Abstract
Studies of model rat prostate tissue and derived cells indicate the insulin-like (IGF), epidermal growth factor (EGF), transforming growth factor beta (TGF-β) and heparin-binding fibroblast growth factor (HBGF) families and their receptors may play important roles in regulation of normal prostate cell growth. Tumor cells at different levels in the progression from slow-growing, hormone-dependence to fast-growing, hormone-independence exhibit distinct alterations in expression of specific growth factors and their receptor phenotype. Distinct IGF-I and HBGF mRNAs are constitutively expressed in the mesenchymal cells of slow-tumors, but alteration in HBGF receptor phenotype occurs in the epithelial cells. Fast-tumors exhibit even higher constitutive expression of multiple HBGFs. Splice variants in cDNA for the HBGF receptor in fast-tumors suggest constitutive expression of an intracellular receptor, that together with intracellular HBGFs, may constitute an intracellular autocrine system that is independent of exogenous hormones and growth factors.
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McKeehan, W.L., Adams, P.S., and Rosser, M.P., 1984, Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture, Cancer Res., 44:1998.
Chaproniere, D.M., and McKeehan, W.L., 1986, Serial culture of single adult human prostatic epithelial cells in serum-free medium containing lowcalcium and a new growth factor from bovine brain, Cancer Res., 46:819.
McKeehan, W.L., Adams, P.S., and Fast, D., 1987, Different hormonal requirements for androgen-independent growth of normal and tumor epithelial cells from rat prostate, In Vitro Cell. Devel. Biol., 23:147.
McKeehan, W.L., and Adams, P.S., 1988, Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor beta, In Vitro Cell. Devel. Biol, 24:243.
Murphy, L.J., Bell, G.I., Duckworth, M.L., and Friesen, H.G., 1987, Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I, Endocrinol., 121:684.
Burgess, W.H., and Maciag, T., 1989, The heparin-binding (fibroblast) growth factor family of proteins, Ann. Rev. Biochem, 58:575.
Story, M.T., Sasse, J., Jacobs, S.C., and Lawson, R.K., 1987, Prostatic growth factor: purification and structural relationship to basic fibroblast growth factor, Biochemistry, 26:3843.
Mansson, P.E., Adams, P., Kan, M., and McKeehan, W.L., 1989, Heparinbinding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors, Cancer Res., 49:2485.
Hou, J., Kan, M., McKeehan, K., McBride, G., Adams, P., and McKeehan, W.L., 1990, Fibroblast growth factor receptors from liver vary in three structural domains, Science (in press).
Hoshi, H., Kan, M., Mioh, H., Chen, J-K., and McKeehan, W.L., 1988, Phorbol ester-dependent reduction in receptor number correlates with attenuation of heparin-binding growth factor-dependent DNA synthesis in human adult large vessel endothelial cells, FASEB J., 2:2797.
Hou, J., Wang, F., McBride, G., McKeehan, K., Kan, M., and McKeehan, W.L., 1991, Different splice variations encoded in complementary DNA from a human hepatoma and a rat prostate tumor predict similar intracellular isoforms of the heparin-binding fibroblast growth factor receptor, (in preparation).
Wilson, E.M., and French, F.S., 1980, Biochemical homology between rat dorsal prostate and coagulating gland, J. Biol. Chem., 255:10946.
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© 1993 Springer Science+Business Media New York
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McKeehan, W.L., Hou, J., Adams, P., Wang, F., Yan, GC., Kan, M. (1993). Heparin-Binding Fibroblast Growth Factors and Prostate Cancer. In: Yang, S.S., Warner, H.R. (eds) The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging. Advances in Experimental Medicine and Biology, vol 330. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2926-2_15
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DOI: https://doi.org/10.1007/978-1-4615-2926-2_15
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