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Pharmacology of Cyclic ADP-Ribose and NAADP

Synthesis and Properties of Analogs

  • Chapter
Cyclic ADP-Ribose and NAADP

Abstract

Multiple Ca2+ stores are generally present in cells. Principal among them are the mitochondria and the endoplasmic reticulum. It is generally accepted that inositol trisphosphate mobilizes Ca2+ stores in the endoplasmic reticulum [1]. Also present in the organelle is another Ca2+ release channel, the ryanodine receptor. The discovery of two other Ca2+ signaling molecules, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) [2–4] further highlights the complexity of Ca2+ mobilization as a fundamental signaling mechanism [1].

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    Timothy F. Walseth & Hon Cheung Lee

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Walseth, T.F., Lee, H.C. (2002). Pharmacology of Cyclic ADP-Ribose and NAADP. In: Lee, H.C. (eds) Cyclic ADP-Ribose and NAADP. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0269-2_7

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