Abstract
This chapter presents a summary of the efficacy data that form the basis for the clinical use of ivermectin in cattle, sheep, goats, and swine. At least 2 adequate and well-controlled trials investigated each ivermectin formulation’s effect on each parasite species. Most of the trials were conducted by MSDRL investigators, though investigators at other laboratories also contributed. The efficacy percentages presented here are those upon which the regulatory approvals were based. Animal health applications of ivermectin have been reviewed (Campbell et al. 1983; Campbell and Benz 1984; Benz 1985; Campbell 1985; Bennett 1986; Barragry 1987). Clinical usages have also been summarized concerning cattle (Leaning, Roncalli, and Brokken 1983), sheep (Hotson 1983), and swine (Brokken et al. 1983). Recent reports that expand the basis of the label claims are included.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Alva-Valdes R, Wallace DH, Holste JE, Egerton JR, Cox JL, Wooden JW, Barrick RA (1986) Efficacy of ivermectin in a topical formulation against induced gastrointestinal and pulmonary nematode infections, and naturally acquired grubs and lice in cattle. Am. J. Vet. Res. 47:2389–2392.
Armour J, Bairden K, Batty AF, Davison CC, Ross D (1985) Persistent anthelmintic activity of ivermectin in cattle. Vet. Rec. 116:151–153.
Armour J, Bairden K, Ryan WG (1988) Immunity of ivermectin treated cattle to challenge from helminth parasites in the following season. Vet. Rec. 122:223–225.
Baggott DG, Batty AF, Ross DB (1986) The control of mature nematode infections in cattle by sustained delivery of ivermectin. Proceedings of the 14th World Congress on Diseases of Cattle, Vol. 1, Dublin, Ireland, pp 160–165.
Barragry TB (1987) A review of the pharmacology and clinical uses of ivermectin. Can. Vet. J. 28:512–517.
Barth D (1983) Persistent anthelmintic effect of ivermectin in cattle. Vet. Rec. 113:300.
Barth D, Batty AF, Robin B, Preston JM (1986) Efficacy of a topical formulation of ivermectin against cattle ectoparasites. Proceedings 14th World Congress of Diseases of Cattle, Vol 1, Dublin, Ireland, pp 157–159.
Barth D, Preston JM (1985) Efficacy against somatic Strongyloides ransomi larvae. Vet. Rec. 116:366–367.
Bennett DG (1986) Clinical pharmacology of ivermectin. J. Am. Vet. Med. Assoc. 189:100–104.
Benz GW (1985) Animal health applications of ivermectin. Southwest. Entomol. (Suppl.) 7:43–50.
Brokken ES, Barth D, Foster AG, Pulliam JD, Wallace DH (1983) Ivermectin, a new broad-spectrum antiparasitic agent for swine. In Proceedings of the MSD AGVET Symposium “Recent Developments in the Control of Animal Parasites”, in association with the XXII World Veterinary Congress, Perth, Australia, pp 239–258.
Campbell WC (1985) Ivermectin: An update. Parasitol. Today 1:10–16.
Campbell WC, Benz GW (1984) Ivermectin: A review of efficacy and safety. J. Vet. Pharm. Therap. 7:1–16.
Campbell WC, Fisher MH, Stapley EO, Albers-Schonberg G, Jacobs TA (1983) Ivermectin: A potent new antiparasitic agent. Science 221:823–828.
Carmichael IH, Soll MD, Scherer H (1985) The use of ivermectin in the control of bovine thelaziosis. 11th Conference World Association for the Advancement of Veterinary Parasitology, Rio de Janeiro, Abstract 106.
Carmichael IH, Visser R, Schneider D, Soll MD (1987) Haemonchus contortus resistance to ivermectin (Letter to Editor). J. S. Afr. Vet. Assoc. 58:93.
Courtney CH, Ingalls WL, Stitzlein SL (1983) Ivermectin for the control of swine scabies: Relative values of prefarrowing treatment of sows and weaning treatment of pigs. Am. J. Vet. Res. 44:1220–1223.
Cramer LG, Carvalho LAF, Bridl AA, Amaral NK, Barrick RA (1985) Topically applied ivermectin: Efficacy against Boophilus microplus in cattle. 11th Conference World Association for Advancement of Veterinary Parasitology, Rio de Janeiro, Abstract 126.
Dakkak A, Robin B, Kachani M (1986) Efficacy of ivermectin in the ewe. Rev. Med. Vet. (Toulouse) 137:781–787 (in French).
Echevarria FAM, Trindade GNP (1989) Anthelmintic resistance by Haemonchus contortus to ivermectin in Brazil: A preliminary report. Vet. Rec. 124:147–148.
Eckenhoff B, Cortese R, Wright JC, Wilkinson PK, Zingerman JR, Pope DG (1987) Osmotically-driven ruminal delivery system for long term rate controlled delivery of ivermectin. Pharm. Res. (Suppl.) 4:46.
Egerton JR, Suhayda D, Eary CH (1986) Prophylaxis of nematode infections in cattle with an indwelling rumino-reticular ivermectin sustained release bolus. Vet. Parasit. 22:67–75.
Egerton JR, Suhayda D, Eary CH (1988) Laboratory selection of Haemonchus contortus for resistance to ivermectin. J. Parasit. 74:614–617.
Giordano DJ, Tritschler JP, Coles GC (1987) Selection of ivermectin resistant Trichostrongylus colubriformis in lambs. Proceedings 12th Conference World Association for Advancement of Veterinary Parasitology, Montreal, Abstract No. 8A-5.
Guillot FS, Wright FC, Oehler D (1986) Concentration of ivermectin in bovine serum and its effect on the fecundity of psoroptic mange mites. Am. J. Vet. Res. 47:525–527.
