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CD34+ Cells in Hematopoietic Stem Cell Transplantation

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Tissue Engineering, Stem Cells, and Gene Therapies

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 534))

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Abstract

Infusion of CD34+ cells, either autologous or allogeneic are being utilized with increasing frequency following the administration of myeloablative chemoradiotherapy for the treatment of hematologic malignancies or solid tumors. CD34+ cell collection does not require hospital admission or exposure to general anesthesia. Furthermore, many studies clearly documented rapid engraftment of both neutrophils and platelets with mobilized CD34+ cells compared to BM. In this article, we will review issues concerning the optimization of yield, impact of the number of collected CD34+ cells and factors influencing the engraftment after hematopoietic stem cell transplantation (HSCT).

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Authors and Affiliations

  1. Department of Hematology/Oncology and Bone Marrow Transplant Unit, Ankara University Medical School, Ibn-i Sina Hospital, Sihhiye, Ankara, 06100, Turkey

    Taner Demirer

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  1. Taner Demirer
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  1. Science Faculty and Biotechnology Institute, Ankara University, Ankara, Turkey

    Y. Murat Elçin

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Demirer, T. (2003). CD34+ Cells in Hematopoietic Stem Cell Transplantation. In: Elçin, Y.M. (eds) Tissue Engineering, Stem Cells, and Gene Therapies. Advances in Experimental Medicine and Biology, vol 534. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0063-6_8

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  • DOI: https://doi.org/10.1007/978-1-4615-0063-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4907-5

  • Online ISBN: 978-1-4615-0063-6

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