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Topoisomerase II Inhibitors: Prospects for New Antifungal Agents

  • Chapter
Emerging Targets in Antibacterial and Antifungal Chemotherapy

Abstract

The DNA of both prokaryotic and eukaryotic cells exhibits several common tertiary structures including supercoils, knots, and catenanes, each of which is involved in various cellular processes (101, 80, 99). These topological forms of DNA may arise as a result of it being in a closed, circular form (rings or loops) such as in plasmid, viral, phage, or bacterial genomic DNA. Alternatively, the genomic DNA of eukaryotes may be complexed with proteins and other cellular molecules, at two points or more, in such a way that the ends are restricted and not free to rotate. Such constrained DNA domains (80, 103) pose certain topological problems that must be resolved by the cellular apparatus for successful propagation of the genetic material. This is achieved in both prokaryotic and eukaryotic organisms by a family of enzymes referred to as DNA topoisomerases. The enzymes are subdivided into type I and type II based on their ability to catalyse single- or double-strand cleavages, respectively; in addition type II enzymes have an energy requirement satisfied by ATP. In bacteria, topoisomerase II is often referred to as bacterial gyrase. E. coli contains two type I topoisomerases, the TopA and TopB proteins (84, 87).

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References

  1. Adachi, T., M. Mizuuchi, E.A. Robinson, E. Appella, M.H. O’Dea, M. Gellert, and K. Mizuuchi. 1987. DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res. 15:771–784.

    Article  PubMed  CAS  Google Scholar 

  2. Badaracco, G., P. Plevani, W.T. Ruyechan, and L.M.S. Chang. 1983. Purification and characterization of yeast topoisomerase I.J. Biol. Chem. 258:2022–2026.

    PubMed  CAS  Google Scholar 

  3. Barrett, J.F., J.A. Sutcliffe, and T.D. Gootz. 1990. In vitro assays used to measure the activity of topoisomerases. Antimicrob. Agents Chemother. 34:1–7.

    Article  PubMed  CAS  Google Scholar 

  4. Benson, J.D., and E.S. Huang. 1988. Two specific topoisomerase II inhibitors prevent replication of human cytomegalovirus DNA: an implied role in replication of the viral genome. J. Virology 62:4797–4800.

    PubMed  CAS  Google Scholar 

  5. Berrios, M., N. Osheroff, and P.A. Fisher. 1985. In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila melanogaster nuclear matrix fraction. Proc. Natl. Acad. Sci. USA 82:4142–4146.

    Article  PubMed  CAS  Google Scholar 

  6. Besterman, J.M., L.P. Elwell, S.G. Blanchard, and M. Cory. 1986. Amiloride intercalates into DNA and inhibits DNA topoisomerase II. J. Biol. Chem. 262:13352–13358.

    Google Scholar 

  7. Besterman, J.M., L.P. Elwell, E.J. Cragoe Jr., C.W. Andrews, and M. Corey. 1989. DNA intercalation and inhibition of topoisomerase II. Structure-activity relationships for a series of amiloride analogs. J. Biol. Chem. 265:2324–2330.

    Google Scholar 

  8. Bodley, A.L., and L.F. Liu. 1988. Topoisomerases as novel targets for cancer chemotherapy. Bio/Technology 1315–1319.

    Google Scholar 

  9. Boritzki, T.J., T.S. Wolfard, J.A. Besserer, R.C. Jackson, and D.W. Fry. 1988. Inhibition of type II topoisomerase by fostriecin. Biochem. Pharmacol. 37:4063–4068.

    Article  PubMed  CAS  Google Scholar 

  10. Brill, S.J., S. DiNardo, K. Voelkel-Meiman, and R. Sternglanz. 1987. Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature 326:414–416.

    Article  PubMed  CAS  Google Scholar 

  11. Caceres, J.F., D. Blangy, and G.C. Glikin. 1989. Requirement of DNA topoisomerases for in vitro chromatin assembly by 3T6 mouse cell extracts. Eur. J. Biochem. 181:531–537.

    Article  PubMed  CAS  Google Scholar 

  12. Carbonera, D., R. Cella, A. Montecucco, and G. Ciarrocchi. 1988. Isolation of a type I topoisomerase from carrot cells. J. Experiment. Bot. 39:70–78.

