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PACAP in the Urogenital Tract

  • Chapter
Pituitary Adenylate Cyclase-Activating Polypeptide

Part of the book series: Endocrine Updates ((ENDO,volume 20))

Abstract

Several biologically active peptides have been shown to occur in the mammalian urogenital tract (Fahrenkrug and Gras, 2001). Information on the various peptides varies considerably from the mere demonstration of peptide immunoreactivity in tissue extracts to detailed studies on cellular localization, physiological and pathophysiological role. Today the best examined peptide is undoubtedly the vasoactive intestinal polypeptide (VIP). VIP has been shown to be a neurotransmitter in the local nervous control of blood flow and motility and it is involved in functions such as ovum transportation, vaginal lubrication and penile erection (Fahrenkrug, 1993; Ottesen and Fahrenkrug, 1995). The strong sequence homology between VIP and PACAP made it obvious to look for the occurrence of both PACAP38 and the C-terminally truncated PACAP27 in the urogenital tract. Although there is still a long way to go before the role of PACAP in the urogenital tract is clarified a number of studies have clearly demonstrated that PACAP could be a sensory and efferent neurotransmitter as well as having autocrine/paracrine functions.

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Authors and Affiliations

  1. Bispebjerg Hospital, University of Copenhagen, Dept. of Clinical Biochemistry, Copenhagen, NV, DK-2400, Denmark

    J. Fahrenkrug, J. Hannibal & S. Gräs

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  1. J. Fahrenkrug
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  2. J. Hannibal
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  3. S. Gräs
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Editors and Affiliations

  1. European Institute for Peptide Research, INSERM Unit 413, University of Rouen, Mont-Saint-Aignan, France

    Hubert Vaudry

  2. US Japan Biomedial Research Laboratories, Tulane University, Belle Chasse, Louisiana, USA

    Akira Arimura

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Fahrenkrug, J., Hannibal, J., Gräs, S. (2003). PACAP in the Urogenital Tract. In: Vaudry, H., Arimura, A. (eds) Pituitary Adenylate Cyclase-Activating Polypeptide. Endocrine Updates, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0243-2_11

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