Abstract
Skeletal muscle contraction is initiated by the increase in the intracellular calcium concentration ([Ca2+]) following the depolarization of the surface- and transverse-(T-) tubular membranes (see the review by Ebashi, 1991). Calcium ions are released into the myoplasm from an intracellular store, the sarcoplasmic reticulum (SR), through the ryanodine receptor calcium release channel (Imagawa et al., 1987; Inui et al., 1987). The voltage sensitive step that links channel opening to depolarization is the displacement of permanent charges (charge movement, Schneider and Chandler, 1973) found in the T-tubular membrane and localized in the DHP receptor (Ríos and Pizarro, 1991).
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Csernoch, L., Pizarro, G., García, J., Szücs, G., Stefani, E., Ríos, E. (1992). Effects of Calcium Release from the Sarcoplasmic Reticulum on Intramembrane Charge Movement in Skeletal Muscle. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_10
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_10
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