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Function of PACAP in the Hypothalamo-Pituitary Complex

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Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

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Abstract

It is widely known that the original naming of the pituitary adenylate cyclase-activating polypeptide (PACAP) after its isolation by Arimura and colleagues derived from the ability of this peptide to increase cAMP production in cultures of rat pituitary cells (Miyata et al, 1989). This observation, together with the accompanying report that PACAP stimulates the release of most pituitary hormones from superfused rat pituitary cells, strongly suggested that PACAP was a new and important hypophysiotropic factor. Subsequent studies failed to demonstrate such a clear role for PACAP, while progressively revealing a number of important functions for this peptide in other tissues and organs. This has prompted an exciting and enduring debate on the true hypophysiotropic functions of PACAP. In this chapter, we review and update the most relevant findings on the study of the functions and mechanisms of action of PACAP in the hypothalamus and the pituitary gland.

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Authors and Affiliations

  1. Department of Cell Biology, University of CÓrdoba, CÓrdoba, E-14071, Spain

    M. Malagón, J. P. Castaño, S. García-Navarro, A. J. Martínez-Fuentes & F. Gracia-Navarro

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  1. M. Malagón
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  2. J. P. Castaño
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  3. S. García-Navarro
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  4. A. J. Martínez-Fuentes
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  5. F. Gracia-Navarro
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  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Malagón, M., Castaño, J.P., García-Navarro, S., Martínez-Fuentes, A.J., Gracia-Navarro, F. (2003). Function of PACAP in the Hypothalamo-Pituitary Complex. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_7

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