    Article  CAS  Google Scholar 

  13. Chakraborty, A.K., and H.K. Majumder. 1988. Mode of action of pentavalant antimonials: Specific inhibition of type I DNA topoisomerase of Leishmania donovani. Biochem. Biophys. Res. Commun. 152:605–611.

    Article  PubMed  CAS  Google Scholar 

  14. Champoux, J.J., and R. Dulbecco. 1972. An activity from mammalian cells that untwists superhelical DNA-a possible swivel for DNA replication. Proc. Natl. Acad. Sci. USA 69:143–146.

    Article  PubMed  CAS  Google Scholar 

  15. Chu, D.T.W., and P.B. Fernandes. 1989. Structure-activity relationships of the fluoroquinolones. Antimicrob. Agents Chemother. 33:131–135.

    Article  PubMed  CAS  Google Scholar 

  16. D’Arpa, P., P.S. Machlin, H. Ratrie III, N.F. Rothfield, D.W. Cleveland, and W.C. Earnshaw. 1988. cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc. Natl. Acad. Sci. USA 85:2543–2547.

    Article  PubMed  Google Scholar 

  17. Dewick, P.M., and D.E. Jackson. 1981. Cytotoxic lignans from Podophyllum , and the nomenclature of aryltetralin lignans. Phytochemistry 20:2277–2280.

    Article  CAS  Google Scholar 

  18. DiGate, R.J., and K.J. Marians. 1988. Identification of a potent decatenating enzyme from Escherichia coll. J. Biol. Chem. 263:13366–13373.

    PubMed  CAS  Google Scholar 

  19. DiGate, R.J., and K.J. Marians. 1989. Molecular cloning and DNA sequence analysis of Escherichia coli topB , the gene encoding topoisomerase III. J. Biol. Chem. 264:17924–17930.

    PubMed  CAS  Google Scholar 

  20. Downes, C.S., and R.T. Johnson. 1988. DNA topoisomerases and DNA repair. BioEssays 8:179–184.

    Article  PubMed  CAS  Google Scholar 

  21. Drake F.H., G.A. Hofmann, S.-M. Mong, J. Bartus, R.P. Hertzberg, R.K. Johnson, M.R. Mattern, and C.K. Mirabelli. 1989. In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res. 49:2578–2583.

    PubMed  CAS  Google Scholar 

  22. Drlica, K., and R.J. Franco. 1988. Inhibitors of DNA topoisomerases. Biochemistry 27:2253–2259.

    Article  PubMed  CAS  Google Scholar 

  23. Durban, E., M. Bramucci, and R. Cook. 1988. Partial amino acid sequence of rat topoisomerase I: comparison with the predicted sequences for the human and yeast enzymes. Biochem. Biophys. Res. Commun. 154:358–364.

    Article  PubMed  CAS  Google Scholar 

  24. Fairman, R., and D.L. Brutlag. 1988. Expression of the Drosophila Type II topoisomerase is developmentally regulated. Biochemistry 27:560–565.

    Article  PubMed  CAS  Google Scholar 

  25. Figgitt, D.P., S.P. Denyer, P.M. Dewick, D.E. Jackson, and P. Williams. 1989. Topoisomerase II: A potential target for novel antifungal agents. Biochem. Biophys. Res. Commun. 160:257–262.

    Article  PubMed  CAS  Google Scholar 

  26. Figgitt, D.P., A.J. Caston, S.P. Denyer, P. Williams, D.E. Jackson, C. Washington, and N. Stevenson. 1988. Disruption of microbial cells using a laboratory microfluidiser. J. Pharm. Phatmacol. 40(Suppl.):138P.

    Google Scholar 

  27. Fox, G.E., E. Stackebrandt, R.B. Hespell, J. Gibson, J. Maniloff, T.A. Dyer, R.S. Wolfe, W.E. Balch, R.S. Tanner, L.J. Magrum, L.B. Zablen, R. Blackmore, R. Gupta, L. Bonen, B.J. Lewis, D.A. Stahl, K.R. Luehrsen, K.N. Chen, and C.R. Woese. 1980. The phylogeny of prokaryotes. Science 209:457–465.

    Article  PubMed  CAS  Google Scholar 

  28. Gellert, M. 1981. DNA topoisomerases. Annu. Rev. Biochem. 50:879–910.

    Article  PubMed  CAS  Google Scholar 

  29. Gellert, M., K. Mizuuchi, M.H. O’Dea, and H.A. Nash. 1976. DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc. Natl. Acad. Sci. USA 73:3872–3876.

