Abstract
Traditional near infrared-time resolved spectroscopy (NIR-TRS) analysis includes fitting a spectrum with a known analytical solution to obtain the media absorption and scattering coefficients or computing mean time-of-flight for heterogeneity localization. The benefit of applying frequency response analysis to NIR-TRS data reduction is that magnitude ratio (MR) and phase shift (φ) information in a wide frequency range can be obtained from a single TRS spectrum. The sharper the input pulse is the wider the frequency range values one can obtain. This analysis has been applied to NIR-TRS spectra to obtain optical parameters from homogeneous systems (Kang et al., in press) and for localizing absorbers in heterogeneous systems (Kang et al., 1994). MR and φ can also be obtained from phase modulation spectroscopy (PMS). PMS, however, provides these values at a fixed modulation frequency unless the instrument is sophisticated enough to change the modulation frequency in a wide range. Another benefit is that multiple system parameters can be obtained from a single TRS spectrum, i.e., MR, φ, steady state gain (K), break frequency (fb)/time constant (τ), and system order (n). Steady state gain (K) is a valuable parameter that can be used to check system linearity. Other new parameters (fb/τ, n) are still to be studied in an optical sense.
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© 1996 Plenum Press New York
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Kang, K.A., Bruley, D.F., Kitai, T., Chance, B. (1996). System Parameter Analysis of Nir-Trs Spectra from Homogeneous Media with and without an Absorbing Boundary and from Heterogeneous Media with a Single Absorber. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_53
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DOI: https://doi.org/10.1007/978-1-4613-0333-6_53
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