Abstract
Massive aspiration of gastric contents is one of the most feared complications of general anesthesia and is known to be an important cause of the adult respiratory distress syndrome (ARDS) (for review, see Gibbs and Modell, 1990 and Fowler et al., 1983). Due to direct damage of the alveolar-capillary membrane, especially to the type I and II pneumocytes, protein-rich edema fluid enters the alveolar space (Awe et al., 1966; Greenfield et al., 1969; Grimbert et al., 1981; Kobayashi et al., 1990; Manny et al., 1986). It has been established that these plasma derived proteins are potent surfactant inhibitors (Ennema et al., 1988; Fuchimukai et al., 1987; Holm et al., 1988; Ikegami et al., 1984; Seeger et al., 1985). Besides this, it has been proposed that hydrochloric acid (HC1) directly damages the surfactant system (Greenfield et al., 1969; Winn et al., 1983). As the surfactant system seems to be involved in the pathophysiology of respiratory failure caused by HC1 aspiration, a study was designed to investigate the effect of different treatment strategies with an exogenous surfactant preparation on lung function of rats suffering from respiratory failure after intratracheal HC1 instillation.
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Eijking, E.P., Gommers, D., Kullander, J., de Buijzer, E., Beukenholdt, R.W., Lachmann, B. (1992). Different Surfactant Treatment Strategies for Respiratory Failure Induced by Hydrochloric Acid Aspiration in Rats. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_38
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DOI: https://doi.org/10.1007/978-1-4615-3428-0_38
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