Abstract
In July 1976, an outbreak of acute respiratory illness occurred during an American Legion convention in Philadelphia, Pennsylvania. Of 4,400 attendees, and some other individuals not directly associated with the convention, 221 became ill and 34 of these cases died (Fraser et al., 1977). The cause of the epidemic was unknown until later that year, when investigators at the Centers for Disease Control isolated the responsible bacterium, subsequently termed Legionella pneumophila (lung-loving) (McDade et al., 1977).
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References
Abrams, A.P., Garbett, M., Rees, H.B., and Lewis, B.G. 1980. Bacterial aerosols produced from a cooling tower using wastewater effluent as makeup water. Journal of Water Pollution Control Federation 52: 498–501.
Anand, C.M., Skinner, A.R., Malic, A., and Kurta, J.B. 1983. Interaction of L. pneumophila and a free-living amoeba (Acanthamoeba palestinenis). Journal of Hygiene 91: 167–178.
Antopol, S.C. and Ellner, P.D. 1979. Susceptibility of Legionella pneumophila to ultraviolet radiation. Applied and Environmental Microbiology 38: 347–348.
Arnow, P.M., Weil, D., and Para, M.F. 1985. Prevalence and significance of Legionella pneumophila contamination of residential hot-tap water systems. Journal of Infectious Diseases 152: 145–151.
Band, J.D., La Venture, M., David, J.P., Mallison, G.F., Skaliy, P., Hayes, P.S., Schell, W.L., Weiss, H., Greenberg, D.J., and Fraser, D.W. 1981. Endemic Legionnaires Disease: Airborne transmission down a chimney. Journal of the American Medical Association 245: 2404–2407.
Barbaree, J.M., Fields, B.S., Feeley, J.C., Gorman, G.W., and Martin, W.T. 1986. Isolation of protozoa from water associated with a legionellosis outbreak and demonstration of intracellular multiplication of Legionella pneumophila. Applied and Environmental Microbiology 51: 422–424.
Barbaree, J.M., Gorman, G.W., Martin, W.T., Fields, B.S., and Morrill, W.E. 1987. Protocol for sampling environmental sites for legionellae. Applied and Environmental Microbiology 53: 1454–1458.
Bartlett, C.LR. Macrae, A.D., and MacFarlane, J.T. 1986. Legionella Infections, Edward Arnold, Ltd. London, U.K.
Berendt, R.F. 1981. Influence of blue-green algae (cyanobacteria) on survival of Legionella pneumophila in aerosols. Infection and Immunity 32: 690–692.
Berg, J.D., Hoff, J.C., Roberts, P.V., and Matin, A. 1984. Growth of Legionella pneumophila in continuous culture and its sensitivity to inactivation by chlorine dioxide, pp. 68–70 in Thornsberry, C., Balows, A., Feeley, J.C., and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium, American Society for Microbiology, Washington, DC.
Berg, J.D., Hoff, J.C., Roberts, P.V., and Matin, A. 1985. Disinfection resistance of Legionella pneumophila and Escherichia coli grown in continuous and batch culture, pp. 603–613 in Jolly, R.L., Bull, R.L., Davis, W.P., Katz, S., Roberts, M.H., and Jacobs, V.A. (editors), Water Chlorination: Environmental Impact and Health Effects, Vol. 5. Lewis Publishers.
Best, M., Stout, J., Muder, R.R., Yu, V.L., Goetz, A., and Taylor, F. 1983. Legionellosis in the hospital water supply. Lancet ii:307–310.
Bopp, C.A., Sumner, J.W., Morris, G.K., and Wells, J.G. 1981. Isolation of Legionella spp. from environmental water samples of low pH treatment and use of a selective medium. Journal of Clinical Microbiology 13: 714–719.
Bornstein, N., Veilly, C, Nowicki, M., Paucod, J.C., and Fleurett, J. 1986. Epidemiological evidence of legionellosis transmission through domestic hot water supply systems and possibilities of control. Israel Journal of Medical Sciences 22: 655–661.
Broome, C.V. 1984. Current issues in epidemiology of legionellosis. pp. 205–209 in Thornsberry, C., Balows, A., Feeley, J.C., and Jakubowski, W. (editors), Legionella: Proceedings of The Second International Symposium, American Society for Microbiology, Washington, DC.
