Abstract
Application of hyperbaric oxygen, either in form of sessions with mild hyperoxia (1–2.5 ATA ≈ 100–250 kPa) or under pressures (up to 4–6.8 ATA) is used for different causes (enhancing cancer radiosensitivity, treatment of anaerobic infections, decompression sickness, consequences of cerebral ischemia a.o.). However, the danger of an increase of oxygen free radicals is given, whereas somatic adaptations will also occur.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Yam J, Frank L, Roberts RJ (1978) Oxygen toxicity: comparison of lung biochemical response in neonatal and adult rats. Pediat Res 12, 115–119
Yam J, Roberts RJ (1979) Pharmacological alteration of oxygen-induced lung toxicity. Toxicol Appl Pharmacol 47, 367–375
Kimball RE, Reddy K, Peirce TH, Schwartz LW, Mustafa MG, Cross CE (1976) Oxygen toxicity: augmentation of antioxidant defence mechanisms in rat lung. Am J Physiol 230, 1425–1431
Crouch LS, Prough RA, Kennedy KA, Snyder JB, Warshaw JB (1988) Rat lung antioxidant enzyme activities and their specific proteins during hyperoxia. J Appl Physiol 65, 797–804
Fridovich I, Freeman B (1986) Antioxidant defences in the lung. Ann Rev Physiol 48, 693–702
Jamieson D, Chance B, Cadenas E, Boveris A (1986) The relation of free radical production to hyperoxia. Ann Rev Physiol 48, 703–719
Smith LJ, Anderson J, Hamsuddin M, Hsueh W (1990) Effect of fasting on hyperoxic lung injury in mice. Am Rev Respir Dis 141, 141–149
Lutz J, Stark M (1988) Administration of perfluorochemicals under hyperbaric oxygen pressure and treatment with free oxygen radical scavengers. Biomat Art Cells Art Org 16, 395–402
Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106, 207–212
Deneke SM, Fanburg BL (1989) Regulation of cellular glutathione. Am J Physiol 257, L163 - L173
Sies H, Cadenas E (1983) Biological basis of detoxication of oxygen free radicals. In: Caldwell J, Jakoby WB (eds.) Biological Basis of Detoxication. Academic Press, New York, 181–211
Ziegler DM (1985) The role of reversible oxidation-reduction of enzyme thiol-disul-fide in metabolic regulation. Ann Rev Biochem 54, 305–329
Nishiki K, Jamieson D, Chance B (1976) Oxygen toxicity in the perfused rat liver and lung under hyperbaric conditions. Biochm J 160, 343–355
Deneke SM, Gershoff SN, Fanburg BL (1983) Potentiation of oxygen toxicity in rats by dietary protein or amino acid deficiency. J Appl Physiol 4, 147–151
Crapo JD (1986) Morphologic changes in pulmonary oxygen toxicity. Ann Rev Physiol 48, 721–731
Moorehouse PC, Grootveld M, Halliwell JG, Quinlan G, Gutteridge JMC (1987) Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Lett 213, 23–28
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Purucker, E., Lutz, J. (1992). Effect of Hyperbaric Oxygen Treatment and Perfluorochemical Administration on Glutathione Status of the Lung. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_13
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3428-0_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6516-7
Online ISBN: 978-1-4615-3428-0
eBook Packages: Springer Book Archive