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Blood Flow and Tissue Oxygenation of Human Tumors: An Update

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Oxygen Transport to Tissue XIV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 317))

Abstract

It is generally accepted that tumor microcirculation, blood flow, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status (factors which are usually closely linked and which define the so-called cellular microenvironment) can markedly influence the therapeutic response of malignant tumors. Tumor blood flow is the major determinant for intra-tumor pharmacokinetics and (through modulation of the cellular microenvironment) of pharmacody-namics. The oxygen supply greatly determines the radiosensitivity of the tumors to be treated. The oxygen enhancement ratio, i.e., the ratio of doses with and without oxygen to produce the same biological effect is 2.7 to 3.0. O2 partial pressures (O2 tensions) of 3 to 4 mmHg (i.e., 0.5 to 0.6% O2) result in a sensitivity halfway between radiobiological hypoxia and full oxygenation (Vaupel, 1992).

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Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, University of Mainz, D-6500, Mainz, Germany

    P. Vaupel & K. Schlenger

  2. Department of Obstetrics and Gynecology, University of Mainz, D-6500, Mainz, Germany

    M. Hoeckel

Authors
  1. P. Vaupel
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  2. K. Schlenger
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  3. M. Hoeckel
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Editors and Affiliations

  1. Erasmus University, Rotterdam, The Netherlands

    Wilhelm Erdmann

  2. University of Maryland Baltimore County, Baltimore, Maryland, USA

    Duane F. Bruley

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© 1992 Springer Science+Business Media New York

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Vaupel, P., Schlenger, K., Hoeckel, M. (1992). Blood Flow and Tissue Oxygenation of Human Tumors: An Update. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3428-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6516-7

  • Online ISBN: 978-1-4615-3428-0

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