Abstract
This chapter, written in the spring of 1997, describes the first two clock genes to be characterized in Drosophila.A study of the interactions of period and timeless pointed to a simple mechanism that generates self-sustained molecular oscillations, but that can be reset by exposure to cycles of day and night. Four years later, it is remarkable to see how quickly answers to many of the questions posed in this chapter have emerged. Missing pieces of the clock have been found, and insights from the fruit fly have allowed molecular dissection of human cycles of sleep and wakefulness.
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Young, M.W. (2001). Circadian Timekeeping in Drosophila . In: Takahashi, J.S., Turek, F.W., Moore, R.Y. (eds) Circadian Clocks. Handbook of Behavioral Neurobiology, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1201-1_14
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DOI: https://doi.org/10.1007/978-1-4615-1201-1_14
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