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Tissue Engineering Cartilage and Bone

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Synthetic Biodegradable Polymer Scaffolds

Abstract

Tissue engineering is an emerging multidisciplinary field in which the material properties of synthetic compounds are manipulated to enable delivery of an aggregate of dissociated cells into a host in a manner that will result in the formation of new functional tissue. A high density of viable, dissociated functional cells can be seeded onto synthetic, biocompatible, biodegradable polymers of an appropriate chemical composition and physical configuration, which act as scaffolds. They allow diffusion of nutrients to the cells, as well as cell-to cell contact and can then be transplanted into animals. The purpose of this new field of research is to repair, replace, maintain, or enhance the function of a particular tissue or organ. Cells can be isolated from an individual, expanded in vitro and/or modified by gene therapy to replace a defective gene, and reimplanted.

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Author information

Authors and Affiliations

  1. Laboratory for Tissue Engineering, Department of Anesthesiology, University of Massachusetts Medical Center, 55 Lake Avenue North, S2-751, 01655-0300, Worcester, MA, USA

    Yilin Cao MD, PhD, Clemente Ibarra MD & Charles A. Vacanti MD

Authors
  1. Yilin Cao MD, PhD
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  2. Clemente Ibarra MD
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  3. Charles A. Vacanti MD
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Editor information

Editors and Affiliations

  1. Laboratory for Tissue Engineering, Division of Urology and Department of Surgery, Children’s Hospital and Harvard Medical School, 300 Longwood Avenue, 02115, Boston, MA, USA

    Anthony Atala MD (Director) (Director)

  2. Departments of Biologic and Materials Sciences and Chemical Engineering, The University of Michigan, 48109, Ann Arbor, MI, USA

    David J. Mooney PhD

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© 1997 Birkhäuser Boston

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Cao, Y., Ibarra, C., Vacanti, C.A. (1997). Tissue Engineering Cartilage and Bone. In: Atala, A., Mooney, D.J. (eds) Synthetic Biodegradable Polymer Scaffolds. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4154-6_11

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  • DOI: https://doi.org/10.1007/978-1-4612-4154-6_11

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8677-6

  • Online ISBN: 978-1-4612-4154-6

  • eBook Packages: Springer Book Archive

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