Abstract
Substrates, intermediary metabolites and products, the so called “global metabolite pool”, constitute a living organism’s metabolome. Variations and changes in components of the metabolome reflect adaptation of an organism to its microenvironment, as defined by substrate availability and hormonal milieu, through altered gene expression and through the activation of signaling cascades (Tweeddale et al., 1998). The major regulatory components of cell function, the genome, transcriptome and proteome, ultimately act on the metabolome resulting in the expression of a specific phenotype. The close interactions among these components establish a rationale for integrating functional genomics, proteomics and metabolomics, as a means to study the complete intracellular signal processing apparatus that regulates metabolic adaptation, phenotype and ultimately cellular function (Kell and King, 2000).
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Boros, L.G., Cascante, M., Lee, WN.P. (2003). Stable Isotope-Based Dynamic Metabolic Profiling in Disease and Health. In: Harrigan, G.G., Goodacre, R. (eds) Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0333-0_9
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DOI: https://doi.org/10.1007/978-1-4615-0333-0_9
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