Abstract
Platelet responses to many agonists involve rapid stimulation of calcium fluxes and turnover of phosphoinositides. A rise in cytoplasmic free calcium, [Ca2+]i, has been regarded as the final common pathway for shape change, secretion, and aggregation; phosphoinositide turnover has been viewed mainly as a means of mobilizing calcium [and as one route for releasing arachidonate for formation of thromboxane A2 (TxA2)]. However, much of the evidence is indirect and interpretation necessarily speculative. Two recent developments have allowed a more informed analysis of second messenger pathways.
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© 1985 Plenum Press, New York
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Rink, T.J., Tsien, R.Y., Sanchez, A., Hallman, T.J. (1985). Calcium and Diacylglycerol. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_18
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DOI: https://doi.org/10.1007/978-1-4613-2377-8_18
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