Calderon, R.L. and Dufour, A.P. 1984. Media for detection of Legionella spp. in environmental water supplies, pp. 290–292 in Thornsberry, C., Balows, A., Feeley, J. and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium, American Society for Microbiology, Washington, D.C.
Carson, L.A., Favero, M.S., Bond, WW, and Peterson, N.J. 1972. Factors affecting comparative resistance of naturally occurring and subcultured Pseudomonas aeruginosa to disinfectants. Applied and Environmental Microbiology 23: 863–869.
Carter, R.F. 1970. Description of a Naegleria species isolated from two cases of primary amoebic meningoencephalitis and of the experimental pathological changes induced by it. Journal of Pathology 100: 217–244.
Chang, S.L. 1978. Resistance of pathogenic Naegleria to some common physical and chemical agents. Applied and Environmental Microbiology 35: 368–375.
Characklis, W.C., Trulear, M.C., Stathopoulos, N., and Chang, L.C. 1980. Oxidation and destruction of microbial films, pp. 349–368 in Jolly, R.L. (editor). Water Chlorination: Environmental Impact and Health Effects, Butterworth Publishers, Stoneham, Massachusetts.
Chartered Institution of Building Services Engineers. 1987. Minimizing the Risk of Legionnaires Disease, Technical Memorandum (TM) 13, London.
Colbourne, J.S., Pratt, P.J., Smith, M.G., Fisher-Hoch, S.P., and Harper, D. 1984. Water fittings as sources of Legionella pneumophila in a hospital plumbing system. Lancet i:210–213.
Colboume, J.S. and Trew, R.M. 1986. Presence of Legionella in London’s water supplies. Israel Journal of Medical Sciences 22: 633–639.
Colbourne, J.S., Dennis, P.J., Trew, R.M., Berry, C., and Vesey, G. 1988. Legionella and public water supplies, pp. 31–36 in Proceedings of the International Conference on Water and Wastewater Microbiology, Newport Beach, California.
Cordes, L.G., Wisenthal, A.M., Gorman, G.W, Phair, J.P., Sommers, H.M., Brown, A., Yu, V.L., Magnussen, M.H., Meyer, R.D., Wolf, J.S., Shands, K.N., and Fraser, D.W. 1981. Isolation of Legionella pneumophila from shower heads. Annals of Internal Medicine 94: 195–197.
Cordes, LG., Fraser, D.W., Skaliy, P., Perlino, C.A., Elsea, W.R., Mallison, G.F., and Hayes, P.S. 1980. Legionnaires disease outbreak at an Atlanta, Georgia, country club: Evidence for spread from an evaporative condenser. American Journal of Epidemiology 111: 425–431.
Dejonckheere, J. and van de Voorde, H. 1975. Differences in destruction of cysts of pathogenic and nonpathogenic Naegleria and Acanthamoeba by chlorine. Applied and Environmental Microbiology 31: 294–297.
Dennis, P.J., Bartlett, C.L.R., and Wright, A.E. 1984. Comparison of isolation methods for Legionella spp. pp. 294–296 in Thornsberry, C., Balows, A., Feeley, J. and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium, American Society for Microbiology, Washington, DC.
Dennis, P.J., Green, D., and Jones, B.P. 1984. A note on the temperature tolerance of Legionella. Journal of Applied Bacteriology 56: 349–350.
Department of Health and Social Security and the Welsh Office. 1989. The Control of Legionellae in Health Care Premises: A Code of Practice, Her Majesty’s Stationery Office, London.
Desplaces, N., Bure, A., and Dournon, E. 1984. Legionella spp. in environmental water samples in Paris, pp. 320–321 in Thornsberry, C., Balows, A., Fecley, J.C. and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium, American Society for Microbiology. Washington, D.C.
Dominque, E.L., Tyndall, R.L., Mayberry, W.R., and Pancorbo, O.C. 1988. Effects of three oxidizing biocides on Legionella pneumophila serogroup 1. Applied and Environmental Microbiology 54: 741–747.
Dondero, T.J., Rendtorff, R.C., Mallison, G.F., Weeks, R.M., Levy, J.S., Wong, E.W, and Schaffner, W. 1980. An outbreak of Legionnaires disease associated with a contaminated air conditioning coding tower. New England Journal of Medicine 302: 362–370.
