Abstract
Upon damage to mammalian tissues, such as destruction due to infection, inflammation, neoplasia, burn wounds, and mechanical trauma, a complex series of events must follow in order to prevent further damage, and to restore homeostasis. The sum of these events is known as inflammation, of which the acute-phase response constitutes the set of immediate and early events. Local acute-phase reactions include aggregation of platelets, dilation and subsequent leakage of blood vessels, release of protease inhibitors, and release of cytokines and chemoattractant molecules. The latter attract leukocytes, which in turn, together with the fibroblasts and endothelial cells at the site of inflammation will produce more cytokines, like TNF-α, IL-lβ and IL-6.
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Van Dijk, W., Poland, D.C.W. (2003). Anti-Inflammatory Properties of Specific Glycoforms of Human α1-Acid Glycoprotein. In: Axford, J.S. (eds) Glycobiology and Medicine. Advances in Experimental Medicine and Biology, vol 535. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0065-0_16
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DOI: https://doi.org/10.1007/978-1-4615-0065-0_16
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