Abstract
In the ribosomal elongation cycle, the translocation probably is the step exhibiting the highest complexity (Spirin, 1983). After the formation of a peptide bond, the ribosome carries deacylated tRNA in the P site and peptidyl-tRNA (pept-tRNA) in the A site, both being bound to the mRNA by codon-anticodon interaction (“pretranslocation complex”). During translocation, which in Escherichia coli is catalyzed by elongation factor G (EF-G) and GTP, the deacylated tRNA is released from the P site and the pept-tRNA is displaced from the A to the P site, carrying the mRNA along.
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Wintermeyer, W., Lill, R., Paulsen, H., Robertson, J.M. (1986). Mechanism of Ribosomal Translocation. In: Hardesty, B., Kramer, G. (eds) Structure, Function, and Genetics of Ribosomes. Springer Series in Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4884-2_30
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DOI: https://doi.org/10.1007/978-1-4612-4884-2_30
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