Dournan, E. Bibb, W.F., Rajagopalan, P., Desplaces, N., and McKinney, R.M. 1988. Monoclonal antibody reactivity as a virulence marker for Legionella pneumophila serogroup 1 strains. Journal of Infectious Diseases 157: 496–501.
Dutka, B.J. 1984. Sensitivity of Legionella pneumophila to sunlight in fresh and marine waters. Applied and Environmental Microbiology 48: 970–974.
Edelstein, P.H., Whittaker, R.E., Kreiling, R.L, and Howell, C.L. 1982. Efficacy of ozone in eradication of Legionella pneumophila from hospital plumbing fixtures. Applied and Environmental Microbiology 44: 1330–1334.
Edelstein, PH. 1982. Comparative study of selective media for isolation of Legionella pneumophila from potable water. Journal of Clinical Microbiology 16: 697–699.
Edelstein, PH. 1985. Environmental aspects of Legionella. American Society for Microbiology News 51: 460–467.
Eisenstein, B.J. 1987. Pathogenic mechanisms of Legionella pneumophila and Escherichia coli. American Society for Microbiology News 53: 621–624.
Favero, M.S., Carson, L.A., Bond, WW., and Peterson, N.J. 1971. Pseudomonas aeruginosa: growth in distilled water from hospitals. Science 173: 836–838.
Feeley, J.C., Gorman, G.W., Weaver. R.E., Mackel, D.C., and Smith, H.W. 1978. Primary isolation media for Legionnaires’ disease bacterium. Journal of Clinical Microbiology 8: 320–325.
Feeley, J.C., Gibson, R.J., and Gorman, G.W 1979. Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila Journal of Clinical Microbiology 10: 437–441.
Fields, B.S., Shotts, E.B., Feeley, J.C., Gorman, G.W., and Martin, W.J. 1984. Proliferation of Legionella pneumophila as an intracellular parasite of the ciliated protozoan Tetrahymena pyriformis. Applied and Environmental Microbiology 47: 467–471.
Fields, B.S., Barbaree, J.M., Shotts, E.B., Feeley, J.C., Morrill W.E., Sanden, G.N., and Dykstra, M.J. 1986. Comparison of guinea pig and protozoan models for determining virulence of Legionella species. Infection and Immunity 53: 553–559.
Fields, B.S., Sanden, G.N., Barbaree, J.M., Morrill, W.E., Wadowsky, R.M., White, E.H., and Feeley, J.C. 1989. Intracellular multiplication of Legionella pneumophila in amoebae isolated from hospital hot water tanks. Current Microbiology 18: 131–137.
Fisher-Hoch, S.P., Tobin, J.O’H., Nelson, A.M., Smith, M.G., Talbot, J.M., Bartlett, C.L.R., Gillet, M.B., Pritchard, J.E., Swann, R.A., and Thomas, J.A. 1981. Investigation and control of an outbreak of Legionnaires’ Disease in a district general hospital. Lancet i:932–936.
Fleming, D.W., and Reingold, A.L. 1986. Legionella, pp. 352–358 in Braude, A.I., Davis, C.E. and Fierer, J. (editors). Infectious Diseases and Medical Microbiology, WB. Saunders Company, Philadelphia.
Fliermans, C.B., Cherry, W.B., Orrison, L.H., and Thacker, L. 1979. Isolation of Legionella pneumophila from nonepidemic related aquatic habitats. Applied and Environmental Microbiology 37: 1239–1242.
Fliermans, C.B., Cherry, W.B., Orrison, L.H., Smith, S.J., Tison, D.L., and Pope, D.H. 1981. Ecological distribution of Legionella pneumophila. Applied and Environmental Microbiology 41: 9–16.
Fliermans, C.B., Bettinger, G.E., and Fynsk, A.W. 1982. Treatment of cooling systems containing high levels of Legionella pneumophila. Water Research 16: 903–909.
Fliermans, C.B. 1984. Philosophical ecology: Legionella in historical perspective, pp. 285–289 in Thornsberry, C., Balows, A., Feeley, J.C. and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium, American Society for Microbiology, Washington, DC.
Foy, H.M., Hayes, P.S., Cooney, MX, Broome, C.V., Allan, I., and Tobe, R. 1979. Legionnaires’ disease in a prepaid medical-care group in Seattle, 1963–75. Lancet i: 767–770.
