Photochemical damages to the biological system may occur through photodynamic action in the presence of photosensitive molecules. Photodynamic action contains the following processes; 1) photosensitisation and/or 2) electron transfer, in which singlet oxygen and superoxide radical production for each in the presence of oxygen molecules. We have studied those processes after the absorption of light by kynurenine pathway metabolites and indoleamine derivatives. We found that kynurenine and 3hydroxykynurenine generate superoxide radical after electron transfer from their excited state molecules to oxygen molecules, and superoxide makes reduction reaction. On the other hand, it was found that kynurenic acid, melatonin, 5-methoxytryptamine and 5methoxytryptophol work as photosensitisers with the detection of singlet oxygen production by using the N, N-dimethyl-4-nitrosoaniline bleaching method, while xanthurenic acid, serotonin and N-acetylserotonin generate no detectable amount of singlet oxygen. We have determined the photochemical quantum yields of singlet oxygen production for those photosensitisers, in which quantum yields are not so high except kynurenic acid(f 3 =0.101). In view of the multiple roles played by their metabolites in various systems, these results are relevant to taking into consideration of their photo-effect in the presence of light.
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P. Warlant and R. Santus, N-formylkynurenine, a tryptophan photooxidation product, as a photodynamic sensitizerPhotochem. Photobiol.19, 411–417 (1974).
R.M. Krishna, S. Uppuluri, P. Riesz, J.S. ZiglerJRand D. Balasubramanian, A study of the photodynamic efficiencies of some eye lensconstituents,Photochem. Photobiol. 54,51–58 (1991).
M.L. Walker and R.F. Borkman, Light scattering and photocrosslinking in the calf lens crystallins gamma-11, 111 and1V Exp. Eye. Res. 48, 375–383 (1989).
J. Dilon, and S.J. Atherton, Time resolved sppectroscopic studies on the intact humaneye Photochem. Photobiol. 51, 465–468 (1990).
K. Goda, M. Hisaoka and T. Ueda, Photoinduced electron transfer reaction from N-formylkynurenine and Lkynurenine to cytochrome cBiochem. /nt. 15.635–641 (1987).
I. Kraljic and S. El Mohsni, A new method for the detection of singlet oxygen in aqueous solutionPhotochem. Photobiol. 28,577–581 (1978).
E. Gandin, Y. Lion and A Van de Vorst, Quantum yield of singlet oxygen production by xanthene derivativesPhotochem. Photobiol. 37,271–178 (1983).
P.C.C. Lee and M.A.I. Rodgers, Laser photokinetic studies of rose bengal sensitized phoyodynamic interactions of nucleotides and DNA. Photochem. Photobiol28,79–86 (1987).
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Goda, K., Amako, K., Kishimoto, R., Ogiri, Y. (2003). Photochemical Properties of Kynurenine Pathway Metabolites and Indoleamines. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology, vol 527. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_81
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DOI: https://doi.org/10.1007/978-1-4615-0135-0_81
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