Skip to main content

Effects of Intralaryngeal CO2 And H+ on Laryngeal Receptor Activity in the Perfused Larynx in Cats

  • Chapter
Arterial Chemoreceptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 360))

Abstract

Intralaryngeal CO2 alters discharges of superior laryngeal nerve (SLN) afferent fibres (Boushey et al, 1974. Bradford et al, 1990) and reflexly enhances the activity of upper airway dilating muscles (Nolan et al, 1990, Bartlett et al, 1992a), decreases ventilation (Boushey et al, 1974, Nolan et al, 1990) and phrenic nerve activity (Bartlett et al, 1992a) These reflex effects are abolished by SLN section. The above results suggest that laryngeal CO2 receptors may play an important role in maintaining upper airway patency To elucidate mechanisms of CO2-induced effects on laryngeal mechanoreceptors, an in situ, isolated, perfused larynx has been developed Part of this study has been briefly reported elsewhere (O’Regan et al, 1993)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Anderson, J.W., Sant’Ambrogio, F.B., Orani, G.P., Sant’Ambrogio, G. &Mathew, O.P. (1990). Carbon dioxide-responsive laryngeal receptors in the dog. Respir. Physiol. 82:217–226.

    Article  PubMed  CAS  Google Scholar 

  • Bartlett, D.Jr., Knuth, S.L. &Gdovin, M.J. (1992a). Influences of intralaryngeal CO2 on respiratory activities of motor nerves to accessory muscles. Respir. Physiol. 90:289–297.

    Article  PubMed  Google Scholar 

  • Bartlett, D.Jr. &Knuth, S.L. (1992b). Responses of laryngeal receptors to intralaryngeal CO2 in the cat. J. Physiol. (Lond) 475:187–193.

    Google Scholar 

  • Black, A.M.S., McCloskey, D.I. &Torrance, R.W. (1971). The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli. Respir. Physiol. 13:36–49.

    Article  PubMed  CAS  Google Scholar 

  • Boushey, H.A., Richardson, P.S., Widdicombe, J.G. &Wise, J.C.M. (1974). The response of laryngeal afferent fibres to mechanical and chemical stimuli. J. Physiol. (Lond.) 240:153–175.

    CAS  Google Scholar 

  • Bradford, A., Nolan, P., McKeogh, D., Bannon, C. &O’Regan, R.G. (1990). The responses of superior laryngeal nerve afferent fibres to laryngeal airway CO2 concentration in the anaesthetized cat. Exp. Physiol.75:267–270.

    PubMed  CAS  Google Scholar 

  • Iturriaga, R., Lahiri, S. &Mokashi, A. (1991). Carbonic anhydrase and chemoreception in the cat carotid body. Am. J. Physiol. 261:C565–573.

    PubMed  CAS  Google Scholar 

  • Nolan, P., Bradford, A., O’Regan, R.G. &McKeogh, D. (1990). The effects of changes in laryngeal airway CO2 concentration on genioglossus muscle activity in the anaesthetized cat. Exp. Physiol. 75:271–274.

    PubMed  CAS  Google Scholar 

  • O’Regan, R.G., Wang, Z.H., Nolan, P. &Bradford, A. (1993). Airway PCO2 modifies laryngeal mechanoreceptors independent of the pH of the media perfusing the isolated larynx in the anaesthetised cat. Proc. XXXII IUPS Congress, Glasgow, 1993, 183.3/P.

    Google Scholar 

  • Wang, Z.H., O’Regan, R.G., &Giles, J.J. (1993). Histochemical demonstration of carbonic anhydrase in the larynx. This volume.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Wang, Z.H., Bradford, A., O’Regan, R.G. (1994). Effects of Intralaryngeal CO2 And H+ on Laryngeal Receptor Activity in the Perfused Larynx in Cats. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_71

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2572-1_71

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6099-5

  • Online ISBN: 978-1-4615-2572-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics