Abstract
In recent years recombinant human growth hormone (rhGH) has been increasingly used to treat short stature in children with chronic renal disease. Its efficacy to accelerate short-term growth has been clearly demonstrated in a large number of patients with chronic renal failure (1-4) and following renal transplantation (5, 6). However, it remains unproven that rhGH will improve final adult height in this group of patients. Few side effects have been reported, though fasting serum insulin levels may rise (6), and the possibility of accelerated deterioration in renal function is a concern, particularly in the transplant population (5). Somewhat surprisingly, despite the importance of malnutrition and renal osteodystrophy in the genesis of growth retardation associated with chronic renal disease, little information has been provided concerning the effects of rhGH on dietary intake and bone metabolism in these patients.
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Geary, D.F., Welch, K. (1995). Growth Hormone in Children with Chronic Renal Disease: Some Metabolic Considerations. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_7
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DOI: https://doi.org/10.1007/978-1-4612-0807-5_7
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