Abstract
Taurine is universally present in mammalian tissues, often at extremely high concentrations. Its functionality in mammals is indicated by the pathological consequences of taurine depletion, and the numerous beneficial pharmacological actions of taurine [1]. These facts suggest that taurine has generalized functions applicable to all cells and that these functions are mediated via low-affinity interactions of taurine with cellular structures. The phenomena with which taurine is involved can be clustered under basic processes such as osmoregulation, antioxidation, metabolic actions (stimulation of glycolysis and glycogenesis, and substrate for bile salt synthesis), and ion regulation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Huxtable RJ, Sebring LA. 1986. Towards a unifying theory for the actions of taurine. Trends Pharm Sci 7:481–485.
Huxtable RJ. 1976. Metabolism and function of taurine in the heart. In Taurine, Huxtable RJ, Barbeau A, eds. New York: Raven Press, pp 99–119.
Huxtable RJ, Sebring LA. 1983. Cardiovascular actions of taurine. In Sulfur amino acids: Biochemical and clinical aspects, Kuriyama K, Huxtable RJ, Iwata H, eds. New York: Alan R. Liss, pp 5–37.
Sebring LA, Huxtable RJ. 1985. Taurine modulation of calcium binding to cardiac sarcolemma. J Pharm Exp Ther 232:445–451.
Schaffer SW, Seyed-Mozaffari M, Kramer J, Tan BH. 1985. Effect of taurine depletion and treatment on cardiac contractility and metabolism. In Taurine: Biological actions and clinical perspectives, Oja SS, Ahtee L, Kontro P, Paasonen MK, eds. New York: Alan R. Liss, pp 167–175.
Franconi F, Giotti A, Manzini S, Martini F, Stendardi I, Zilletti L. 1982. Observations on the action of taurine at arterial and cardiac levels. In Taurine in nutrition and neurology, Huxtable RJ, Pasantes-Morales H, eds. New York: Plenum Press, pp 181–190.
Franconi F, Martini F, Stendardi I, Matucci R, Zilletti L, Giotti A. 1982. Effect of taurine on calcium levels and contractility in guinea pig ventricular strips. Biochem Pharmacol 31:3181–3186.
Bers DM, Philipson KD, Langer GA. 1981. Cardiac contractility and sarcolemmal calcium binding in several cardiac muscle preparations. Am J Physiol 240:H576-H583.
Sebring LA, Huxtable RJ. 1986. Low affinity binding of taurine to phospholiposomes and cardiac sarcolemma. Biochim Biophys Acta 884:559–566.
Fabiato A, Fabiato F. 1979. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol Paris 75:463–505.
Huxtable RJ, Sebring L. 1982. Cardiovascular actions of taurine. Sulfur Amino Acids 5:29–51 (Reprint with modification of Reference [3]).
Fabiato A, Baumgarten CM. 1984. Methods for detecting calcium release from the sarcoplasmic reticulum of skinned cardiac cells and the relationships between calculated trans-sarcolemmal calcium movements and calcium release. In Physiology and pathophysiology of the heart, Sperelakis N, ed. Boston: Martinus Nijhoff, pp 215–254.
Fabiato A. 1985. Calcium both activates and inactivates calcium release from cardiac sarcoplasmic reticulum. In Calcium in biological systems, Rubin RP, Weiss GB, Putney JW Jr, eds. New York: Plenum Publishing, pp 369–375.
Fabiato A. 1985. Calcium-induced release of calcium from the sarcoplasmic reticulum. J Gen Physiol 85:189–320.
Huxtable RJ. 1980. The regulation and function of taurine in the heart and other organs. In Natural sulfur compounds: Novel biochemical and structural aspects, Cavallini D, Gaull GE, Zappia V, eds. New York: Plenum Press, pp 227–293.
Grosso DS, Roeske WR, Bressler R. 1978. Characterization of a carrier-mediated transport system for taurine in the fetal mouse heart in vitro. J Clin Invest 61:944–952.
Franconi F, Martini F, Manghi N, Galli A, Bennardini F, Giotti A. 1981. Uptake of [3H]taurine into myocardial membranes. Biochem Pharmacol 30:77–80.
Franconi F, Martini F, Bennardini F, Mangiapane A, Giotti A. 1981. Taurine uptake in sarcolemma vesicles isolated from hypertrophic guinea-pig hearts. Biochem Pharmacol 30:693–695.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers, Boston/Dordrecht/London
About this chapter
Cite this chapter
Huxtable, R.J., Sebring, L.A. (1989). Taurine and the Heart: The Phospholipid Connection. In: Iwata, H., Lombardini, J.B., Segawa, T. (eds) Taurine and the Heart. Developments in Cardiovascular Medicine, vol 93. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1647-3_3
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1647-3_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8915-9
Online ISBN: 978-1-4613-1647-3
eBook Packages: Springer Book Archive