Abstract
The outcome of therapy for solid tumours is modulated by many factors (Hall, 1978). The most important modulator of response to radiation therapy is the presence of oxygen. Cells that are severely hypoxic are approximately 3 times more resistant to low LET radiation (used in radiotherapy) than well oxygenated cells. Chemotherapeutic efficacy may also be adversely affected by oxygen deprivation (Tannock & Guttman, 1981).
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Brown, J. M. (1979). Evidence for acutely hypoxic cells in mouse tumours and a possible mechanism of reoxygenation. Br. J. Radiol., 52, 650–656.
Hall, E. J. (1978). Radiobiology for radiologists (2nd ed.). Philadelphia: Harper & Row.
Minchinton, A. I. (In press). Differences in the tumour oxygen tension in mice and man. Acta Oncologica, Tannock, I., & Guttman, P. (1981). Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions. Br. J. Cancer, 43, 245–248.
Tannock, I., & Guttman, P. (1981). Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions. Br. J. Cancer, 43245–248.
Thomlinson, R. H., & Gray, L. H. (1955). The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer, 9, 539–549.
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© 1996 Plenum Press, New York
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Minchinton, A.I., Fryer, K.H. (1996). Fluctuations in the Oxygenation of Experimental Tumours. In: Ince, C., Kesecioglu, J., Telci, L., Akpir, K. (eds) Oxygen Transport to Tissue XVII. Advances in Experimental Medicine and Biology, vol 388. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0333-6_45
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DOI: https://doi.org/10.1007/978-1-4613-0333-6_45
Publisher Name: Springer, Boston, MA
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