Hogg A (1984) Eradication of sarcoptic mange in swine with ivermectin. Proceedings 8th International Pig Veterinary Society Congress, Ghent, Belgium, p 206.
Hotson IK (1983) The development of ivermectin as an antiparasitic agent in sheep. In Proceedings of the MSD AGVET Symposium “Recent Developments in the Control of Animal Parasites”, in association with the XXII World Veterinary Congress, Perth, Australia, pp 42–55.
Hotson IK, Bliss WJ, Cox JL, Roncalli RA, Sutherland IH (1985) Efficacy of topically administered ivermectin against cattle parasites. 11th Conference World Association for Advancement of Veterinary Parasitology, Rio de Janeirio, Abstract 112.
Jacobs DE, Fox MT, Ryan WG (1987) Early season parasitic gastroenteritis in calves and its prevention with ivermectin. Vet. Rec. 120:29–31.
Kirkwood AC (1985) Some observations on the biology and control of the sheep scab mite Psoroptes ovis (Herring) in Britain. Vet. Parasitol. 18:269–279.
Leaning WHD, Roncalli RA, Brokken ES (1983) The efficacy and safety evaluation of ivermectin: A new injectable antiparasitic agent for cattle. In Proceedings of the MSD AGVET Symposium “Recent Developments in the Control of Animal Parasites”, in association with the XXII World Veterinary Congress, Perth, Australia, pp 25–41.
Plue RE, Brokken ES, Ericsson GF, Foster AG, Wallace DH (1986) A review of ivermectin efficacy against adult and immature Stephanurus dentatus. Proceedings 9th International Pig Veterinary Society Congress, p 375.
Pope DG, Wilkinson PK, Egerton JR, Conroy J (1985) Oral controlled-release delivery of ivermectin in cattle via an osmotic pump. J. Pharm. Sci. 74:1108–1110.
Roncalli RA (1984a) Efficacy of ivermectin against Oestrus ovis in sheep. Vet. Med. Small Ani. Clinic. 79:1095–1097.
Roncalli RA (1984b) The biology and the control of Dermatobia hominis, the tropical warble-fly of Latin America. Prevent. Vet. Med. 2:569–578.
Roncalli RA, Hotson IK, Benitez-Usher C, Bridi AA (1984c) Efficacy of ivermectin against Boophilus spp. in cattle. Proceedings of 29th Annual Meeting of American Association of Veterinary Parasitologists, New Orleans, Abstract 12.
Roncalli RA, Sutherland IH (1986) The use of ivermectin injectable against Psoroptes ovis (Acarina: Psoroptidae) in sheep. Proceedings 31st Annual Meeting American Association of Veterinary Parasitologists, No. 10.
Ryan WG, Armour J, Bairden K, Fox MT, Jacobs DE (1986) Early season use of ivermectin to control parasitic gastroenteritis and bronchitis in calves. Proceedings of the 14th World Congress of Diseases of Cattle, Dublin, Ireland, Vol. 1, pp 185–190.
Soll MD, Carmichael IH, Gross SJ (1987) Control of induced infestations of adult Amblyomma hebraeum with sustained release ivermectin. Onderstepoort J. Vet. Res. 54:17–20.
Soll MD, Carmichael IH, Harvey RG (1988) Prophylactic efficacy of sustained-release ivermectin against induced nematode infestations in cattle. J. S. Afr. Vet. Assoc. 59:9–11.
Soll MD, Swan GE, Schroder J, Bezuidenhout JD (1984) Efficacy of ivermectin against the sand tampan (Ornithodoros savignyi). Vet. Rec. 114:70.
Strickland RK, Gerrish RR (1987) Infestivity of Psoroptes ovis on ivermectin-treated cattle. Am. J. Vet. Res. 48:342–344.
Swan GE, Gross SJ (1985) Efficacy of ivermectin against induced gastrointestinal nematode infections in goats. Vet. Rec. 117:147–149.
Swan GE, Soll MD, Carmichael IH, Schroder J (1983) Efficacy of ivermectin against Parafilaria bovicola. Vet. Rec. 113:260.
Taylor SM, Mallon TR, Kenny J (1985) Comparison of early season suppressive anthelmintic prophylactic methods for parasitic gastroenteritis and bronchitis in calves. Vet. Rec. 117:521–524.
van Wyk JA, Malan FS (1988) Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa. Vet. Rec. 123:226–228.
van Wyk JA, Malan FS, Gerber HM, Alva RMR (1987) Two field strains of Haemonchus contortus resistant to rafoxanide. Onderstepoort J. Vet. Res. 54:143–146.
Wilkinson PK, Baggott DG, Zingerman JR, Pope DG, Eckenhoff B (1987) In-vivo performance of a new osmotically driven, long term rate controlled delivery system for ivermectin in cattle. Pharm. Res. (Supplement) 4:46.
Wright FC, Guillot FS (1984) Effect of ivermectin in heifers on mortality and egg production of Psoroptes ovis. Am. J. Vet. Res. 45:2132–2134.
Yazwinski TA, Wood N, Holtzen HM, Presson BL, Kilgore RL (1986) Measuring the anthelmintic efficacy of a new formulation of ivermectin. Vet. Med. Small Ani. Clinic. 81:1175–1177.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Benz, G.W., Roncalli, R.A., Gross, S.J. (1989). Use of Ivermectin in Cattle, Sheep, Goats, and Swine. In: Campbell, W.C. (eds) Ivermectin and Abamectin. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3626-9_15
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3626-9_15
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8184-9
Online ISBN: 978-1-4612-3626-9
eBook Packages: Springer Book Archive