Abstract
Although boron neutron capture therapy (BNCT) is currently in clinical trials in several countries around the world, the continued development of BNCT for the treatment of cancer patients is dependent on the production of new compounds which exhibit biological characteristics exceeding that of the currently utilized disodium mercaptoundecahydro-closo-dodecaborate (BSH) or para-boronophenylalanine (p-BPA). Specifically, the compounds being developed should have an enhanced tumor uptake and retention, as well as exhibit a higher degree of specificity, particularly in terms of the tumor to blood boron ratio and tumor to normal brain boron ratio. Additionally, the degree of enhancement must be sufficiently significant to invest the resources necessary to produce the quantities required for clinical trials. Thorough reviews of the development of boron-containing compounds for application in BNCT have been published in recent years.1,2 The focus of this review is the research which has been accomplished since the Seventh International Symposium on Neutron Capture Therapy for Cancer, held in Zurich, Switzerland in September, 1996.
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Feakes, D.A. (2001). Chemistry and Pharmacology of Agents for BNCT. In: Hawthorne, M.F., Shelly, K., Wiersema, R.J. (eds) Frontiers in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1285-1_3
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DOI: https://doi.org/10.1007/978-1-4615-1285-1_3
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