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Animal Models in Biomedical Research and Radiotracer Design

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Animal Models in Radiotracer Design

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Abstract

Radiopharmaceutical science and the design of radiotracers to probe biochemical and physiological processes in animal models and man are rapidly growing fields (Eckelman, 1982; Fowler and Wolf, 1982; Lambrecht and Morcos, 1982; Glenn, 1982). Tracers labeled with short-lived radionuclides (radiopharmaceuticals) are finding applications in nuclear medicine for the diagnosis and treatment of disorders and disease. But ethical, legal, and practical constraints limit experimentation in humans such as described by Cohen (1953). As a result, the animal model provides a scientifically valid and moral approach to the development of knowledge and contributes to animal and human welfare (NAS, 1981). It is not uncommon that the enthusiastic and well-intended researcher following the suggestion of a clinician has prepared a radiotracer in search of a disease, rather than having proceeded by analytical dissection of the scientific literature to arrive at a decision as to which radiotracer should be targeted against which disease or fundamental question in a carefully chosen animal model. “An animal model of a disease is only as useful as the questions we ask of it” (Reid, 1980). Regardless of the nature of the experiment, the experimentalist is required to incorporate the rational selection of a suitable animal model(s) as part of the experimental design.

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  1. Richard M. Lambrecht
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  2. William C. Eckelman
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  3. Aldo Rescigno
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Editors and Affiliations

  1. Chemistry Department, Brookhaven National Laboratory, 11973, Upton, NY, USA

    Richard M. Lambrecht

  2. Section of Radiopharmaceutical Chemistry, George Washington University Medical Center, 20037, Washington, DC, USA

    William C. Eckelman

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Lambrecht, R.M., Eckelman, W.C., Rescigno, A. (1983). Animal Models in Biomedical Research and Radiotracer Design. In: Lambrecht, R.M., Eckelman, W.C. (eds) Animal Models in Radiotracer Design. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5596-3_1

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