Fraser, D.W., Tsai, T.F., Orenstein, W., Parkin, W.E., Beecham, H.J., Sharrar, R.G., Harris, J., Mallison, G.F., Martin, S.M., McDade, J.E., Shepard, C.C., Brachman, P.S., and The Field Investigation Team. 1977. Legionnaire’s disease: A description of an epidemic of pneumonia. New England Journal of Medicine 297: 1189–1197.
Gilpin, R.W. 1984. Laboratory and field applications of U.V. light disinfection on six species of Legionella and other bacteria in water, pp. 337–339 in Thornsberry, C., Balows, A., Feeley, J.C., and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium. American Society for Microbiology. Washington, DC.
Glick, T.H., Gregg, M.B., Berman, B., Mallison, G.W., Rhodes, WW, and Kassanoff, 1978. Pontiac fever: An epidemic of unknown etiology in a Health Department. I. clinical and epidemiological aspects. American Journal of Epidemiology 107: 149–160.
Gorman, G.W, Feeley, J.C., Steigerwalt, A., Edelstein, P.H., Moss, C.W., and Brenner, D.J. 1985. Legionella anisa: A new species of Legionella isolated from potable waters and a cooling tower. Applied and Environmental Microbiology 49: 305–309.
Helms, C.M., Massonari, R.M., Zeitler, R., Streed, S., Gilchrist, M.J.R., Hall N., Hausier, W.J., Sywassin, J., Johnson, W, Wintermeyer, L., and Hieholzer, WV. 1983. Legionnaires’ disease associated with a hospital water system: a cluster of 24 nosocomial cases. Annals of Internal Medicine 99: 172–178.
Helms, C.M., Massanari, M. Wenzel, R.P., Pfaller, M.A., Moyer, N.P., and Hall, M.T. 1988. Legionnaires’ disease associated with a hospital water system: A five-year progress report on continuous hyperchlorination. Journal of the American Medical Association 259: 2423–2427.
Holden, E.P., Winkler, H.H., Wood, D.O., and Leinbach, E.D. 1984. Intracellular growth of Legionella pneumophila within Acanthamoeba castellanii Neff. Infection and Immunity 45: 18–24.
Hsu, S.C., Martin, R., and Wentworth, B.B. 1984. Isolation of Legionella species from drinking water. Applied and Environmental Microbiology 48: 830–832.
Joly, J.R. and Winn, WC. 1984. Correlation of sub-types of Legionella pneumophila defined by monoclonal antibodies with epidemiological classification of cases and environmental sources. Journal of Infectious Diseases 150: 667–671.
Joly, J.R., Dewaily, E., Bernard, L., Ramsey, D, and Brisson, J. 1985. Legionella and domestic water heaters in Quebec City area. Canadian Medical Association Journal 132: 160.
Kemmer, F.N. and McCallion J. (editors). 1979. The Nalco Water Handbook, McGraw-Hill Book Co., New York.
King, C.H., Shotts, E.B., Wooley, R.E., and Porter, K.G. 1988. Survival of coliforms and bacterial pathogens within protozoa during chlorination. Applied and Environmental Microbiology 54: 3023–3033.
Knudson, G.B. 1985. Photoreactivation of U.V. irradiated Legionella pneumophila and other Legionella species. Applied and Environmental Microbiology 49: 975–980.
Kuchta, J.M., States, S.J., McNamara, A.M., Wadowsky, R.M., and Yee, R.B. 1983. Susceptibility of Legionella pneumophila to chlorine in tap water. Applied and Environmental Microbiology 46: 1134–1139.
Kuuchta, J.M., States, S.J., McGaughlin, J.E., Overmeyer, J.H., Wadowsky, R.M., McNamara, A.M., Wolford, R.S., and Yee, R.B. 1985. Enhanced chlorine resistance of tap water adapted Legionella pneumophila as compared with agar-medium passaged strains. Applied and Environmental Microbiology 50: 21–26.
Kurtz, J.B., Bartlett, C.J.R., Newton, V.A., White, R.A., and Jones, N.L. 1982. Legionella pneumophila in cooling water systems: Report on a survey of cooling towers in London and a pilot trial of selected biocides. Journal of Hygiene 88: 369–381.
Kyle, D.E. and Noblett, G.P. 1985. Vertical distribution of potentially pathogenic free-living amoebae in freshwater lakes. Journal of Protozoology 32: 99–105.
