Abstract
In order to assess the physiological abnormalities and the pathogenesis of adult respiratory distress syndrome (ARDS), especially that associated with pulmonary fat embolism, acute lung injury caused by monounsaturated nonsterified fat oleic acid (cis-9-octadecenoic acid) has been widely used in animal experiments. This lung injury results in an extensive, multifocal, and heterogeneously distributed lung damage with alveolar flooding, interstitial edema and microatelectasis. The ability to reduce the perfusion entering into damaged and edematous areas is essentially important in preserving blood oxygenation in ARDS.
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References
Ball, H.A., Cook, J.A., Spicer, K.M., Wise, W.C., and Halushka, P.V., 1989, Essential fatty acid-deficient rats are resistant to oleic acid-induced pulmonary injury, J. Appl. Physiol., 67:811–816.
Chang, S., Westcott, J.Y., Pickett, W.C., Murphy, R.C., and Volkel, N.F., 1989, Endotoxin-induced lung injury in rats: role of eicosanoids, J. Appl. Physiol., 66:2407–2418.
Coggeshall, J.W., Christman, B.W., Lefferts, P.L., Serafin, W.E., Blair, I.A., Butterfield, M.J., and Snapper, J.R., 1988, Effects of inhibition of 5-lipoxygenase metabolism of arachidonic acid on response to endotoxemia in sheep, J. Appl. Physiol., 65:1351–1359.
Fishman, A.P., 1976, Hypoxia and pulmonary circulation, Cir. Res., 38:221–231.
Hellewell, P.G., Henson, P.T., Downey, G.R., and Worthen, S., 1991, Control of local blood flow in pulmonary inflammation: role for neutrophils, PAF, and thromboxane, J. Appl. Physiol., 70:1184–1193.
Kadowitz, P.J., and Hyman, A.L., 1984, Analysis of responses of leukotriene D4 in the pulmonary vascular bed, Cir. Res., 55:707–717.
Morris, H.R., Piper, P.J., Taylor, G.W., and Tippins, J.R., 1980, The role of arachidonate lipoxygenase in the release of SRS-A from guinea pig chopped lung, Prostaglandins 19:371–383.
Nobel, W.H., and Severinghaus, J.W., 1972, Thermal and conductivity dilution curves for rapid quantitation of pulmonary edema, J. Appl. Physiol., 32:770–775.
Ohtaka, H., Tsang, J.Y., Foster, A., Hogg, J.C., and Schellenberg, R.R., 1987, Comparative effects of leukotrienes on porcine pulmonary circulation in vitro and in vivo, J. Appl. Physiol., 63:582–588.
Olanoff, L.S., Reines, H.D., Spicer, K.M., and Halushka, P.V., 1984, Effects of oleic acid on pulmonary capillary leak and thromboxanes, J. Surg. Res., 36:597–605.
Pearce, M.L., Yamashita, J., Beazell, J., 1965, Measurement of pulmonary edema, Cir. Res., 16:482–488.
Sherr, S., Montemurno, R., and Raffer, P., 1974, Lipids of recovered pulmonary fat emboli following trauma, J. Trauma, 14:242–246.
Schulman, L.L., Lennon, P.F., Ratner, S.J., and Enson, Y., 1988, Meclofenamate enhances blood oxygenation in acute oleic acid lung injury, J. Appl. Physiol., 64:710–718.
Tounsley, M.I., Taylor, G.E., Korthuis, R.J., and Taylor, A.E., 1985, Promethazine or DPPD pretreatment attenuates oleic acid-induced injury in isolated canine lungs, J. Appl. Physiol., 59:39–46.
Wagner, P.D., Saltzmann, H.A., and West, J.B., 1974, Measurement of continuous distributions of ventilation-perfusion ratios: theory, J. Appl. Physiol., 36:588–599.
Yamaguchi, K., Mori, M., Kawai, A., Asano, K., Takasugi, T., Umeda, A., and Yokoyama, T., 1991, Impairment of gas exchange in acute lung injury, Jap. J. Thorac. Dis. 29:134–144.
Yoshimura, K., Tod, M., Pier, K.G., and Rubin, L.J., 1989, Role of venoconstriction in thromboxane-induced pulmonary hypertension and edema in lambs, J. Appl. Physiol., 66:929–935.
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© 1994 Springer Science+Business Media New York
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Yamaguchi, K. et al. (1994). Regulation of Blood Flow in Pulmonary Microcirculation by Vasoactive Arachidonic Acid Metabolites – Analysis in Acute Lung Injury. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_15
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_15
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