    Article  PubMed  CAS  Google Scholar 

  30. Gellert, M., M.H. O’Dea, T. Itoh, and J.-I. Tomizawa. 1976. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc. Natl. Acad. Sci. USA 73:4474–4478.

    Article  PubMed  CAS  Google Scholar 

  31. Gomi, S., M. Sezaki, S. Kondo, T. Hara, H. Naganawa, and T. Takeuchi. 1988. The structure of new antifungal antibiotics, benanomicins A and B. J. Antibiotics 42:1019–1028.

    Article  Google Scholar 

  32. Gomi, S., M. Sezaki, M. Hamada, S. Kondo, and T. Takeuchi. 1989. Biosynthesis of benanomicins. J. Antibiotics 42:1145–1150.

    Article  CAS  Google Scholar 

  33. Gootz, T.D., J.F. Barrett, and J.A. Sutcliffe. 1990. Inhibitory effects of quinolone antibacterial agents on eukaryotic topoisomerases and related test systems. Antimicrob. Agents Chemother. 34:8–12.

    Article  PubMed  CAS  Google Scholar 

  34. Goto, T., P. Laipis, and J.C. Wang. 1984. The purification and characterization of DNA topoisomerases I and II of the yeast Saccharomyces cerevisiae. J. Biol. Chem. 259:10422–10429.

    PubMed  CAS  Google Scholar 

  35. Goto, T., and J.C. Wang. 1982. Yeast DNA topoisomerase II. J. Biol. Chem. 257:5866–5872.

    PubMed  CAS  Google Scholar 

  36. Goto, T., and J.C. Wang. 1984. Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Cell 36:1073–1080.

    Article  PubMed  CAS  Google Scholar 

  37. Goto, T., and J.C. Wang. 1985. Cloning of yeast TOP] , the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc. Natl. Acad. Sci. USA 82:7178–7182.

    Article  PubMed  CAS  Google Scholar 

  38. Hamelin, C., J. Yelle, and M. Dion. 1986. Fast electrophoresis in superposed agarose minigels for DNA topoisomerase assays. Electrophoresis 7:323–326.

    Article  CAS  Google Scholar 

  39. Heck, M.M.S., W.M. Hittelman, and W.C. Earnshaw. 1988. Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle. Proc. Natl. Acad. Sci. USA 85:1086–1090.

    Article  PubMed  CAS  Google Scholar 

  40. Hertzberg, R.P., M.J. Caranfa, and S.M. Hecht. 1989. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex. Biochemistry 28:4629–4638.

    Article  PubMed  CAS  Google Scholar 

  41. Holm, C., J.M. Covey, D. Kerrigan, and Y. Pommier. 1989. Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in chinese hamster DC3F cells. Cancer Res. 49:6365–6368.

    PubMed  CAS  Google Scholar 

  42. Hong, J.H., K. Okada, T. Kusano, Y. Komazawa, M. Kobayashi, A. Mizutani, N. Kamada, and A. Kuramoto. 1990. Reduced DNA topoisomerase II in VP-16 resistant mouse breast cancer cell line. Biomed. Pharmacother. 44:41–46.

    Article  PubMed  CAS  Google Scholar 

  43. Hsieh, T., and D. Brutlag. 1980. ATP-Dependent DNA topoisomerase fromDrosophila melanogaster reversibly catenates duplex DNA rings. Cell 21:115–125.

    Article  PubMed  CAS  Google Scholar 

  44. Huang, W.M., S.-Z. Ao, S. Casjens, R. Orlandi, R. Zeikus, R. Weiss, D. Winge, and M. Fang. 1988. A persistent untranslated sequence within bacteriophage T4 DNA topoisomerase gene 60. Science 239:1005–1012.

    Article  PubMed  CAS  Google Scholar 

  45. Ikegami, Y., N. Takeuchi, M. Hanada, Y. Hasegawa, K. Ishii, T. Andoh, T. Sato, K. Suzuki, H. Yamaguchi, S. Miyazaki, K. Nagai, S.-I. Watanabe, and T. Saito. 1990. Topostin, a novel inhibitor of mammalian DNA topoisomerase I from Flexi bacter topostinus sp. Nov. J. Antibiotics 43:158–162.

