Abstract
Urea is a small, uncharged, yet highly soluble organic solute. Because of its high diffusibility, it finds its way easily across nearly all biological membranes by simple or facilitated diffusion. The result is rapid and complete equilibration among all aqueous body compartments (1). Transport of urea from its site of production in the liver is relatively unimpeded and, at equilibrium, tissue water concentrations are equal throughout the organism with one exception.
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Depner, T.A. (1991). Multicompartment Models. In: Prescribing Hemodialysis. Developments in Nephrology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1509-4_5
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DOI: https://doi.org/10.1007/978-1-4613-1509-4_5
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