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Historical Perspectives of Approaches to Antibiotics Discovery

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Emerging Targets in Antibacterial and Antifungal Chemotherapy

Abstract

The first 20 years in the half century of antibiotic search and discovery yielded many successful antibiotics. The chances of discovering new useful antibiotics, however, declined, sharply thereafter, precipitating strategic changes. Mechanism-based or target-directed screening, utilization of rare microorganisms and unusual culture conditions, and introduction of gene technology to modify antibiotic productivity have been among the major changes; these topics will be reviewed in this chapter.

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Authors
  1. Akira Imada
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  2. Kunimoto Hotta
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Editors and Affiliations

  1. Department of Chemotherapy (58/2), Roche Research Center, Nutley, NJ, 07110-1199, USA

    Nafsika H. Georgopapadakou

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© 1992 Springer Science+Business Media Dordrecht

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Imada, A., Hotta, K. (1992). Historical Perspectives of Approaches to Antibiotics Discovery. In: Sutcliffe, J.A., Georgopapadakou, N.H. (eds) Emerging Targets in Antibacterial and Antifungal Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3274-3_1

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  • DOI: https://doi.org/10.1007/978-1-4615-3274-3_1

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