Abstract
The carotid body located in the bifurcation of the carotid arteries is able to detect gas changes in blood composition (PO2, PCO2/pH) and to transduce them into afferent nerve signal. The intimate mechanism responsible for this chemoreceptive response to PO2 changes is not yet well understood. Various reports point to a chain of events initiated by disturbance of cell metabolism followed by transmitter release and depolarization of nerve endings (Mills and Jobsis, 1972; Hayashida et al., 1980). It seems, however, that glycolysis also plays an essential role in chemoreception, because lowering PO2 stimulates glycolysis in the cat carotid body in vitro (Delpiano and Acker, 1985). The aim of this article is to present evidence that this may not be the case as inhibition of glucose utilization by substrate deprivation or by uptake blocks almost totally glycolyticdependent pH decrease but only partially chemoreception.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Cheung, P. T., and Hammerman, M. R., 1988, Na+-independent D-glucose transport in rabbit renal basolateral membranes, Am. J. Physiol., 254:F711.
Delpiano, M. A., and Acker, H., 1985a, Extracellular pH changes in the superfused cat carotid body during hypoxia and hypercapnia, Brain Res., 342:273.
Delpiano, M. A., and Acker, H., 1985b, Extracellular pH responses to different stimuli in the superfused cat carotid body, Adv. Exp. Med. Biol., 191:709.
Delpiano, M. A., 1987, Glycolysis as a link for chemoreception?, in: “Chemoreceptors in Respiratory Control”, J. A. Ribeiro and D. J. Pallot, eds., Croom Helm, London.
Delpiano, M.A., and Acker, H., 1989, Hypoxic and hypercapnic responses of [Ca2+]o and [K+]o in the cat carotid body in vitro, Brain Res., 482:235.
Hayashida, Y., Koyano, H., and Eyzaguirre, C., 1980, An intracellular study of chemosensory fibers and endings, J. Neurophysiol., 44:1077.
Mills, E., and Jobsis, F. F., 1972, Mitochondrial respiration chain of carotid body and chemoreceptor response to changes in oxygen tension, J. Neurophysiol., 35:405.
Obeso, A., Almaraz, L., and Gonzalez, C., 1986, Effects of 2-deoxy-D-glucose on in vitro cat carotid body, Brain Res., 371:25.
Obeso, A., Gonzalez, C., Dinger, B., and Fidone, S, 1989, Metabolic activation of carotid body glomus cells by hypoxia, J. Appl. Physiol., 67:484.
Rumsey, W. L., Iturriaga, R., Spergel, D., Lahiri, S., and Wilson, D. F., 1992, Intracellular pH and chemoreception in the isolated perfused and superfused cat carotid body (this Symposium).
Spergel, D., 1992, Glutamate as a metabolic substrate in O2 chemoreception in the cat carotid body (this Symposium).
Toggenburger,G.,Kessler, M., and Semenza, G., 1982, Phlorizin as a probe of the small-intestinal Na+, D-glucose cotransporter, Biochim. Biophys. Acta, 688:557.
Webb, J. L., 1966, “Enzyme and Metabolic Inhibitors, Vol. III, Academic Press, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Delpiano, M.A. (1993). Evidence for Glucose Uptake in the Rabbit Carotid Body. In: Data, P.G., Acker, H., Lahiri, S. (eds) Neurobiology and Cell Physiology of Chemoreception. Advances in Experimental Medicine and Biology, vol 337. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2966-8_16
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2966-8_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6290-6
Online ISBN: 978-1-4615-2966-8
eBook Packages: Springer Book Archive