Abstract
The majority of hepatocellular carcinoma (HCC) occurs in patients with liver cirrhosis. Although the tumours are often discovered at an early stage during surveillance of these patients, the underlying cirrhosis renders the surgery more difficult and exposes the patients to higher rates of postoperative morbidity and mortality than occurs in other types of liver surgery. Over the past twenty years surgeons have developed new surgical procedures and techniques to firstly reduce the unnecessary resection of liver parenchyma and to decrease intraoperative blood loss. Better patient selection and understanding of prognostic factors will hopefully result in a further decrease in operative risk and postoperative recurrence. Adjuvant chemotherapy may prove to reduce postoperative recurrence but at this stage surgery still remains as the best treatment for patients with recurrent tumour which is accessible to resection.
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References
Franco D, Capussotti L, Smadja C, Bouzari H, Meakins JL, Kemeny F, et al. Resection of hepatocellular carcinomas in cirrhosis in Europe: results in 72 patients. Gastroenterology 1990; 98: 733–8.
Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Chiu JH, et al. Prognostic significance of surgical margin in hepatocellular carcinoma resection: an analysis of 165 Child’s A patients. J Surg Oncol 1997; 66: 122–6
Franco D, Smadja C, Traynor O, Kahwaji F, Kemeny F, Grange D. Segmentectomies in the management of liver tumours. Arch Surg 1988; 173: 519–522.
Mazziotti A, Cavallari A. Techniques in liver surgery. Greenwich Medical Media 1997.
Capussotti L, Borgonovo G, Bouzari H, Smadja C Grange D, Franco D. Results of major liver resection for large hepatocellular carcinoma in patients with cirrhosis. Br J Surg 1994; 81: 427–31.
Lamoureux P, Franco D. Segmentectomy versus hepatectomy for liver tumours: a plan for segmentectomy. In European IHPBA Congress Athens 95. Mondazzi Editore. S.p.A 1995, pp. 669–674.
Smadja C, Kahwaji F, Berthoux L, Grange D, Franco D. Intérêt du clampage pédiculaire total dans les exérèses hépatiques pour carcinome hépato-cellulaire chez le cirrhotique. Ann Chir 1987; 41: 639–642..
Kimura N, Muraoka R, Huriuchi T, et al. Intermittent hepatic pedicle clamping reduces liver and lung injury. J Surg Res 1998; 15: 11–17.
Elias D, Dube P, Bonvalot S, Debanne B, Plaud B, Lasser P. Intermittent complete vascular exclusion of the liver during hepactectomy: technique and indications. Hepato-Gastroenterology 1998; 45: 389–395.
Emond J, Wachs ME, Renz JF, et al. Total vascular exclusion for major hepatectomy in patients with abnormal liver parenchyma. Arch Surg 1995; 130: 824–830.
Makuuchi M, Mori T, Gunven P, Yamazaki S, Hasegawa H. Safety of hemihepatic vascular occlusion during resection of the liver. Surg Gyne Obst 1987; 164: 155–158.
Izumi R, Shimizu K, II T, et al. Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology 1994; 106: 720–7.
Chen MF, Hwang TL, Jeng LB, Wang CS, Jan YY, Chen SC. Postoperative recurrence of hepatocellular carcinoma in patients undergoing hepatic resection. Arch Surg 1994; 129: 738–42.
Balsells J, Charco R, Lazaro JL, et al. Resection of hepatocellular carcinoma in patients with cirrhosis. Br J Surg 1996; 83: 758–61.
Takenaka K, Kawahara N, Yamamoto K, et al. Results of 280 liver resections for hepatocellular carinoma. Arch Surg 1996; 131:71–6.
Lamoureux P, Bouzari H, Vons C, Capussotti L, Borgonovo G, Smadja C, Franco D. Long-term results of liver resection of hepatocellular carcinoma in cirrhosis. HPB Surgery 1996; 9(S): 18.
Nakajima Y, Shimamura T, Kamiyama T, et al. Evaluation of surgical resection for small hepatocellular carcinomas. Am J Surg 1996; 171: 360–3.
