Abstract
In the development and differentiation of T cell-associated dendritic cells (epidermal Langerhans cells, interdigitating cells in the paracortex of lymph node, and veiled cells in the dermis and within the afferent lymphatics), the importance of granulocyte-macrophage colony-stimulating factor (GM-CSF) has been pointed out. This fact was based on the results of previous studies of in vitro response of dendritic cells to GM-CSF1 and studies on osteopterosis (op) mice lacking functionally active macrophage colony-stimulating factor (M-CSF).2 Recently, a few groups of investigators have succeeded in generating dendritic cells in cultures of bone marrow cells with GM-CSF in mice3 and humans.4 However, the relationship between dendritic cells and blood monocytes still remains unclear. To elucidate it, it is necessary to investigate the behavior of the dendritic cells in a condition extremely depleted of blood monocyte.
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© 1995 Springer Science+Business Media New York
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Takahashi, K., Araki, M., Miyakawa, K. (1995). Development and Distribution of T Cell-Associated Dendritic Cells in Organs and Tissues of Mice Depleted of Blood Monocytes by Administration of Strontium-89. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_34
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_34
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