Abstract
Intralaryngeal CO2 alters discharges of superior laryngeal nerve (SLN) afferent fibres (Boushey et al, 1974. Bradford et al, 1990) and reflexly enhances the activity of upper airway dilating muscles (Nolan et al, 1990, Bartlett et al, 1992a), decreases ventilation (Boushey et al, 1974, Nolan et al, 1990) and phrenic nerve activity (Bartlett et al, 1992a) These reflex effects are abolished by SLN section. The above results suggest that laryngeal CO2 receptors may play an important role in maintaining upper airway patency To elucidate mechanisms of CO2-induced effects on laryngeal mechanoreceptors, an in situ, isolated, perfused larynx has been developed Part of this study has been briefly reported elsewhere (O’Regan et al, 1993)
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References
Anderson, J.W., Sant’Ambrogio, F.B., Orani, G.P., Sant’Ambrogio, G. &Mathew, O.P. (1990). Carbon dioxide-responsive laryngeal receptors in the dog. Respir. Physiol. 82:217–226.
Bartlett, D.Jr., Knuth, S.L. &Gdovin, M.J. (1992a). Influences of intralaryngeal CO2 on respiratory activities of motor nerves to accessory muscles. Respir. Physiol. 90:289–297.
Bartlett, D.Jr. &Knuth, S.L. (1992b). Responses of laryngeal receptors to intralaryngeal CO2 in the cat. J. Physiol. (Lond) 475:187–193.
Black, A.M.S., McCloskey, D.I. &Torrance, R.W. (1971). The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli. Respir. Physiol. 13:36–49.
Boushey, H.A., Richardson, P.S., Widdicombe, J.G. &Wise, J.C.M. (1974). The response of laryngeal afferent fibres to mechanical and chemical stimuli. J. Physiol. (Lond.) 240:153–175.
Bradford, A., Nolan, P., McKeogh, D., Bannon, C. &O’Regan, R.G. (1990). The responses of superior laryngeal nerve afferent fibres to laryngeal airway CO2 concentration in the anaesthetized cat. Exp. Physiol.75:267–270.
Iturriaga, R., Lahiri, S. &Mokashi, A. (1991). Carbonic anhydrase and chemoreception in the cat carotid body. Am. J. Physiol. 261:C565–573.
Nolan, P., Bradford, A., O’Regan, R.G. &McKeogh, D. (1990). The effects of changes in laryngeal airway CO2 concentration on genioglossus muscle activity in the anaesthetized cat. Exp. Physiol. 75:271–274.
O’Regan, R.G., Wang, Z.H., Nolan, P. &Bradford, A. (1993). Airway PCO2 modifies laryngeal mechanoreceptors independent of the pH of the media perfusing the isolated larynx in the anaesthetised cat. Proc. XXXII IUPS Congress, Glasgow, 1993, 183.3/P.
Wang, Z.H., O’Regan, R.G., &Giles, J.J. (1993). Histochemical demonstration of carbonic anhydrase in the larynx. This volume.
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© 1994 Springer Science+Business Media New York
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Wang, Z.H., Bradford, A., O’Regan, R.G. (1994). Effects of Intralaryngeal CO2 And H+ on Laryngeal Receptor Activity in the Perfused Larynx in Cats. In: O’Regan, R.G., Nolan, P., McQueen, D.S., Paterson, D.J. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 360. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2572-1_71
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DOI: https://doi.org/10.1007/978-1-4615-2572-1_71
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