Lee CS, Sheu JC, Wang M, Hsu HC. Long term outcome after surgery for asymptomatic small hepatocellular carcinoma. Br J Surg 1996; 8: 330–3.
Okada S, Siiimada K, Yamamoto J, et al. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 1994; 106: 1618–24.
Shirabe K, Kanematsu T, Matsumata T. Adachi E, Akazawa K, Sugimachi K. Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analyses. Hepatology 1991; 14: 802–5.
El-Assal ON, Yamanoi A, Soda Y, Yamaguchi M, Yu L, Nagasue N. Proposal of invasiveness score to predict recurrence and survival after curative hepatic resection for hepatocellular carcinoma. Surgery 1997; 122: 571–7.
Belghiti J, Pants Y, Farges O, Benhamou JP, Fekete F. Intrahepatic recurrence after resection of hepatocellular carcinoma complicating cirrhosis. Ann Surg 1991; 214: 114–7.
Terris B, Laurent-Puig P, Belghiti J, Degott C, Henin D, Flejou JF. Prognostic influence of clinicopathologic features; DNA-ploidy, CD44h and p53 expression in a large series of resected hepatocellular carcinoma in France. Int J Cancer 1997; 74: 614–9.
Lemoine A, Le Bricon T, Salucci M, Azoulayd, Phamp, Raccuta J, et al. Prospective evaluation of circulating hepatocytes by alpha-fetoprotein mRNA in humans during liver surgery. Ann Surg 1997; 226: 43–50.
Majno PE, Adam R, Bismuth H, Castaing D, Ariche A, Krissat, et al. Influence of preoperative transarterial lipiodol chemoembolisation on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis. Ann Surg 1997; 226: 688–701.
Yu YQ, Xu DB, Zhou XD, Lu JZ, Tang ZY, Mack P. Experience with liver resection after hepatic arterial chemoembolisation for hepatocellular carcinoma. Cancer 1993; 71: 62–5.
Harada T, Matsuo K, Inoue T, Tamesue S, Inoue T, Nakamura H. Is preoperative hepatic arterial chemoembolisation safe and effective for hepatocellular carcinoma? Ann Surg 1996; 224: 4–9.
Wu CC, Ho YZ, Ho WL, Wu TC, Liu TJ, P’eng FK. Preoperative transcatheter arterial chemoembolization for resectable large hepatocellular carcinom: a reappraisal. Br J Surg 1995; 82: 122–6.
Kohno H, Nagasue N, Hayashi T, Yamanoi A, Uchida M, Ono T, Hukaya H, Kimura N, Nakamura T Postoperative adjuvant chemotherapy after radical hepatic resection for hepatocellular carcinoma (HCC). Hepat-Gastroenterology 1996; 43: 1405–9.
Yamamoto M, Aril S, Sugahara K, Tobe T. Adjuvant oral chemotherapy to prevent recurrence after curative resection for hepatocellular carcinoma. Br J Surg 199; 83: 336–40.
Suenaga M, Sugiura H, Kokuba Y, Uehara J, Kurumiya T. Repeated hepatic resection for recurrent hepatocellular carcinoma in eighteen cases. Surgery 1994; 115: 452–7.
Matsuda Y, Toshikazu I, Oguchi Y, Nakajima K, Izukura T. Rationale of surgical management for recurrent hepatocellular carcinoma. Ann Surg 1993; 217: 28–34.
Shimada M, Matsumata T, Taketomi A, Yamamoto K, Itasaka H, Sugimachi K. Repeat hepatectomy for recurrent hepatocellular carcinoma. Surgery 1994; 115: 706–6.
Sbai-Idrissi MS, Vons C, Borgonovo G, Mariette D, Smadja C, Franco D. Traitement des récidives hépatiques après résection des carcinomes hépatocellulaires. Ann Chir 1998; 52: 543–546.
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Franco, D., Usatoff, V. (2002). Resection of Hepatocellular Carcinoma. In: Habib, N.A. (eds) Multi-Treatment Modalities of Liver Tumours. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0547-1_1
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DOI: https://doi.org/10.1007/978-1-4615-0547-1_1
Publisher Name: Springer, Boston, MA
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