    Article  CAS  Google Scholar 

  46. Jackson, D.E., and P.M. Dewick. 1984. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry 23:1147–1152.

    Article  CAS  Google Scholar 

  47. Jackson, D.E., and P.M. Dewick. 1984. Biosynthesis of Podophyllum lignans-II. Interconversions of aryltetralin lignans in Podophyllum hexandrum. Phytochemistry 23:1037–1042.

    Article  CAS  Google Scholar 

  48. Juan, C.-C., J. Hwang, A.A. Liu, J. Whang-Peng, T. Knutsen, K. Huebner, C.M. Croce, H. Zhang, J.C. Wang, and L.F. Liu. 1988. Human DNA topoisomerase Lis encoded by a single-copy gene that maps to chromosome region 20812–13.2. Proc. Nat!. Acad. Sci. USA 85:8910–8913.

    Article  PubMed  CAS  Google Scholar 

  49. Juang, J.-K., H.W. Huang, C.-M. Chen, and H.J. Liu. 1989. A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage. Biochem. Biophys. Res. Commun. 159:1128–1134.

    Article  PubMed  CAS  Google Scholar 

  50. Keller, W. 1975. Characterisation of purified DNA-relaxing enzyme from human tissue culture cells. Proc. Nat!. Acad. Sci. USA 72:2550–2554.

    Article  PubMed  CAS  Google Scholar 

  51. Kievan, L., and J.C. Wang. 1980. Deoxyribonucleic acid gyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an azß2 protein core. Biochemistry 19:5229–5234.

    Article  Google Scholar 

  52. Kono, H., N. Habuka, and K. Shishido. 1986. Purification and characterization of type I DNA topoisomerase from Lentinus edodes. FEMS Microbiol. Lett. 37:169–172.

    Article  CAS  Google Scholar 

  53. Kreuzer, K.N. 1989. DNA topoisomerases as potential targets of antiviral action. Pharmac. Ther. 43:377–395.

    Article  CAS  Google Scholar 

  54. Latham, M.D., C.K. King, P. Gorycki, T.L. Macdonald, and W.E. Ross. 1989. Inhibition of topoisomerases by fredericamycin A. Cancer Chemother. Pharmacol. 24:167–171.

    Article  PubMed  CAS  Google Scholar 

  55. Lazarus, G.M., J.P. Henrich, W.G. Kelly, S.A. Schmitz, and F.J. Castora. 1987. Purification and characterization of a type I DNA topoisomerase from calf thymus mitochondria. Biochemistry 26:6195–6203.

    Article  PubMed  CAS  Google Scholar 

  56. Liu, L.F. 1989. DNA topoisomerase poisons as antitumour drugs. Annu. Rev. Biochem. 58:351–375.

    Article  PubMed  CAS  Google Scholar 

  57. Liu, L.F., and K. Miller. 1981. Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei. Proc. Natl. Acad. Sci. USA 78:3487–3491

    Article  PubMed  CAS  Google Scholar 

  58. Liu, L.F., C.-C. Liu, and B.M. Alberts. 1979. T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature 281:456–461.

    Article  PubMed  CAS  Google Scholar 

  59. Liu, L.F., and J.C. Wang. 1978. Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc. Natl. Acad. Sci. USA 75:2098–2102.

    Article  PubMed  CAS  Google Scholar 

  60. McHugh, M.M., J.M. Woynarowski, R.D. Sigmund, and T.A. Beerman. 1989. Effect of minor groove binding drugs on mammalian topoisomerase I activity. Biochem. Pharmacol. 38:2323–2328.

    Article  PubMed  CAS  Google Scholar 

  61. Miller, K.G., L.F. Liu, and P.T. Englund. 1981. A homogenous type II topoisomerase from HeLa cell nuclei. J. Biol. Chem. 256:9334–9339.

    PubMed  CAS  Google Scholar 

  62. Moriya, S., N. Ogasawara, and H. Yoshikawa. 1985. Structure and function of the region of the replication origin of the Bacillus subtilis chromosome. III. Nucleotide sequence of some 10,000 base pairs in the origin region. Nucleic Acids Res. 13:2251–2265.

    Article  PubMed  CAS  Google Scholar 

  63. Nielsen, B.L., and K.K. Tewari. 1988. Pea chloroplast topoisomerase I: purification, characterization, and role in replication. Plant Mol. Biol. 11:3–14.

    Article  CAS  Google Scholar 

  64. Nitiss, J., and J.C. Wang. 1988. DNA topoisomerase-targeting antitumour drugs can be studied in yeast. Proc. Natl. Acad. Sci. USA 85:7501–7505.

    Article  PubMed  CAS  Google Scholar 

  65. Oki, T., O. Tenmyo, M. Hirano, K. Tomatsu, and H. Kamei. 1990. Pradimicins A, B and C: New antifungal antibiotics. II. In vitro and in vivo biological activities. J. Antibiotics 43:763–770.

    Google Scholar 

  66. Okura, A., H. Arakawa, H. Ok, T. Yoshinari, and Y. Monden. 1988. Effect of genistein on topoisomerase activity and on the growth of [VAL 12] Ha-ras-transformed NIH 3T3 cells. Biochem. Biophys. Res. Commun. 157:183–189.

    Article  PubMed  CAS  Google Scholar 

  67. Osheroff, N. 1989. Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide. Biochem. 28:6157–6160.

    Article  CAS  Google Scholar 

  68. Pommier, Y., M.R. Mattem, R.E. Schwartz, L.A. Zwelling, and K.W. Kohn. 1984. Changes in deoxyribonucleic acid linking number due to treatment of mammalian cells with the intercalating agent 4’-(9-acridinylamino)methanesulfon-m-anisidide. Biochemistry 23:2927–2932.

    Article  PubMed  CAS  Google Scholar 

  69. Pyke, K.A., J. Marrison, and R.M. Leach. 1989. Evidence for a type II topoisomerase in wheat chloroplasts. FEBS Lett. 242:305–308.

    Article  CAS  Google Scholar 

  70. Richard, R.E., and D.F. Bogenhagen. 1989. A high molecular weight topoisomerase I from Xenopus laevis ovaries. J. Biol. Chem. 264:4704–4709.

    PubMed  CAS  Google Scholar 

  71. Riou, G.F., M. Gabillot, S. Douc-Rasy, A. Kayser, and M. Barrois. 1983. A. type I DNA topoisomerase from Trypanosoma cruzi. Eur. J. Biochem. 134:479–484.

    Article  PubMed  CAS  Google Scholar 

  72. Riou, J.-F., M. Gabillot, M. Philippe, J. Schrevel, and G. Riou. 1986. Purification and characterisation of Plasmodium berghei DNA topoisomerases I and II: drug action, inhibition of decatenation and relaxation, and stimulation of DNA cleavage. Biochemistry 25:1471–1479.

    Article  PubMed  CAS  Google Scholar 

  73. Robinson, M.J., and N. Osheroff. 1990. Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4’-(9-acridinylamino)methanesulfon-m-anisidide. Biochem. 29:2511–2515.

    Article  CAS  Google Scholar 

  74. Rose, K.M. 1988. DNA topoisomerases as targets for chemotherapy. FASEB J. 2:2474–2478.

    PubMed  CAS  Google Scholar 

  75. Rowe, T.C., J.R. Rusche, M.J. Brougham, and W.K. Holloman. 1981. Purification and properties of a topoisomerase from Ustilago maydis. J. Biol. Chem. 256:10354–10361.

    PubMed  CAS  Google Scholar 

  76. Russo, P., M. Peluso, S. Parodi, S. Tornalet, A.M. Pedrini, F. Palitti, and B.A. Kihlman. 1986. DNA-topoisomerase II in mammalian cells could be a target of caffeine (C) and 8-methoxycaffeine (8MC). Eur. J. Cell Biol. 42:6a.

    Google Scholar 

  77. Sander, M., and T.-S. Hsieh. 1983. Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster. J. Biol. Chem. 258:8421–8428.

    PubMed  CAS  Google Scholar 

  78. Sawada, Y., M. Nishio, H. Yamamoto, M. Hatori, T. Miyaki, M. Konishi, and T. Oki. 1990. New antifungal antibiotics, pradimicins D and E. Glycine analogs of pradimicins A and C. J. Antibiotics 43:771–777.

    Article  CAS  Google Scholar 

  79. Schomburg, V., and F. Grosse. 1986. Purification and characterisation of DNA topoisomerase II from calf thymus associated with polypeptides of 175 and 150 kDa. Eur. J. Biochem. 160:451–457.

