocarbon Emulsions with Improved Oxygen-Carrying Capabilities. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_52
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3428-0_52
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6516-7
Online ISBN: 978-1-4615-3428-0
eBook Packages: Springer Book Archive