Abstract
Studies comparing the negative inotropic effect of calcium antagonists and “related” receptor-affinities showed inconsistent results. We tested the possible relationship between the potency in inhibiting CaCl2-induced positive inotropy and receptor affinity. Therefore, we determined the relative potency of Nifedipine, Verapamil, Fendiline, Bepridil and Diltiazem both in isolated rabbit papillary muscle against CaCl2-induced positive inotropy (pA2) and their relative affinity (-log KD) in receptor binding experiments in rat cardiac homogenates.
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References
D. R. Ferry, and H. Glossmann, FEBS Lett. 148:331 (1982).
M. N. Garcia, M. I. Turmble, J. P. Reuben, G. I. Kaczorowski, J. Biol. Chem. 259:15013 (1984).
J. Batke, and J. Gaál, J. Biochem. Biophys. Meth. 12:203 (1986).
Y. W. Kwon, G. Franckowiak, D. A. Langs, M. Hawthorn, A. Joslyn, and D. J. Triggle, Naunyn-Schmiedeberg’ s Arch. Pharm. 339:19 (1989).
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© 1992 Springer Science+Business Media New York
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Fejér, E., Szeredi, J., Gaál, J., Körmöczy, P.S. (1992). Correlation Between the Results of Functional and Receptor Binding Studies in Cardiac Muscle. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_49
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_49
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