Abstract
This chapter briefly summarizes instances in which proteolytic cleavage of viral structural proteins has been demonstrated to play a direct role in pathogenesis. It does not attempt to cover the extensive literature on the proteolytic processing of polyproteins, which is an essential step in virus replication, e.g., in picornaviruses or togaviruses, but has not been shown to be a determinant of pathogenesis other than in the broad sense that biosynthesis of viral components is required for viral replication. Emphasis is placed on those viruses for which cleavage by host proteases has been shown to be a major determinant of virulence, i.e., on paramyxoviruses and myxoviruses [1].
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© 1984 Springer-Verlag New York Inc.
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Scheid, A., Choppin, P.W. (1984). Proteolytic Cleavage and Virus Pathogenesis. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_4
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DOI: https://doi.org/10.1007/978-1-4612-5250-4_4
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