    Article  PubMed  CAS  Google Scholar 

  80. Scovell, W.M. 1986. Supercoiled DNA. J. Chem. Educ. 63:562–565.

    Article  CAS  Google Scholar 

  81. Shuman, S., M. Golder, and B. Moss. 1989. Insertional mutagenesis of the vaccinia virus gene encoding a type I DNA topoisomerase: evidence that the gene is essential for virus growth. Virology 170:302–306.

    Article  PubMed  CAS  Google Scholar 

  82. Sioud, M., G. Baldacci, P. Forterre, and A.-M. de Recondo. 1987. Antitumor drugs inhibit the growth of halophilic archaebacteria. Eur. J. Biochem. 169:231–236.

    Article  PubMed  CAS  Google Scholar 

  83. Smith, P.J. 1990. DNA topoisomerase dysfunction a new goal for antitumour chemotherapy. BioEssays 12:167–172.

    Article  PubMed  CAS  Google Scholar 

  84. Srivenugopal, K.S., D. Lockshon, and D.R. Morris. 1984. Escherichia coli DNA topoisomerase III: purification and characterisation of a new type I enzyme. Biochemistry 23:1899–1906.

    Article  PubMed  CAS  Google Scholar 

  85. Sugino, A., and K.F. Bott. 1980. Bacillus subtilis deoxyribonucleic acid gyrase. J. Bacteriol. 141:1331–1339.

    PubMed  CAS  Google Scholar 

  86. Sugino, A., C.L. Peebles, K.N. Kreuzer, and N.R. Cozzarelli. 1977. Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme. Proc. Natl. Acad. Sci. USA 74:4767–4771.

    Article  PubMed  CAS  Google Scholar 

  87. Sutcliffe, J.A., T.D. Gootz, and J.F. Barrett. 1989. Biochemical characteristics and physiological significance of major DNA topoisomerases. Antimicrob. Agents Chemother. 33:2027–2033.

    Article  PubMed  CAS  Google Scholar 

  88. Suzuki, K., H. Yamaguchi, S. Miyazaki, K. Nagai, S.-I. Watanabe, T. Saito, K. Ishii, M. Hanada, T. Sekine, Y. Ikegami, and T. Andoh. 1990. Topostin, a novel inhibitor of mammalian DNA topoisomerase I from Flexibacter topostinus sp. Nov. J. Antibiotics 43:154–157.

    Article  CAS  Google Scholar 

  89. Takeuchi, T., T. Hara, N. Naganawa, M. Okada, M. Hamada, H. Umezawa, S. Gomi, M. Sezaki, and S. Kondo. 1988. New antifungal antibiotics, benanomicins A and B from an Actinomycete. J. Antibiotics 41:807–811.

    Article  CAS  Google Scholar 

  90. Tewey, K.M., G.L. Chen, E.M. Nelson, and L.F. Liu. 1984. Intercalative antitumor drugs interfere with the breakage-reunion reactions of mammalian DNA topoisomerase II. J. Biol. Chem. 259:9182–9187.

    PubMed  CAS  Google Scholar 

  91. Thrash, C., A.T. Bankier, B.G. Barrell, and R. Sternglanz. 1985. Cloning, characterization and sequence of the yeast DNA topoisomerase I gene. Proc. Natl. Acad. Sci. USA 82:4374–4378.

    Article  PubMed  CAS  Google Scholar 

  92. Thurston, L.S., H. Irie, and S. Tani. 1986. Antitunor agents. 78. Inhibition of human DNA topoisomerase II by podophyllotoxin and a-peltatin analogues. J. Med. Chem. 29:1547–1550.

    Article  PubMed  CAS  Google Scholar 

  93. Tomita, K., N. Nishio, K. Saitoh, H. Yamamoto, Y. Hoshino, H. Ohkuma, M. Konishi, T. Miyaki, and T. Oki. 1990. Pradimicins A, B and C: New antifungal antibiotics. I. Taxonomy, production, isolation and physico-chemical properties. J. Antibiotics 43:755–762.

    Article  CAS  Google Scholar 

  94. Trask, D.K., and M.T. Muller. 1983. Biochemical characterization of topoisomerase I purified from avian erythrocytes. Nucleic Acids Res. 11:2779–2800.

