Abstract
When comparing oxygen consumption rates(V O2) of various organs — as shown in Fig. 1 —skeletal muscle is exceptional in two respects: Its consumption rate attains the second largest absolute value of all organs and may vary between rest (0.2 mlO 2.100g-1’• min -1 ) and maximum performance (16 m1O 2.100g-1 • min -1 for electrical stimulation) by a factor of 80, thus covering a range that is by far larger than in any other tissue. In order to understand muscle O 2 transport one has to identify transport mechanisms and evaluate their importance towards bringing about the observed high O 2 fluxes and allowing for their enormous variability.
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W.J. Federspiel, A model study of intracellular oxygen gradients in a myoglobin-containing skeletal muscle fiber, Biophys.J. 49:857–868 (1986)
T.E.J. Gayeski, C.R. Honig, Intracellular \( {P_{{o_2}}}\) in long axis of individual fibers in working dog gracilis muscle, Am. J.Physiol. 254:H1179–H1186 (1988)
K. Groebe, A versatile model of steady state O 2 supply to tissue. Application to skeletal muscle, Biophys.J. 57:485–498 (1990)
J.D. Hellums, The resistance to oxygen transport in the capillaries relative to that in the surrounding tissue, Microvasc.Res. 13:131–136 (1977)
C.R. Honig, T.E.J. Gayeski, W. Federspiel, A. Clark, P. Clark, Muscle O 2 gradients from hemoglobin to cytochrome: new concepts, new complexities, Adv.Exp.Med.Biol. 169:23–38 (1984)
C.R. Honig, T.E.J. Gayeski, K. Groebe, Myoglobin and oxygen Gradients, pp. 1489–1496 in: “The Lung, Scientific Foundations”, R.G. Crystal, J.B. West et al. (eds.), Raven, New York, 1990
F. Kreuzer, L. Hoofd, Facilitated diffusion of oxygen and carbon dioxide, pp. 89–111 in: “Handbook of Physiology, Sect. 3: The Respiratory System, Vol. IV: Gas Exchange”, L.E. Fahri, S.M. Tenney, eds., American Physiological Society, Bethesda, 1987
A. Krogh, The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue, J.Physiol.(London) 52:409–415 (1918–1919 A)
A. Krogh, The supply of oxygen to the tissues and the regulation of the capillary circulation, J.Physiol.(London) 52:457–474 (1918–1919 A)
A.S. Popel, C.K. Charny, A.S. Dvinsky, Effect of heterogeneous oxygen delivery on the oxygen distribution in skeletal muscle, Math.Biosci. 81:91–113 (1986)
G. Thews, Über die mathematische Behandlung physiologischer Diffusionsprozesse in zylinderförmigen Objekten, Acta Biotheoretica 10:105–137 (1953)
G. Thews, Die Sauerstoffdiffusion im Gehirn, Pflügers Arch. 271:197–226 (1960)
G. Thews, Theoretische Grundlagen für die Bestimmung der Verbrauchsfunktion des kontraktionsabhängig atmenden Muskels, Pflügers Arch. 273:367–379 (1961)
G. Thews, Die Sauerstoffdrücke im Herzmuskelgewebe, Pflügers Arch. 276:166–181 (1962)
G. Thews, Oxygen supply to the dynamically working skeletal muscle, pp. 63–75 in: “Funktionsanalyse biologischer Systeme, Bd. 16”, M. Meyer, N. Heisler (eds.), Akademie der Wissenschaften and der Literatur, G. Fischer, Stuttgart, 1986
J.B. Wittenberg, Myoglobin-facilitated oxygen diffusion: Role of myoglobin in oxygen entry into muscle, Physiol.Rev. 50:559–636 (1970)
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Groebe, K. (1994). O2Transport in Skeletal Muscle: Development of Concepts and Current State. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_3
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_3
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