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The role of the Ran GTPase pathway in cell cycle control and interphase nuclear functions

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Ran is a small, highly abundant, nuclear GTPase. Mutants in Ran and in proteins that interact with it disrupt the normal checkpoint control of mitosis with respect to the completion of DNA synthesis. Ran and other components of this pathway are also required for numerous nuclear functions such as RNA export, protein import, RNA processing and DNA replication. It will be important to understand how these facets of Ran’s activities are linked and how they promote correct control of the cell cycle. This review examines recent progress in discovering other components of the Ran GTPase pathway and considers how this pathway may be required for the control of the cell cycle.

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Author information

Authors and Affiliations

  1. Laboratory of Molecular Embryology, NICHD, National Institutes of Health, Building 18, Room 101, Bethesda, MD, 20892-5430, USA

    Mary Dasso

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  1. Mary Dasso
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. CFSR Biomedical Science Institute, Austin, Texas, USA

    H. Y. Lim Tung

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© 1995 Springer Science+Business Media New York

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Dasso, M. (1995). The role of the Ran GTPase pathway in cell cycle control and interphase nuclear functions. In: Meijer, L., Guidet, S., Tung, H.Y.L. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1809-9_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1809-9_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5731-5

  • Online ISBN: 978-1-4615-1809-9

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