The importance of dopamine in the regulation of basal ganglia function and the control of movement has been appreciated for several decades. In the mid 1960’s, histochemical studies established the presence of a dopaminergic nigrostriatal pathway, and neuropathological investigations demonstrated a correlation between dopamine cell loss and Parkinson’s disease (PD) (Anden et al., 1964; Dahlström and Fuxe, 1964; Hornykiewicz, 1966; Poirier and Sourkes, 1966). In the intervening years, a large body of research has provided support for dopamine’s critical role in a range of cognitive and motor functions. In particular, evidence that changes in dopamine receptor stimulation can affect the balance between hypo- and hyperkinetic states has led to considerable interest in how dopamine receptor stimulation ultimately modulates basal ganglia output to permit effective motor control.
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Walters, J.R., Bergstrom, D.A., Molnar, L.R., Freeman, L.E., Ruskin, D.N. (2001). Effects of Dopamine Receptor Stimulation on Basal Ganglia Activity. In: Kultas-Ilinsky, K., Ilinsky, I.A. (eds) Basal Ganglia and Thalamus in Health and Movement Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1235-6_11
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