    Article  PubMed  CAS  Google Scholar 

  95. Tse-Ding, Y.-C., and J.C. Wang. 1986. Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I. J. Mol. Biol. 191:321–331.

    Article  Google Scholar 

  96. Uemura, T., K. Morikawa, and M. Yanagida. 1986. The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases. EMBO J. 5:2355–2361.

    PubMed  CAS  Google Scholar 

  97. Uemura, T., K. Morino, S. Uzawa, K. Shiozaki, and M. Yanagida. 1987. Cloning and sequencing of Schizosaccharomyces pombe DNA topoisomerase I gene, and the effect of gene disruption. Nucleic Acids Res. 23:9727–9739.

    Article  Google Scholar 

  98. van Maanen, J.M.S., J. Retel, J. de Vries, and H.M. Pinedo. 1988. Mechanism of action of antitumour drug etoposide: A review. J. Nat. Cancer Inst. 80:1526–1533.

    Article  PubMed  Google Scholar 

  99. Wang, J.C. 1985. DNA topoisomerases. Annu. Rev. Biochem. 54:665–697.

    Article  CAS  Google Scholar 

  100. Wang. J.C. 1987. Recent studies of DNA topoisomerases. Biochim. Biophys. Acta. 909:1–9.

    Article  PubMed  Google Scholar 

  101. Wang, J.C. 1987. DNA topoisomerases: From a laboratory curiosity to a subject in cancer chemotherapy. NCI Monographs 4:3–6.

    PubMed  Google Scholar 

  102. Wang, Z.-Q., Y.-H. Kuo, D. Schnur, J.P. Bowen, S.-Y. Liu, F.-S. Han, J.-Y. Chang, Y.-C. Cheng, and K.-H. Lee. 1990. Antitumor agents 113. New 4/3arylan ino derivatives of 4’-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II. J. Med. Chem. 33:2660–2666.

    Article  PubMed  CAS  Google Scholar 

  103. Wasserman, S.A., and N.R. Cozzarelli. 1986. Biochemical topology: applications to DNA recombination and replication. Science 232:951–960.

    Article  PubMed  CAS  Google Scholar 

  104. Wolfson, J.S., and D.C. Hooper (eds.) 1989. Quinolone Antimicrobial Agents. ASM Washington.

    Google Scholar 

  105. Woynarowski, J.M., M. McHugh, R.D. Sigmund, and T.A. Beerman. 1988. Modulation of topoisomerase II catalytic activity by DNA minor groove binding agents distamycin, Hoechst 33258, and 4’,6-diamidine-2-phenylindole. Mol. Pharmacol. 35:177–182.

    Google Scholar 

  106. Wyckoff, W., and T.-S. Hsieh. 1988. Functional expression of a Drosophila gene in yeast: genetic complementation of DNA topoisomerase II. Proc. Natl. Acad. Sci. USA 85:6272–6276.

    Article  PubMed  CAS  Google Scholar 

  107. Wyckoff, E., D. Natalie, J.M. Nolan, M. Lee, and T.-S. Hsieh. 1989. Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerase II. J. Mol. Biol. 205:1–13.

    Article  PubMed  CAS  Google Scholar 

  108. Yamashita, Y., S.-Z. Kawada, N. Fujii, and H. Nakano. 1990. Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin. Cancer Res. 50:5841–5844.

    PubMed  CAS  Google Scholar 

  109. Zhang, H., P. D’Arpa, and L.F. Liu. 1990. A model for tumor cell killing by topoisomerase poisons. Cancer cells 2:23–27.

    PubMed  CAS  Google Scholar 

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Authors
  1. David E. Jackson
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  2. D. P. Figgitt
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  3. Stephen P. Denyer
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Editor information

Editors and Affiliations

  1. Department of Chemotherapy (58/2), Roche Research Center, Nutley, NJ, 07110-1199, USA

    Nafsika H. Georgopapadakou

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© 1992 Springer Science+Business Media Dordrecht

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Jackson, D.E., Figgitt, D.P., Denyer, S.P. (1992). Topoisomerase II Inhibitors: Prospects for New Antifungal Agents. In: Sutcliffe, J.A., Georgopapadakou, N.H. (eds) Emerging Targets in Antibacterial and Antifungal Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3274-3_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3274-3_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6440-5

  • Online ISBN: 978-1-4615-3274-3

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