Lee, T.C., Stout, J.E., and Yu, V.L. 1988. Factors predisposing to Legionella pneumophila colonization in residential water systems. Archives of Environmental Health 43: 59–62.
McDade, J.E., Shepard, C.C., Fraser, D.W., Tsai, T.F., Redus, M.A., Dowdle, W.R., and The Laboratory Investigation Team. 1977. Legionnaire’s disease: Isolation of a bacterium and demonstration of its role in other respiratory disease. New England Journal Of Medicine 297: 1197–1205.
McDade, J.E., Brenner, D.J., and Bozeman, F.M. 1979. Legionnaires disease bacterium isolated in 1947. Annals of Internal Medicine 90: 659–661.
Mead, P.B., Lawson, J.M., and Patterson, J.W. 1988. Chlorination of water supplies to control Legionella may corrode the pipes. Journal of the American Medical Association 260: 2216.
Moss, C.W., Weaver, R.E., Dees, S.B., and Cherry, W. 1977. Cellular fatty acid composition of isolates from Legionnaires disease. Journal of Clinical Microbiology 6: 140–143.
Muder, R.R., Yu, V.L, McClure, J.K., Kroboth, F.J., Kominos, S.D., and Lumish, R.M. 1983. Nosocomial legionnaires’ disease uncovered in a prospective pneumonia study. Journal of the American Medical Association 249: 3184–3188.
Muraca, P., Stout, J.E., and Yu, V.L 1987. Comparative assessment of chlorine, heat, ozone and U.V. light for killing Legionella pneumophila within a model plumbing system. Applied and Environmental Microbiology 53: 447–453.
Ormsbee, R.A., Peacock, M.G., Bickel, W.D., and Fiset, P. 1981. A comparison of some biologic characteristics of isolates of the Legionnaire’s disease bacterium. Annals of Clinical Laboratory Science 11: 53–62.
Pasculle, A.W., Feeley, J.C. Gibson, R.J., Cordes, L.G., Myerowitz, R.L., Patton, C.M., Gorman, G.W, Carmack, C.L., Ezzell, J.W., and Dowling, J.N. 1980. Pittsburgh pneumonia agent: Direct isolation from human lung tissue. Journal of Infectious Disease 141: 727–732.
Politi, B.D., Fraser, D.W., Mallison, G.F., Mohatt, J.V., Morris, G.K., Patton, C.M., Feeley, J.C., Telle, R.D., and Bennett, J.V. 1979. A major focus of Legionnaire’s disease in Bloomington, Indiana. Annals of Internal Medicine 90: 587–591.
Pope, D.H., Soracco, R.J., Gill, H.K., and Fliermans, C.B. 1982. Growth of Legionella pneumophila in two-membered cultures with green algae and cyanobacteria. Current Microbiology 7: 319–322.
Public Works Canada. 1986a. Legionella Control in Hospitals—Standards and Guidelines (Supplement), MD15161. Engineering Technology Directorate, Canada.
Public Works Canada. 1986b. Legionella Control in Hospitals—Standards and Guidelines, MD15161S. Engineering Technologv Directorate, Canada.
Reeves, M.W, Pine, L., Hutner, S.H., George, J.R., and Harrell, W.K. 1981. Metal requirements of Legionella pneumophila. Journal of Clinical Microbiology 13: 688–695.
Ristroph, J.D., Hedlund, K.W., and Gowda, S. 1981. Chemically defined medium for Legionella pneumophila growth. Journal of Clinical Microbiology 13: 115–119.
Roberts, K.P., August, C.M., and Nelson, J.D. 1987. Relative sensitivities of environmental legionellae to selective isolation procedures. Applied and Environmental Microbiology 12: 2704–2707.
Rowbotham, T.J. 1980. Preliminary report on the pathogenicity of Legionella pneumophila for freshwater and soil amoebae. Journal of Clinical Pathology 33: 1179–1183.
Rowbotham, T.J. 1983. Isolation of Legionella pneumophila from clinical specimens via amoebae and the interaction of those and other isolates with amoebae. Journal of clinical Pathology 36: 978–986.
Rowbotham, T.J. 1986. Current views on the relationship between amoeba, Legionella, and Man. Israel Journal of Medical Sciences 22: 679–689.
Schofield, G.M. and Locci, R. 1985. Colonization of components of a model hot water system by Legionella pneumophila. Journal of Applied Bacteriology 58: 151–162.
Shands, K.N., Ho, J.L., Meyer, R.D., Gorman, G.W., Edelstein, P.H., Mallison, G.F., Finegold, S.M., and Fraser, D.W. 1985. Pbtable water as a source of Legionnaires’ disease. Journal of the American Medical Association 253: 1412–1416.
Skinner, A.R., Anand, C.M., Malic, A., and Kurtz, J.B. 1983. Acanthamoebae and environmental spread of Legionella pneumophila. Lancet ii:289–290.
States, S.J., Conley, L.F., Ceraso, M. Stephenson, T.E., Wolford, R.S., Wadowsky, R.M., McNamara, A.M., and Yee, R.B. 1985. Effects of metals on Legionella pneumophila growth in drinking water plumbing systems. Applied and Environmental Microbiology 50: 1149–1154.
States, S.J., Conley, L.F., Kuchta, J.M., Oleck, B.M., Lipovich, M.J., Wolford, R.S., Wadowsky, R.M., McNamara, A.M., Sykora, J.L., Keleti, G., and Yee, R.B. 1987a. Survival and multiplication of Legionella pneumophila in municipal drinking water systems. Applied and Environmental Microbiology 53: 979–986.
States, S.J., Conley, L.F., Towner, S.G., Wolford, R.S., Stephenson, T.E., McNamara, A.M., Wadowsky, R.M., and Yee, R.B. 1987b. An alkaline approach to treating cooling towers for control of Legionella pneumophila. Applied and Environmental Microbiology 53: 1775–1779.
States, S.J., Conley, L.F., Knezivich, C.R., Keleti, G., Sykora, J.L., Wadowsky, R.M., and Yee, R.B. 1988. Free-living amoebae in public water supplies: Implications for Legionella, Giardia, and Cryptosporidia, in Proceedings of the American Water Works Association Water Quality Technology Conference, St. Louis, Missouri.
States, S.J., Conley, L.F., Kuchta, J.M., Wolford, R.S., Wadowsky, R.M. and Yee, R.B. 1989. Chlorine, pH and control of Legionella in hospital plumbing systems. Journal of the American Medical Association 261: 1882–1883.
Stout, J., Yu, V.L., Vickers, R.M., Zuravleff, J., Best, M., Brown, A., Yee, R.B., and Wadowsky, R. 1982. Ubiquitousness of Legionella pneumophila in the water supply of a hospital with endemic Legionnaires’ Disease. New England Journal of Medicine 306: 466–468
Stout, J.E., Yu, V.L., and Best, M.G. 1985. Ecology of Legionella pneumophila within water distribution systems. Applied and Environmental Microbiology 49: 221–228.
Stout, J.E., Yu, V.L., and Muraca, P. 1987. Legionnaires’ disease acquired within the homes of two patients. Journal of the American Medical Society 257: 1215–1217.
Sykora, J.L., Keleti, G., and Martinez, J. 1985. Occurrence and pathogenicity of Naegleria fowleri in artificially heated waters. Applied and Environmental Microbiology 45: 974–979.
Tesh, M.J. and Miller, R.D. 1981. Amino acid requirements for Legionella pneumophila growth. Journal of Clinical Microbiology 13: 865–869.
Tesh, M.J. and Miller, R.D. 1982. Growth of Legionella pneumophila in defined media: Requirement for magnesium and potassium. Canadian Journal of Microbiology 28: 1055–1058.
Tison, D.L., Pope, D.H. Cherry, W.B., and Fliermans, C.B. 1980. Growth of Legionella pneumophila in association with blue-green algae (cyanobacteria). Applied and Environmental Microbiology 39: 456–459.
Tison, D.L and Seidler, R.J. 1983. Legionella incidence and density in potable drinking water supplies. Applied and Environmental Microbiology 45: 337–339.
Tobin, J.O’H., Beare, J., Dunnill, M.S., Fisher-Hoch, S., French, M. Mitchell, R.G., Morris, P.J., and Muers, M.F. 1980. Legionnaires’ disease in a transplant unit: Isolation of the causative agent from shower baths. Lancet ii:118–121.
Tobin, J.O’H., Swann, R.A., and Bartlett, C.L.R. 1981a. Isolation of Legionella pneumophila from water systems: Methods and preliminary results. British Medical Journal 282: 515–517.
Tobin, J.O’H., Bartlett, C.L.R., and Waitkins, S.A. 1981b. Legionnaires’ disease: Further evidence to implicate water storage and distribution systems as sources. British Medical Journal 282: 573.
Tobin, J.O’H., Watkins, I.D., Woodhead, S., and Mitchell, R.G. 1986. Epidemiological studies using monoclonal antibodies to Legionella pneumophila. Israel Journal of Medical Sciences 22: 711–714.
Tyndall, R.L. and Domingue, E.L. 1982. Cocultivation of Legionella pneumophila and free-living amoebae. Applied and Environmental Microbiology 44: 954–959.
U.S. Environmental Protection Agency. 1985. National primary drinking water regulations; volatile synthetic organic chemicals; final rule and proposed rule. Federal Register 50: 46880–47025.
U.S. Environmental Protection Agency. 1987. Control of Legionella in plumbing systems. In Health Advisories for Legionella and Seven Inorganics, Office of Drinking Water, Washington, DC.
Vickers, R.M., Brown, A., and Garrity, C.L.R. 1981. Dye-containing buffered charcoal-yeast extract medium for differentiation of the family Legionellaceae. Journal of Clinical Microbiology 13: 380–382.
Wadowsky, R.M. and Yee, R.B. 1981. Glycine-containing selective medium for isolation of Legionellaceae from environmental specimens. Applied and Environmental Microbiology 42: 768–772.
Wadowsky, R.M., Yee, R.B., Mezmar, L., Wing, E.J., and Dowling, J.N. 1982. Hot water systems as sources of Legionella pneumophila in hospital and nonhospital plumbing fixtures. Applied and Environmental Microbiology 43: 1104–1110.
Wadowsky, R.M. and Yee, R.B. 1983. Satellite growth of Legionella pneumophila with an environmental isolate of Flavobacterium breve. Applied and Environmental Microbiology 46: 1447–1449.
Wadowsky, R.M. and Yee, R.B. 1985a. Effect of non-Legionellaceae bacteria on the multiplication of Legionella pneumophila in potable water. Applied and Environmental Microbiology 49: 1206–1210.
Wadowsky, R.M., Wolford, R., McNamara, A.M., and Yee, R.B. 1985b. Effect of temperature, pH, and oxygen level on the multiplication of naturally occurring Legionella pneumophila in potable water. Applied and Environmental Microbiology 49: 1197–1205.
Wadowsky, R.M., Butler, L.J., Cook, M.K., Verma, S.M., Paul, M.A., Fields, B.S., Keleti, G., Sykora, J.L., and Yee, R.B. 1988. Growth-supporting activity of Legionella pneumophila in tap water cultures and implication of harmannellid amoebae as growth factors. Applied and Environmental Microbiology 54: 2677–2682.
Watkins, I.D., Tobin, J.O’H., Dennis, P.J., Brown, W., Newnham, R., and Kurtz, J.B. 1985. Legionella pneumophila serogroup 1 subgrouping by monoclonal antibodies. Journal of Hygiene 95: 211–216.
Witherall, L.E., Orciari, L.A., Spitalny, K.C., Pelletier, R.A., Stone, K.M., and Vogt, R.L. 1984. Disinfection of Legionella pneumophila—contaminated whirlpool spas. pp. 339–340 in Thomsberry, C., Balows, A., Feeley, J.C., and Jakubowski, W. (editors), Legionella: Proceedings of the Second International Symposium, American Society for Microbiology, Washington, D.C.
Witherell, L.E., Duncan,R.W, Stone, K.M., Stralton, L.J., Orciari, L., Kappel, S., and Jillson, D.A. 1988. Investigation of Legionella pneumophila ion drinking water. American Water Works Association Journal 80: 87–93.
Yee, R.B. and Wadowsky, R.M. 1982. Multiplication of Legionella pneumophila in unsterilized tap water. Applied and Environmental Microbiology 43: 1330–1334.
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States, S.J., Wadowsky, R.M., Kuchta, J.M., Wolford, R.S., Conley, L.F., Yee, R.B. (1990). Legionella in Drinking Water. In: McFeters, G.A. (eds) Drinking Water Microbiology. Brock/Springer Series in Contemporary Bioscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4464-6_16
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DOI: https://doi.org/10.1007/978-1-4612-4464-6_16
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